Imaging of Viral Genomic RNA Replication with Nanoprobes.

Autor: Hu PP; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, College of Pharmacy, Chongqing Medical University, Chongqing, China.; Key Laboratory of Biomedical Analytics, Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, China., Zheng LL; Biomedical Analysis Center, Army Medical University, Chongqing, China., Zhan L; Key Laboratory of Biomedical Analytics, Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, China., Huang CZ; Key Laboratory of Biomedical Analytics, Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, China.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2875, pp. 145-153.

Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability.

Autor: Masnovo C; Department of Biology, Tufts University, Medford, MA, 02155, USA., Paleiov Z; Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er Sheva, 8410501, Israel., Dovrat D; Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er Sheva, 8410501, Israel., Baxter LK; Department of Biology, Tufts University, Medford, MA, 02155, USA., Movafaghi S; Department of Biology, Tufts University, Medford, MA, 02155, USA., Aharoni A; Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er Sheva, 8410501, Israel., Mirkin SM; Department of Biology, Tufts University, Medford, MA, 02155, USA. sergei.mirkin@tufts.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Dec 03; Vol. 15 (1), pp. 10532. Date of Electronic Publication: 2024 Dec 03.

Enhancing transcription-replication conflict targets ecDNA-positive cancers.

Autor: Tang J; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Weiser NE; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Wang G; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Chowdhry S; Boundless Bio, San Diego, CA, USA., Curtis EJ; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Medical Scientist Training Program, University of California, San Diego, La Jolla, CA, USA., Zhao Y; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA., Wong IT; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Marinov GK; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Li R; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Hanoian P; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Tse E; Boundless Bio, San Diego, CA, USA., Mojica SG; Boundless Bio, San Diego, CA, USA., Hansen R; Boundless Bio, San Diego, CA, USA., Plum J; Boundless Bio, San Diego, CA, USA., Steffy A; Boundless Bio, San Diego, CA, USA., Milutinovic S; Boundless Bio, San Diego, CA, USA., Meyer ST; Boundless Bio, San Diego, CA, USA., Luebeck J; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA., Wang Y; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Zhang S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Altemose N; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Curtis C; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Greenleaf WJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Bafna V; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA., Benkovic SJ; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Pinkerton AB; Boundless Bio, San Diego, CA, USA., Kasibhatla S; Boundless Bio, San Diego, CA, USA., Hassig CA; Boundless Bio, San Diego, CA, USA. chassig@boundlessbio.com., Mischel PS; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. pmischel@stanford.edu.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA. pmischel@stanford.edu., Chang HY; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. howchang@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. howchang@stanford.edu.; Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA. howchang@stanford.edu.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. howchang@stanford.edu.

Publikováno v: Nature [Nature] 2024 Nov; Vol. 635 (8037), pp. 210-218. Date of Electronic Publication: 2024 Nov 06.

Molecular mechanism of parental H3/H4 recycling at a replication fork.

Autor: Nagae F; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan., Murayama Y; Department of Chromosome Science, National Institute of Genetics, Shizuoka, Japan.; Department of Genetics, Graduate University for Advanced Studies (SOKENDAI), Shizuoka, Japan., Terakawa T; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan. terakawa@biophys.kyoto-u.ac.jp.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 02; Vol. 15 (1), pp. 9485. Date of Electronic Publication: 2024 Nov 02.

Expanding the genetic and phenotypic landscape of replication factor C complex-related disorders: RFC4 deficiency is linked to a multisystemic disorder.

Autor: Morimoto M; National Institutes of Health Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Ryu E; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea., Steger BJ; National Institutes of Health Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Dixit A; Nottingham University Hospital, Nottingham, UK., Saito Y; Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., Yoo J; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea., van der Ven AT; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hauser N; Inova Translational Medicine Institute, Inova Health System, Falls Church, VA, USA., Steinbach PJ; Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Oura K; Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine Iwate Medical University, Morioka, Japan., Huang AY; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Kortüm F; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ninomiya S; Department of Clinical Genetics, Kurashiki Central Hospital, Okayama, Japan., Rosenthal EA; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA., Robinson HK; Exeter Genomics Laboratory, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Guegan K; Exeter Genomics Laboratory, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Denecke J; Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Subramony SH; Department of Neurology, University of Florida College of Medicine, Gainesville, FL, USA., Diamonstein CJ; Inova Translational Medicine Institute, Inova Health System, Falls Church, VA, USA., Ping J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Fenner M; Nottingham University Hospital, Nottingham, UK., Balton EV; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA., Strohbehn S; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA., Allworth A; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA., Bamshad MJ; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA., Gandhi M; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA., Dipple KM; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA., Blue EE; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA; University of Washington School of Public Health, Institute for Public Health Genetics, Seattle, WA, USA., Jarvik GP; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA; Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Lau CC; National Institutes of Health Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Holm IA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Weisz-Hubshman M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Solomon BD; Inova Translational Medicine Institute, Inova Health System, Falls Church, VA, USA., Nelson SF; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Nishino I; Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., Adams DR; National Institutes of Health Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA; Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Kang S; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea., Gahl WA; National Institutes of Health Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA; Human Biochemical Genetics Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Toro C; National Institutes of Health Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Myung K; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea., Malicdan MCV; National Institutes of Health Undiagnosed Diseases Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA; Human Biochemical Genetics Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: maychristine.malicdan@nih.gov.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2024 Sep 05; Vol. 111 (9), pp. 1970-1993. Date of Electronic Publication: 2024 Aug 05.