Výsledky vyhledávání - "AND NIKOLAUS SEILER"

Publikováno v: Critical Reviews in Clinical Laboratory Sciences. 44:365-411

Owing to their high turnover, the intestinal mucosal cells have a particularly high requirement for polyamines. Therefore, they are an excellent charcol for the study of polyamine function in rapid physiological growth and differentiation. After a cu

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https://doi.org/10.1080/10408360701250016

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Thirty Years of Polyamine-Related Approaches to Cancer Therapy. Retrospect and Prospect. Part 1. Selective Enzyme Inhibitors

Autor: Nikolaus Seiler

Publikováno v: Current Drug Targets. 4:537-564

As soon as the natural polyamines (PAs), putrescine (Put), spermidine (Spd) and spermine (Spm), were recognized as ubiquitous constituents of eukaryotic cells, their involvement in growth-related processes attracted particular interest. The high acti

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https://doi.org/10.2174/1389450033490885

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Ammonia and Alzheimer’s disease

Autor: Nikolaus Seiler

Publikováno v: Neurochemistry International. 41:189-207

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Behavioural, cognitive and memory dysfunctions are characteristic symptoms of AD. The formation of amyloid plaques is currently considered as the key event of AD. Oth

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https://doi.org/10.1016/s0197-0186(02)00041-4

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Autor: Francine Gossé, B. Duranton, V. Holl, Nikolaus Seiler, Yann Schneider, Francis Raul, S. Carnesecchi

Publikováno v: Cell Biology and Toxicology. 18:381-396

N 1,N 4-bis(2,3-butadienyl)-1,4-butanediamine (MDL 72527) was considered to be a selective inactivator of FAD-dependent tissue polyamine oxidase. Recently MDL 72527 was reported to induce apoptosis in transformed hematopoietic cells through lysosomot

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https://doi.org/10.1023/a:1020863506170

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Resveratrol Inhibits Intestinal Tumorigenesis and Modulates Host-Defense-Related Gene Expression in an Animal Model of Human Familial Adenomatous Polyposis

Autor: Nikolaus Seiler, Yann Schneider, Rend Schleiffer, Francine Gossé, Francis Raul, B. Duranton

Publikováno v: Nutrition and Cancer. 39:102-107

We studied the effect of oral administration of resveratrol, a natural constituent of grapes, on tumorigenesis in Min mice. Min mice are congenic mice genetically predisposed to develop intestinal tumors as a result of a mutation of the Apc gene. Res

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https://doi.org/10.1207/s15327914nc391_14

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Effect of the polyamine oxidase inactivator MDL 72527 on N1-(n-octanesulfonyl)spermine toxicity

Autor: Nikolaus Seiler, Yann Schneider, F Vincent, Francis Raul, L Badolo, Francine Gossé, B. Duranton

Publikováno v: The International Journal of Biochemistry & Cell Biology. 32:1055-1068

N 1 -(n-octanesulfonyl)spermine ( N 1 OSSpm) is a potent calmodulin antagonist. In the present work, its toxicity to DHD/K12/TRb and CaCo-2 cells, two colon carcinoma-derived cell lines, was studied with the aim to identify those properties of the ce

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https://doi.org/10.1016/s1357-2725(00)00052-2

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Autor: B. Duranton, Nikolaus Seiler, Francine Gossé, Francis Raul

Publikováno v: Cell Biology and Toxicology. 16:117-130

Spermine is a constituent of all vertebrate cells. Nevertheless, it exerts toxic effects if it accumulates in cells. Spermine is a natural substrate of the FAD-dependent polyamine oxidase, a constitutive enzyme of many cell types. It has been reporte

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https://doi.org/10.1023/a:1007642126765

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Autor: Nikolaus Seiler

Publikováno v: Neurochemical Research. 25:471-490

Several amine oxidases are involved in the metabolism of the natural polyamines putrescine, spermidine, and spermine, and play a role in the regulation of intracellular concentrations, and the elimination of these amines. Since the products of the am

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https://doi.org/10.1023/a:1007508008731

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