Zobrazeno 1 - 10
of 22 160
pro vyhledávání: '"AMPA RECEPTOR"'
Publikováno v:
Neuroglia, Vol 5, Iss 3, Pp 344-355 (2024)
Ampakines—positive allosteric modulators of AMPA-type glutamate receptors (AMPARs)—are drug candidates that have shown substantial promise in pre-clinical models of various neurodegenerative and neuropsychiatric diseases. Much of the study of amp
Externí odkaz:
https://doaj.org/article/d72c779a227f46abab644d37bca7ff45
Publikováno v:
Future Pharmacology, Vol 4, Iss 3, Pp 494-509 (2024)
Ampakines are a class of orally available positive allosteric modulators of the AMPA-glutamate receptor (AMPAR) and have therapeutic implications for neurological/neuropsychiatric disorders in which AMPAR signaling is compromised. Low-impact ampakine
Externí odkaz:
https://doaj.org/article/64ab3660dce846598b9b47f1d4571137
Autor:
Taisuke Yatomi, Dardo Tomasi, Hideaki Tani, Shinichiro Nakajima, Sakiko Tsugawa, Nobuhiro Nagai, Teruki Koizumi, Waki Nakajima, Mai Hatano, Hiroyuki Uchida, Takuya Takahashi
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/c196d65bf22948c685d61a2dd82712b9
Autor:
Taisuke Yatomi, Dardo Tomasi, Hideaki Tani, Shinichiro Nakajima, Sakiko Tsugawa, Nobuhiro Nagai, Teruki Koizumi, Waki Nakajima, Mai Hatano, Hiroyuki Uchida, Takuya Takahashi
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
Local and global functional connectivity densities (lFCD and gFCD, respectively), derived from functional magnetic resonance imaging (fMRI) data, represent the degree of functional centrality within local and global brain networks. While these method
Externí odkaz:
https://doaj.org/article/ebbf149de207435f98a684206f5a4ccd
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Amidine-containing compounds are primarily known as antiprotozoal agents (pentamidine, diminazene, furamidine) or as serine protease inhibitors (nafamostat, sepimostat, camostat, gabexate). DAPI is widely recognized as a fluorescent DNA stain. Recent
Externí odkaz:
https://doaj.org/article/72c78277071c4f0c87d7950f81705ade
Autor:
Laura Simões de Oliveira, Heather E. O’Leary, Sarfaraz Nawaz, Rita Loureiro, Elizabeth C. Davenport, Paul Baxter, Susana R. Louros, Owen Dando, Emma Perkins, Julien Peltier, Matthias Trost, Emily K. Osterweil, Giles E. Hardingham, Michael A. Cousin, Sumantra Chattarji, Sam A. Booker, Tim A. Benke, David J. A Wyllie, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause a severe neurological disorder characterised by early-onset epileptic seizures, autism and intellectual disability (ID). Impaired hippocampal function has
Externí odkaz:
https://doaj.org/article/ae255dae432e41748c4459655b5be30f
Autor:
Victor C Wong, Patrick R Houlihan, Hui Liu, Deepika Walpita, Michael C DeSantis, Zhe Liu, Erin K O'Shea
Publikováno v:
eLife, Vol 13 (2024)
AMPA-type receptors (AMPARs) are rapidly inserted into synapses undergoing plasticity to increase synaptic transmission, but it is not fully understood if and how AMPAR-containing vesicles are selectively trafficked to these synapses. Here, we develo
Externí odkaz:
https://doaj.org/article/39ed2d3ca854437b96ef9aab6e4f7da3
Autor:
Daniel Pierce Radin, Sheng Zhong, Rok Cerne, Mohammed Shoaib, Jeffrey M. Witkin, Arnold Lippa
Publikováno v:
Future Pharmacology, Vol 4, Iss 1, Pp 173-187 (2024)
AMPA-glutamate receptors (AMPARs) are expressed throughout the CNS and mediate the majority of fast excitatory synaptic transmission. Ampakines are orally available small molecules that bind allosterically to AMPARs and enhance excitatory currents el
Externí odkaz:
https://doaj.org/article/f0c6232b2cb84a4db749d1ea71f2646a
Autor:
Man Luo, Yayan Pang, Junjie Li, Lilin Yi, Bin Wu, Qiuyun Tian, Yan He, Maoju Wang, Lei Xia, Guiqiong He, Weihong Song, Yehong Du, Zhifang Dong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 635-652 (2024)
Alzheimer's disease (AD) is a leading cause of dementia in the elderly. Mitogen-activated protein kinase phosphatase 1 (MKP-1) plays a neuroprotective role in AD. However, the molecular mechanisms underlying the effects of MKP-1 on AD have not been e
Externí odkaz:
https://doaj.org/article/3c74df04a92a4e7c9d31b5922b70dbad
Publikováno v:
Neuroscience Research, Vol 198, Iss , Pp 21-29 (2024)
In the present study, we attempted to temporally and quantitatively analyze the functional contributions of Ca2+-permeable (CP) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) during long-term potentiation (LTP) expression us
Externí odkaz:
https://doaj.org/article/bad7cb3e99a8446caa9d5b0b72698d41