Zobrazeno 1 - 10
of 33
pro vyhledávání: '"AMP, antimicrobial peptide"'
Autor:
Beiyu Liu, Tarannum Jaleel, Rayan Kaakati, Amanda S. MacLeod, John Tanaka, Rachael A Ward, Cynthia L. Green
Publikováno v:
JAAD International
Background Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ce81064a7bc27618210d67497383e3
http://europepmc.org/articles/PMC8362302
http://europepmc.org/articles/PMC8362302
Autor:
Jakob Benedict Seidelin, Jens Vilstrup Johansen, Marina Ramírez Galera, Lene Riis, Tine Rask Licht, Benjamin E. Mead, Anders Woetmann, Martin Iain Bahl, Jeffrey M. Karp, Jacob Tveiten Bjerrum
Publikováno v:
Seidelin, J B, Bahl, M I, Licht, T R, Mead, B E, Karp, J M, Johansen, J V, Riis, L B, Galera, M R, Woetmann, A & Bjerrum, J T 2021, ' Acute Experimental Barrier Injury Triggers Ulcerative Colitis–Specific Innate Hyperresponsiveness and Ulcerative Colitis–Type Microbiome Changes in Humans ', Cellular and Molecular Gastroenterology and Hepatology, vol. 12, no. 4, pp. 1281-1296 . https://doi.org/10.1016/j.jcmgh.2021.06.002
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1281-1296 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1281-1296 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Background and aims The trigger hypothesis opens the possibility of anti-flare initiation therapies by stating that ulcerative colitis (UC) flares originate from inadequate responses to acute mucosal injuries. However, experimental evidence is restri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15deac621434858603c947222764fb6
https://doi.org/10.1016/j.jcmgh.2021.06.002
https://doi.org/10.1016/j.jcmgh.2021.06.002
BackgroundSeveral clinical trials of Staphylococcus aureus (S. aureus)-targeted therapies for atopic dermatitis (AD) have demonstrated conflicting results regarding whether they improve AD severity scores. This study performs a model-based meta-analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8125ee7c42e557d8145ae72dacc447f
http://hdl.handle.net/10044/1/94892
http://hdl.handle.net/10044/1/94892
Publikováno v:
JID Innovations, Vol 2, Iss 1, Pp 100064-(2022)
JID Innovations
JID Innovations
Obesity is a growing epidemic worldwide, and it is also considered a major environmental factor contributing to the pathogenesis of inflammatory skin diseases, including psoriasis (PSO) and atopic dermatitis (AD). Moreover, obesity worsens the course
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cacaa551132dbadfca2113955e3e55
http://www.sciencedirect.com/science/article/pii/S2667026721000655
http://www.sciencedirect.com/science/article/pii/S2667026721000655
Autor:
Carl G. A. Persson
Publikováno v:
The Journal of Allergy and Clinical Immunology
This review discusses in vivo airway aspects of plasma exudation in relation to current views on epithelial permeability and epithelial regeneration in health and disease. Microvascular-epithelial exudation of bulk plasma proteins characteristically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed57dcbeb7686fb840242f8a7687356
https://doi.org/10.1016/j.jaci.2018.07.037
https://doi.org/10.1016/j.jaci.2018.07.037
Autor:
Laura Rossi, Waliul I. Khan, Jean-Eric Ghia, Steve P. Bernier, Stephen M. Collins, Emmanuel Denou, Suhrid Banskota, Md. Sharif Shajib, Michelle E. Fontes, Huaqing Wang, Yun Han Kwon, Michael G. Surette
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 709-728 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme for 5-HT synthesis in EC cells. Accumulating evidence sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d7b958a4788fee643381de67358945
https://doi.org/10.1016/j.jcmgh.2019.01.004
https://doi.org/10.1016/j.jcmgh.2019.01.004
Host defence and parasite pathogenicity interactions determine infection outcomes. Antimicrobial peptides (AMPs) are conserved components of immune defences of multicellular organisms. In this thesis, the fitness costs of the evolution of resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb0b1df6c0f31c914ec4f9f6735bfc5
Publikováno v:
Medicine in Drug Discovery
Medicine in Drug Discovery, Vol 9, Iss, Pp 100078-(2021)
Medicine in Drug Discovery, Vol 9, Iss, Pp 100078-(2021)
This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8aaa4f85cc11aaca8bc7a435085ae18
https://pubmed.ncbi.nlm.nih.gov/33398258
https://pubmed.ncbi.nlm.nih.gov/33398258
Autor:
Christian Bogdan
Publikováno v:
Cytokine
Cytokine: X, Vol 2, Iss 4, Pp 100041-(2020)
Cytokine: X, Vol 2, Iss 4, Pp 100041-(2020)
Highlights • Macrophages serve as replicative niche, antimicrobial effectors or immunoregulators. • Functional diversity results from cytokines, micromilieu factors and metabolites. • Micro milieu factors include hypoxia, tonicity and amino aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c346b1974962b6f0934f117cb72355
https://pubmed.ncbi.nlm.nih.gov/33604563
https://pubmed.ncbi.nlm.nih.gov/33604563
Autor:
Williams, Helen, Crompton, Rachel A., Thomason, Helen A., Campbell, Laura, Singh, Gurdeep, McBain, Andrew J., Cruickshank, Sheena M., Hardman, Matthew J.
Publikováno v:
The Journal of Investigative Dermatology
The skin microbiome exists in dynamic equilibrium with the host, but when the skin is compromised, bacteria can colonize the wound and impair wound healing. Thus, the interplay between normal skin microbial interactions versus pathogenic microbial in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99974dd6608c71ba4a7778805848000d
http://europepmc.org/articles/PMC5646944
http://europepmc.org/articles/PMC5646944