ERK Phosphorylation Regulates the Aml1/Runx1 Splice Variants and the TRP Channels Expression during the Differentiation of Glioma Stem Cell Lines

Autor: Giorgio Santoni, Massimo Nabissi, Consuelo Amantini, Matteo Santoni, Lucia Ricci-Vitiani, Roberto Pallini, Federica Maggi, Maria Beatrice Morelli

Publikováno v: Cells, Vol 10, Iss 8, p 2052 (2021)

The identification of cancer stem cells in brain tumors paved the way for new therapeutic approaches. Recently, a role for the transcriptional factor Runx1/Aml1 and the downstream ion channel genes in brain cancer development and progression has been

Externí odkaz: https://doaj.org/article/38bd1a5b10fd4271bf4a3e0233a52602

KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility

Autor: Hisayuki Amano, Masahiko Honda, Akiyoshi Komuro, Takeshi Ueda, Masahito Kawazu, Akinori Kanai, Kazushige Ota, Hitoshi Okada

Publikováno v: FASEB BioAdvances, Vol 3, Iss 12, Pp 1020-1033 (2021)
FASEB BioAdvances

Epigenetic alterations of chromatin structure affect chromatin accessibility and collaborate with genetic alterations in the development of cancer. Lysine demethylase 4B (KDM4B) has been identified as a JmjC domain‐containing epigenetic modifier th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24841aa5aeb1ee4572bc9c2b7e2c5426
https://doaj.org/article/5926bec7943c4cc888c811f78ca73aa2

Runx1 promotes proliferation and neuronal differentiation in adult mouse neurosphere cultures

Autor: T.T. Logan, M. Rusnak, A.J. Symes

Publikováno v: Stem Cell Research, Vol 15, Iss 3, Pp 554-564 (2015)

Traumatic brain injury alters the signaling environment of the adult neurogenic niche and may activate unique proliferative cell populations that contribute to the post-injury neurogenic response. Runx1 is not normally expressed by adult neural stem

Externí odkaz: https://doaj.org/article/b54756ab76e2478a9543f90e7afc4450

Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia

Autor: Jakobczyk, Hélène, Debaize, Lydie, Soubise, Benoit, Avner, Stéphane, Rouger-Gaudichon, Jérémie, Commet, Séverine, Jiang, Yan, Sérandour, Aurélien A., Rio, Anne-Gaëlle, Carroll, Jason S., Wichmann, Christian, Lie-a-Ling, Michael, Lacaud, Georges, Corcos, Laurent, Salbert, Gilles, Galibert, Marie-Dominique, Gandemer, Virginie, Troadec, Marie-Bérengère

Publikováno v: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-17 (2021)
Journal of Hematology & Oncology
Journal of Hematology and Oncology
Journal of Hematology and Oncology, 2021, 14 (1), pp.47. ⟨10.1186/s13045-021-01051-z⟩
Journal of Hematology and Oncology, BioMed Central, 2021, 14, pp.47. ⟨10.1186/s13045-021-01051-z⟩
BASE-Bielefeld Academic Search Engine

Background: B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is the most common pediatric cancer. Identifying key players involved in proliferation of BCP-ALL cells is crucial to propose new therapeutic targets. Runt Related Transcription Fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::be3f951daa53703c7202268b8f26f6aa
https://doaj.org/article/3e5be24cee0f4d4db6d0258b58f9a08b

Identification of a novel circularized transcript of the AML1 gene

Autor: Ai-ning Xu, Xiu-hua Chen, Yan-hong Tan, Xi-ling Qi, Zhi-fang Xu, Lin-lin Zhang, Fang-gang Ren, Si-cheng Bian, Yi Chen, Hong-wei Wang

Publikováno v: BMB Reports, Vol 46, Iss 3, Pp 163-168 (2013)

The AML1 gene is an essential transcription factor regulatingthe differentiation of hematopoietic stem cells into matureblood cells. Though at least 12 different alternatively splicedAML1 mRNAs are generated, three splice variants (AML1a,AML1b and AM

Externí odkaz: https://doaj.org/article/4ef162d5d65b41499775342117657e9f