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Molecular characterization of AML‐MRC reveals TP53 mutation as an adverse prognostic factor irrespective of MRC‐defining criteria, TP53 allelic state, or TP53 variant allele frequency

Autor: Davidson Zhao, Entsar Eladl, Mojgan Zarif, José‐Mario Capo‐Chichi, Andre Schuh, Eshetu Atenafu, Mark Minden, Hong Chang

Publikováno v: Cancer Medicine, Vol 12, Iss 6, Pp 6511-6522 (2023)

Abstract Background Acute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) generally confers poor prognosis, however, patient outcomes are heterogeneous. The impact of TP53 allelic state and variant allele frequency (VAF) in AML‐M

Externí odkaz: https://doaj.org/article/6f54f92f63484ca5b7485ba8f700b7ea

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ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia‐related changes and normal karyotype

Autor: Concepción Prats‐Martín, Sergio Burillo‐Sanz, Rosario M. Morales‐Camacho, Olga Pérez‐López, Milagros Suito, Maria T. Vargas, Teresa Caballero‐Velázquez, Estrella Carrillo‐Cruz, José González, Ricardo Bernal, José A. Pérez‐Simón

Publikováno v: Cancer Medicine, Vol 9, Iss 11, Pp 3637-3646 (2020)

Abstract Acute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) are poor outcome leukemias. Its diagnosis is based on clinical, cytogenetic, and cytomorphologic criteria, last criterion being sometimes difficult to assess. A high fr

Externí odkaz: https://doaj.org/article/f43c49145b2a442d9b8b572ba497bc8a

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Akademický článek

Patients with AML-MRC benefit from decitabine in combination with low-dose G-CSF, cytarabine and aclarubicin: A single center cohort study

Autor: Jing Liu, Xiaohong Liu, Jinsong Jia, Lizhong Gong, Shengye Lu, Jing Wang, Xiao-jun Huang, Hao Jiang

Publikováno v: Leukemia Research Reports, Vol 18, Iss , Pp 100354- (2022)

Patients with acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) are insensitive to conventional chemotherapy and, therefore, have a poor prognosis. To evaluate the clinical efficacy and safety of low-dose decitabine in combination

Externí odkaz: https://doaj.org/article/e4f233c2e0004f4192a741e9d62caeab

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Case Report: Allogeneic Stem Cell Transplantation Following Induction With CPX-351 in Patients With Acute Myeloid Leukemia Is Feasible

Autor: Vucinic, Vladan, Jentzsch, Madlen, Schwind, Sebastian, Bach, Enrica, Leiblein, Sabine, Remane, Yvonne, Rieprecht, Susanne, Otto, Sandra, Kubasch, Anne-Sophie, Behre, Gerhard, Cross, Michael, Platzbecker, Uwe, Franke, Georg-Nikolaus

Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and treatment-related acutemyeloid leukemia (tAML) after chemotherapy or radiation therapy for other neoplasms are associated with poor outcomes. CPX-351, a dual-drug liposomal enca

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A84204
https://ul.qucosa.de/api/qucosa%3A84204/attachment/ATT-0/

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Akademický článek

Case Report: Allogeneic Stem Cell Transplantation Following Induction With CPX-351 in Patients With Acute Myeloid Leukemia Is Feasible

Autor: Vladan Vucinic, Madlen Jentzsch, Sebastian Schwind, Enrica Bach, Sabine Leiblein, Yvonne Remane, Susanne Rieprecht, Sandra Otto, Anne-Sophie Kubasch, Gerhard Behre, Michael Cross, Uwe Platzbecker, Georg-Nikolaus Franke

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and treatment-related acute myeloid leukemia (tAML) after chemotherapy or radiation therapy for other neoplasms are associated with poor outcomes. CPX-351, a dual-drug liposomal enc

Externí odkaz: https://doaj.org/article/69d0cff447fa42e696b2796fd0efb84b

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Akademický článek

Azacitidine improves clinical outcomes in older patients with acute myeloid leukaemia with myelodysplasia-related changes compared with conventional care regimens

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-13 (2017)

Abstract Background Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenet

Externí odkaz: https://doaj.org/article/8383b31ab3964040a696c4af7281e2f3

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Akademický článek

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ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia-related changes and normal karyotype

Autor: Milagros Suito, José A. González, José Antonio Pérez-Simón, Olga Pérez‐López, Maria T. Vargas, Rosario M. Morales-Camacho, Teresa Caballero-Velázquez, Ricardo Bernal, Concepción Prats-Martín, Sergio Burillo-Sanz, Estrella Carrillo-Cruz

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Cancer Medicine
Cancer Medicine, Vol 9, Iss 11, Pp 3637-3646 (2020)

Acute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) are poor outcome leukemias. Its diagnosis is based on clinical, cytogenetic, and cytomorphologic criteria, last criterion being sometimes difficult to assess. A high frequency o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b851a7bc68e645afa0626ade03ce4ea
https://hdl.handle.net/10668/15288

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