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pro vyhledávání: '"AMG900"'
Autor:
Geron, Lenisa
O meduloblastoma (MB) é o tumor cerebral maligno mais comum na infância. A formação/progressão desta neoplasia foi associada a alterações moleculares, que inclui a desregulação da via de sinalização Wingless (Wnt), responsável pelo desenv
Publikováno v:
In Chemico-Biological Interactions 25 January 2021 334
Publikováno v:
Cancer Medicine. Nov2018, Vol. 7 Issue 11, p5589-5603. 15p.
Publikováno v:
Cancer Medicine, Vol 7, Iss 11, Pp 5589-5603 (2018)
Abstract The Aurora kinase family of serine/threonine protein kinases comprises Aurora A, B, and C and plays an important role in mitotic progression. Several inhibitors of Aurora kinase have been developed as anti‐cancer therapeutics. Here, we exa
Externí odkaz:
https://doaj.org/article/64a3a0ea20a64674ad56d5534c686478
Autor:
Lenisa Geron
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
O meduloblastoma (MB) é o tumor cerebral maligno mais comum na infância. A formação/progressão desta neoplasia foi associada a alterações moleculares, que inclui a desregulação da via de sinalização Wingless (Wnt), responsável pelo desenv
Publikováno v:
Chemico-Biological Interactions. 334:109349
Introduction Cancer is one of the leading causes of death worldwide. Classical cytotoxic chemotherapy exerts high side effects and low tumor selectivity. Translationally controlled tumor protein (TCTP) is a target for differentiation therapy, a promi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6380eb7caddaad346d70560891b1523b
https://doi.org/10.1016/j.cbi.2020.109349
https://doi.org/10.1016/j.cbi.2020.109349
Autor:
Lenisa Geron
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
O meduloblastoma (MB) é o tumor cerebral maligno mais comum na infância. A formação/progressão desta neoplasia foi associada a alterações moleculares, que inclui a desregulação da via de sinalização Wingless (Wnt), responsável pelo desenv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0508587ef0fa4c2fd5d76e24c28dc8db
https://doi.org/10.11606/d.17.2017.tde-04012017-095955
https://doi.org/10.11606/d.17.2017.tde-04012017-095955
Autor:
Vanessa da Silva Silveira, Augusto Faria Andrade, David S. Marco Antonio, Luiz Gonzaga Tone, Kleiton Silva Borges, Carlos Alberto Scrideli, Elton J R Vasconcelos, Sonir Roberto Rauber Antonini
Publikováno v:
Molecular Cancer Therapeutics. 12:A294-A294
Pediatric adrenocortical tumors (ACT) are rare malignancies and in advanced disease the treatment has a small impact on overall survival. Previous study from our group suggests that AURKA and AURKB overexpression in pediatric ACT may be related to mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e50f2ca4de620537398718ecd0753885
https://doi.org/10.1158/1535-7163.targ-13-a294
https://doi.org/10.1158/1535-7163.targ-13-a294
Autor:
Hans J. Hammers, Michael A. Carducci, Channing J. Paller, Eugene Kim, Charles M. Rudin, Michel D. Wissing, Sushant Kachhap
Publikováno v:
Cancer Research. 72:2049-2049
Background: Histone deacetylase (HDAC) enzymes maintain the structural conformation of chromatin. Inhibition of HDACs induces G1 arrest and differentiation. Previous microarray analysis demonstrated downregulation of the aurora kinase-pathway in pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0896fb23dd66d33d1117f641794401
https://doi.org/10.1158/1538-7445.am2012-2049
https://doi.org/10.1158/1538-7445.am2012-2049
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