Zobrazeno 1 - 10
of 53
pro vyhledávání: '"AMAP1"'
Autor:
Hisataka Sabe
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-7 (2023)
Abstract Mutations in the KRAS gene and overexpression of protein products of the MYC and ARF6 genes occur frequently in cancer. Here, the inseparable relationships and cooperation of the protein products of these three genes in cancer malignancy and
Externí odkaz:
https://doaj.org/article/1fde4a7594d2440984b5af0c0a06f537
Autor:
Ari Hashimoto, Haruka Handa, Soichiro Hata, Akio Tsutaho, Takao Yoshida, Satoshi Hirano, Shigeru Hashimoto, Hisataka Sabe
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-6 (2021)
Abstract Many clinical trials are being conducted to clarify effective combinations of various drugs for immune checkpoint blockade (ICB) therapy. However, although extensive studies from multiple aspects have been conducted regarding treatments for
Externí odkaz:
https://doaj.org/article/dbfb93df140d4c7ab28c2b2961b9b8c2
Autor:
Akio Tsutaho, Ari Hashimoto, Shigeru Hashimoto, Soichiro Hata, Shion Kachi, Satoshi Hirano, Hisataka Sabe
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-8 (2020)
Abstract Background Not merely the onset of immune evasion, but other factors, such as acidosis and fibrosis, are also major barriers in cancer therapeutics. Dense fibrosis is a hallmark of pancreatic ductal carcinoma (PDAC), in which hyperactivation
Externí odkaz:
https://doaj.org/article/3ce037da199844bea7fab528f573572d
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
PurposeWe examined the diagnostic significance, prognostic value, and potential function of AMAP1 in gastric cancer (GC).MethodsComprehensive bioinformatic analysis was conducted to investigate differential expression of AMAP1 mRNA and protein in GC.
Externí odkaz:
https://doaj.org/article/3608bb1520834c0cba0f34e4a4127644
Autor:
Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa, Hisataka Sabe
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-8 (2018)
Abstract Background TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essential for the ARF6-
Externí odkaz:
https://doaj.org/article/bf3fd7548df74fcb8773972213da6c6d
Autor:
Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, Shigeru Hashimoto, Haruka Handa, Hiroki Yamamoto, Ari Hashimoto, Hisataka Sabe
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRKD2, EPB41L5, paxillin
Externí odkaz:
https://doaj.org/article/c6ca8b57c90341baaf1cc101ba342cf7
Autor:
Ari Hashimoto, Shigeru Hashimoto, Shion Kachi, Satoshi Hirano, Hisataka Sabe, Akio Tsutaho, Soichiro Hata
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-8 (2020)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Background Not merely the onset of immune evasion, but other factors, such as acidosis and fibrosis, are also major barriers in cancer therapeutics. Dense fibrosis is a hallmark of pancreatic ductal carcinoma (PDAC), in which hyperactivation of focal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99459661c1a7af76d037ee322770944
http://link.springer.com/article/10.1186/s12964-020-00608-8
http://link.springer.com/article/10.1186/s12964-020-00608-8
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics
Frontiers in Genetics
PurposeWe examined the diagnostic significance, prognostic value, and potential function of AMAP1 in gastric cancer (GC).MethodsComprehensive bioinformatic analysis was conducted to investigate differential expression of AMAP1 mRNA and protein in GC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def2406b24135625eaaf8f3a53732f82
https://doi.org/10.3389/fgene.2021.675100
https://doi.org/10.3389/fgene.2021.675100
Publikováno v:
Translational Oncology
Translational Oncology, Vol 15, Iss 1, Pp 101258-(2022)
Translational Oncology, Vol 15, Iss 1, Pp 101258-(2022)
Highlights • The AMAP1-PRKD2 pathway regulates the intracellular trafficking of CAIX. • The AMAP1-PIAS3 pathway stabilizes HIF-1α and promotes the transcription of CAIX. • High ASAP1 together with high PIAS3 correlates with high CA9 in breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c57043e219f7342c5e82dd3bfaf6bf
http://hdl.handle.net/2115/84125
http://hdl.handle.net/2115/84125
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