Does usnic acid affect microtubules in human cancer cells?

Autor: MA. O'Neill, M. Mayer, KE. Murray, HML. Rolim-Santos, NS. Santos-Magalhães, AM. Thompson, VCL. Appleyard

Publikováno v: Brazilian Journal of Biology, Vol 70, Iss 3, Pp 659-664

Usnic acid, a lichen metabolite, is known to exert antimitotic and antiproliferative activities against normal and malignant human cells. Many chemotherapy agents exert their activities by blocking cell cycle progression, inducing cell death through

Externí odkaz: https://doaj.org/article/269428ef57f249e2935faaf1dd702cd7

Abstract P1-07-11: Improved long term survival from breast cancer over three decades: Persistent disparities with age, but not socioeconomic status, in a socialized heath care system

Autor: A Ashfield, Colin A. Purdie, AM Thompson, Lee B. Jordan, A Malin

Publikováno v: Cancer Research. 76:P1-07

Background Socioeconomic status and patient age have been associated with disparities in survival for breast cancer. We previously reported breast cancer diagnosed in a geographically defined population treated in a single cancer center in a socializ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20cb18731b5e502a711d888879ae550a
https://doi.org/10.1158/1538-7445.sabcs15-p1-07-11

Abstract P4-15-01: Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy

Autor: Jane Warwick, P Quinlan, William J. Tapper, Diana Eccles, Lee B. Jordan, P Chou, C Gillet, Antonio Saha, Shelia M. Violette, Jane Kendrew, AM Thompson, Stephen W. Duffy, R L Bowen, Andrew R. Green, Simon T. Barry, A Brentall, Rhian Gabe, Ian O. Ellis, Kate Moore, John Marshall, Ian R. Hart, S. Vallath, Kellie Brouilette, Gareth J. Thomas, JL Jones, Claude Chelala, Syed Haider, Paul H. Weinreb

Publikováno v: Cancer Research. 73:P4-15

The integrin avβ6 promotes migration, invasion and survival of cancer cells, but the biological relevance has yet to be ascertained in breast cancer. Our immunhistochemical analysis of over 2000 breast cancers has revealed that high expression of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44732d5e8a4caea6971d2f4c90a1551e
https://doi.org/10.1158/0008-5472.sabcs13-p4-15-01

Endocranial volume is heritable and is associated with longevity and fitness in a wild mammal

Autor: Leb Kruuk, Corina J. Logan, Tim H. Clutton-Brock, R Stanley, AM Thompson

Publikováno v: Royal Society Open Science
Royal Society Open Science, Vol 3, Iss 12 (2016)
Logan, C J, Kruuk, L E B, Stanley, R, Thompson, A M & Clutton-Brock, T H 2016, ' Endocranial volume is heritable and is associated with longevity and fitness in a wild mammal ', Royal Society Open Science, vol. 3, no. 12, 160622 . https://doi.org/10.1098/rsos.160622

Research on relative brain size in mammals suggests that increases in brain size may generate benefits to survival and costs to fecundity: comparative studies of mammals have shown that interspecific differences in relative brain size are positively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18071d08339562e9656ef269caaacd1f
https://hdl.handle.net/21.11116/0000-0003-C5DB-821.11116/0000-0003-C5DD-621.11116/0000-0003-C5DE-5

P3-12-04: Involved Anterior Margins after Breast Conserving Surgery: Is Re-Excision Required?

Autor: Lee B. Jordan, E.J. Macaskill, Colin A. Purdie, AM Thompson, R Mullen, E. Elseedawy, A. C. Lee, Douglas C. Brown, A. Khalil

Publikováno v: Cancer Research. 71:P3-12

Background: Complete tumour excision in breast conserving surgery (BCS) is critical for successful treatment; involved circumferential resection margins are associated with increased disease recurrence. However, the importance of an involved anterior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4612475e78bf42deb16bfd449aa7e39
https://doi.org/10.1158/0008-5472.sabcs11-p3-12-04