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Polymorphic Variants in NR1I3 and UGT2B7 Predict Taxane Neurotoxicity and Have Prognostic Relevance in Patients With Breast Cancer: A Case-Control Study

Autor: Arbitrio, Mariamena, Scionti, Francesca, Altomare, Emanuela, Di Martino, Maria Teresa, Agapito, Giuseppe, Galeano, Teresa, Staropoli, Nicoletta, Iuliano, Eleonora, Grillone, Francesco, Fabiani, Fernanda, Caracciolo, Daniele, Cannataro, Mario, Arpino, Grazia, Santini, Daniele, Tassone, Pierfrancesco, Tagliaferri, Pierosandro

Taxane-related peripheral neuropathy (TrPN) is a dose-limiting toxicity with important interindividual variability. Genetic polymorphisms in absorption, distribution, metabolism, and excretion (ADME) genes may account for variability in drug efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::7e242f1aef0c546a2f84947c3a0eca33
http://hdl.handle.net/11588/890670

DMET(TM) Genotyping: Tools for Biomarkers Discovery in the Era of Precision Medicine

Autor: Agapito Giuseppe, Settino Marzia, Scionti Francesca, Altomare Emanuela, Guzzi Pietro Hiram, Tassone Pierfrancesco, Tagliaferri Pierosandro, Cannataro Mario, Arbitrio Mariamena, Di Martino Maria Teresa

Publikováno v: High-throughput Online 9 (2020). doi:10.3390/ht9020008.
info:cnr-pdr/source/autori:Agapito Giuseppe; Settino Marzia; Scionti Francesca; Altomare Emanuela; Guzzi Pietro Hiram; Tassone Pierfrancesco; Tagliaferri Pierosandro; Cannataro Mario; Arbitrio Mariamena; Di Martino Maria Teresa;/titolo:DMET(TM) Genotyping: Tools for Biomarkers Discovery in the Era of Precision Medicine/doi:10.3390%2Fht9020008./rivista:High-throughput Online/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:9

The knowledge of genetic variants in genes involved in drug metabolism may be translated into reduction of adverse drug reactions, increase of efficacy, healthcare outcomes improvement and economic benefits. Many high-throughput tools are available f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::d42656ee8ea280391e0e56516b43ef66
http://www.cnr.it/prodotto/i/420476

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Polymorphic variants in NR1I3 and UGT2B7 predict taxane neurotoxicity and have prognostic relevance in breast cancer patients: a case-control study

Autor: Arbitrio Mariamena (1), Scionti Francesca (2), Altomare Emanuela (2), Di Martino Maria Teresa (2), Agapito Giuseppe (3), Galeano Teresa (2), Staropoli Nicoletta (4), Iuliano Eleonora(2), Grillone rancescaF (4), Fabiani Fernanda (5), Caracciolo Daniele (2), Cannataro Mario (3), Arpino Grazia (6), Santini Daniele (7), Tassone Pierfrancesco (2, Tagliaferri Pierosandro (2

Publikováno v: Clinical pharmacology and therapeutics (2019). doi:10.1002/cpt.1391
info:cnr-pdr/source/autori:Arbitrio Mariamena (1), Scionti Francesca (2), Altomare Emanuela (2), Di Martino Maria Teresa (2), Agapito Giuseppe (3), Galeano Teresa (2), Staropoli Nicoletta (4), Iuliano Eleonora(2), Grillone rancescaF (4), Fabiani Fernanda (5), Caracciolo Daniele (2), Cannataro Mario (3), Arpino Grazia (6), Santini Daniele (7), Tassone Pierfrancesco (2,3), Tagliaferri Pierosandro (2,3)/titolo:Polymorphic variants in NR1I3 and UGT2B7 predict taxane neurotoxicity and have prognostic relevance in breast cancer patients: a case-control study/doi:10.1002%2Fcpt.1391/rivista:Clinical pharmacology and therapeutics/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume

Taxane-related peripheral neuropathy (TrPN) is a dose-limiting toxicity with important inter-individual variability. Genetic polymorphisms in ADME genes may account for variability in drug efficacy and/or toxicity. By the use of Affymetrix DMETTM mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::d8a7c37c277d69dd8ee4c57f8162802b
https://publications.cnr.it/doc/399806