Zobrazeno 1 - 10
of 3 918
pro vyhledávání: '"ALTERNATIVE PATHWAY"'
Autor:
Fridkis-Hareli M; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Storek M; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Or E; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Altman R; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Katti S; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Sun F; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Peng T; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Hunter J; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Johnson K; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Wang Y; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Lundberg AS; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Mehta G; Division of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA., Banda NK; Division of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA. Electronic address: Nirmal.Banda@UCDenver.edu., Michael Holers V; Division of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Publikováno v:
Molecular immunology [Mol Immunol] 2019 Jan; Vol. 105, pp. 150-164. Date of Electronic Publication: 2018 Dec 01.
Autor:
Pedersen H; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Jensen RK; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Hansen AG; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Petersen SV; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Thiel S; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Laursen NS; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Andersen GR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Publikováno v:
Frontiers in immunology [Front Immunol] 2022 Jul 22; Vol. 13, pp. 872536. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).
Autor:
Bettoni S; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo., Bresin E; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo., Remuzzi G; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo, the Azienda Ospedaliera Papa Giovanni XXIII, Unit of Nephrology and Dialysis, 24127 Bergamo, and the Department of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy., Noris M; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo, marina.noris@marionegri.it., Donadelli R; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo.
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2016 Apr 08; Vol. 291 (15), pp. 8214-30. Date of Electronic Publication: 2016 Feb 22.
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Introduction Acute lung injury (ALI) as one kind of acute pulmonary inflammatory disorder, manifests primarily as damage to alveolar epithelial cells and microvascular endothelial cells. Activation of the complement system is a common pathol
Externí odkaz:
https://doaj.org/article/bea1ffef60b24ebc8b509a88910b0bc7
Autor:
Michels MAHM; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands., van de Kar NCAJ; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands., van Kraaij SAW; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Sarlea SA; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands., Gracchi V; Department of Pediatric Nephrology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Engels FAPT; Department of Pediatric Nephrology, Maastricht University Medical Center+, Maastricht, Netherlands., Dorresteijn EM; Department of Pediatric Nephrology, Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, Netherlands., van der Deure J; Department of Pediatrics, Deventer Hospital, Deventer, Netherlands., Duineveld C; Department of Nephrology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Wetzels JFM; Department of Nephrology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands., van den Heuvel LPWJ; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Pediatrics/Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium.; Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium., Volokhina EB; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Publikováno v:
Frontiers in immunology [Front Immunol] 2021 Aug 11; Vol. 12, pp. 715704. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2021).
Autor:
Nelly Candela, Nicolas Benichou, Mathilde Lefebvre, Lorraine Gueguen, Paula Vieira-Martins, Carine El Sissy, Hervé Sartelet, Pascale Testevuide, Ronan Delaval, Stanislas Faguer
Publikováno v:
Journal of Translational Autoimmunity, Vol 9, Iss , Pp 100254- (2024)
Objective: To compare the natural history of C3 glomerulopathy (C3G) to acute post-infectious glomerulonephritis (APIGN) in a cohort of patients with a relative homogeneity of environment conditions and genetic background. Methods: We retrospectively
Externí odkaz:
https://doaj.org/article/b3359aaed40943c3bb2be8b773b8ee01
Autor:
Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
The bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously.
Externí odkaz:
https://doaj.org/article/753bc6a4e1c84f36a3a965b0c849a86b
Autor:
Karin Heidenreich, Deepti Goel, P. S. Priyamvada, Sagar Kulkarni, Vipul Chakurkar, Dinesh Khullar, Ravi Singh, Charan Bale, Peter F. Zipfel
Publikováno v:
Frontiers in Nephrology, Vol 4 (2024)
C3 glomerulopathy (C3G) is an ultra-rare complement-mediated kidney disease caused by to the deregulation of the alternative pathway (AP) of proximal complement. Consequently, all effector loops of the complement are active and can lead to pathologie
Externí odkaz:
https://doaj.org/article/b8df9dbc8a8e4fb69f815ce532d9d682
Autor:
Berends ET; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands., Gorham RD Jr; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands., Ruyken M; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands., Soppe JA; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands., Orhan H; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands., Aerts PC; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands., de Haas CJ; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands., Gros P; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.; Department of Chemistry, Faculty of Science, Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands., Rooijakkers SH; Medical Microbiology, University Medical Center Utrecht, PO G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. s.h.m.rooijakkers@umcutrecht.nl.
Publikováno v:
BMC biology [BMC Biol] 2015 Nov 09; Vol. 13, pp. 93. Date of Electronic Publication: 2015 Nov 09.