Zobrazeno 1 - 10 of 47 pro vyhledávání: '"ALPHA-CARDIAC ACTIN"'
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PATH-14. ALPHA CARDIAC ACTIN EXPRESSION IS OBSERVED IN AGGRESSIVE GLIOMA SUBTYPES AND GLIOBLASTOMA STEM CELLS
Autor: Rahul Suresh, Roberto J. Diaz, Sophie Fiola, Jamie Beaulieu
Publikováno v: Neuro Oncol
BACKGROUND Alterations in actin subunit expression have previously been observed in multiple cancers. In glioblastoma (GBM), the expression of ACTC1 has been associated with a more invasive phenotype and with shorter survival. We sought to explore th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563f5ed80287fc9d4ac04813a8e4d3ac
https://europepmc.org/articles/PMC8598492/
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2
Regulatory changes in the α-cardiac actin variants H88Y and F90Δ implicated in early-onset hypertrophic cardiomyopathy
Autor: Shaikh, Zeeshan
Cardiovascular disease (CVD) impacts millions of lives affecting 1 in 12 Canadians over the age of 20 between 2012 and 2013. A commonly inherited CVD called Hypertrophic cardiomyopathy (HCM) is defined by an increase in ventricular wall thickness. Li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______453::e977015f31371f35b889ea3993c9f0bf
https://hdl.handle.net/10214/14728
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3
Isogenic pairs of hiPSC-CMs with hypertrophic cardiomyopathy/LVNC-associated ACTC1 E99K mutation unveil differential functional deficits
Autor: Smith, JGW, Owen, T, Bhagwan, JR, Mosqueira, D, Scott, E, Mannhardt, I, Patel, A, Barriales-Villa, R, Monserrat, L, Hansen, A, Eschenhagen, T, Harding, SE, Marston, S, Denning, C
Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 11, Iss 5, Pp 1226-1243 (2018)
Summary Hypertrophic cardiomyopathy (HCM) is a primary disorder of contractility in heart muscle. To gain mechanistic insight and guide pharmacological rescue, this study models HCM using isogenic pairs of human induced pluripotent stem cell-derived
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ca7053bfe3af6e7478516299c99fadab
https://ueaeprints.uea.ac.uk/id/eprint/69494/
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4
Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I
Autor: J.-P. Jin, Hongguang Wei, Han Zhong Feng, Stephanie Kern, Steven E. Cala
Publikováno v: FEBS Open Bio
FEBS Open Bio, Vol 4, Iss C, Pp 11-17 (2014)
We previously reported that a restrictive N-terminal truncation of cardiac troponin I (cTnI-ND) is up-regulated in the heart in adaptation to hemodynamic stresses. Over-expression of cTnI-ND in the hearts of transgenic mice revealed functional benefi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2b7e484f28dcbdcd34b2838d57ca89
https://doi.org/10.1016/j.fob.2013.11.002
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6
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8
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9
Effects of cardiomyopathy linked mutations on folding, stability, and polymerization of human alpha-carrdiac actin
Autor: Mundia, Maureen M.
The causal link between missense mutations in the human cardiac alpha-actin gene ('ACTC') and cardiac muscle disease phenotypes including hypertrophic and dilated cardiomyopathy has been well established. However, the molecular mechanisms by which di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______453::f4a8d354c5d61ea59196c65d08b35a25
https://hdl.handle.net/10214/22314
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Plný text Recenzováno Digitální knihovna AV ČR
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