Zobrazeno 1 - 10
of 6 145
pro vyhledávání: '"ALLOSTERY"'
Autor:
Andre J. Faure, Ben Lehner
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract We present MoCHI, a tool to fit interpretable models using deep mutational scanning data. MoCHI infers free energy changes, as well as interaction terms (energetic couplings) for specified biophysical models, including from multimodal phenot
Externí odkaz:
https://doaj.org/article/2fa79b0b87d44dd4ba3f6222a5e82f13
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3118-3131 (2024)
The gene PIK3CA, encoding the catalytic subunit p110α of PI3Kα, is the second most frequently mutated gene in cancer, with the highest frequency oncogenic mutants occurring in the C-terminus of the kinase domain. The C-terminus has a dual function
Externí odkaz:
https://doaj.org/article/fb12b9be2c5242a0880c041b2806ad1a
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-29 (2024)
Abstract A crucial mechanism for controlling the actions of proteins is allostery. Allosteric modulators have the potential to provide many benefits compared to orthosteric ligands, such as increased selectivity and saturability of their effect. The
Externí odkaz:
https://doaj.org/article/3a8037ccea0f4fe8b224105974c350cd
Autor:
Lei Lei, Zachary Frome Burton
Publikováno v:
DNA, Vol 4, Iss 3, Pp 252-275 (2024)
The three 31 nucleotide minihelix tRNA evolution theorem describes the evolution of type I and type II tRNAs to the last nucleotide. In databases, type I and type II tRNA V loops (V for variable) were improperly aligned, but alignment based on the th
Externí odkaz:
https://doaj.org/article/8b97f6e9330541dd971cbf7fae8a85f6
Publikováno v:
FEBS Open Bio, Vol 14, Iss 7, Pp 1040-1056 (2024)
Allostery is an important property of biological macromolecules which regulates diverse biological functions such as catalysis, signal transduction, transport, and molecular recognition. However, the concept was expressed using two different definiti
Externí odkaz:
https://doaj.org/article/d3c6b31f75a04e8db1ec4dcd8b008f2f
Publikováno v:
eLife, Vol 13 (2024)
Agonists enhance receptor activity by providing net-favorable binding energy to active over resting conformations, with efficiency (η) linking binding energy to gating. Previously, we showed that in nicotinic receptors, η-values are grouped into fi
Externí odkaz:
https://doaj.org/article/d8d6d6a370fa4ab58f2e2f8a22bd7eee
Publikováno v:
eLife, Vol 13 (2024)
Cyclic nucleotide-binding domain (CNBD) ion channels play crucial roles in cellular-signaling and excitability and are regulated by the direct binding of cyclic adenosine- or guanosine-monophosphate (cAMP, cGMP). However, the precise allosteric mecha
Externí odkaz:
https://doaj.org/article/91687f82a3da4a84895babe9c209a18e
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
In this work, we report the discovery of potent anti-epidermal growth factor receptor (EGFR) allosteric heavy-chain antibodies by combining camelid immunization and fluorescence-activated cell sorting (FACS). After immunization and yeast surface disp
Externí odkaz:
https://doaj.org/article/47ecdc7002cb4c918adba46e3118162a
Publikováno v:
Exploration of Immunology, Vol 4, Iss 3, Pp 325-332 (2024)
As the most severe novel infectious disease in this century, coronavirus disease 2019 (COVID-19) faces tremendous challenges due to the hysteresis of drugs and vaccine development. Elucidating the panoramic mechanism of coronavirus-host immune intera
Externí odkaz:
https://doaj.org/article/2eb985fb47fc41119d1eb45d8c338596