Zobrazeno 1 - 10
of 1 146
pro vyhledávání: '"ALKBH5"'
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Centrosomal protein of 55 kDa (CEP55) overexpression has been linked to tumor stage, aggressiveness of the tumor, poor prognosis, and metastasis. This study aims to elucidate the action of CEP55 in ovarian cancer (OC) and the regu
Externí odkaz:
https://doaj.org/article/f4808f913077481ea8bc416f404cbbf7
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 11, Pp 985-995 (2024)
Abstract This study explored the mechanism by which the m6A demethylase ALKBH5 mediates epithelial–mesenchymal transition (EMT) in sepsis‐associated acute kidney injury (SA‐AKI) and AKI‐chronic kidney disease (CKD) transition. HK‐2 cells we
Externí odkaz:
https://doaj.org/article/d696954640b6402cbfdd67f0a43095c6
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Osteoporosis, a common bone disease in older individuals, involves the progression influenced by N6-methyladenosine (m6A) modification. This study aimed to elucidate the effects of VDAC3 m6A modification on human bone mesenchymal stromal cel
Externí odkaz:
https://doaj.org/article/99b9d8d7630e4689b706725e77995556
Autor:
Jianan Wang, Yuanyuan Ran, Zihan Li, Tianyuan Zhao, Fangfang Zhang, Juan Wang, Zongjian Liu, Xuechai Chen
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 3, Pp 887-899 (2025)
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin that causes Parkin
Externí odkaz:
https://doaj.org/article/3fc9e4e0783749c79e7d74ef72642f50
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 3, Pp 913-920 (2024)
Myeloid-derived suppressor cells (MDSCs) are closely related to the occurrence and development of many cancers, but the specific mechanism is not fully understood. It has been found that N6-methyladenosine (m6A) plays a key role in RNA metabolism, bu
Externí odkaz:
https://doaj.org/article/14c59d51407146d1823c6f866b2ddb7c
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract N6-methyladenosine (m6A) is dynamically regulated by methyltransferases (termed “writers”) and demethylases (referred to as “erasers”), facilitating a reversible modulation. Changes in m6A levels significantly influence cellular func
Externí odkaz:
https://doaj.org/article/5b7eca434a144816aca04265d217c2ae
Autor:
Weitong Shu, Qianying Huang, Rui Chen, Huatao Lan, Luxin Yu, Kai Cui, Wanjun He, Songshan Zhu, Mei Chen, Li Li, Dan Jiang, Guangxian Xu
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Gastrointestinal cancer is the most common malignancy in humans, often accompanied by poor prognosis. N6-methyladenosine (m6A) modification is widely present in eukaryotic cells as the most abundant RNA modification. It plays a crucial role
Externí odkaz:
https://doaj.org/article/27eef20b391e42cfaa8208d4d353bb94
Autor:
Kun Yang, Yongchao Zhao, Jingjing Hu, Rifeng Gao, Jiaran Shi, Xiang Wei, Juntao Chen, Kai Hu, Aijun Sun, Junbo Ge
Publikováno v:
Journal of Advanced Research, Vol 61, Iss , Pp 193-209 (2024)
Introduction: N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an m6A “eraser”, is responsible for decreased m6A modification. However, its role in cardiac f
Externí odkaz:
https://doaj.org/article/ffc8d5b420d1462da8c4d5ed1fbf2e5a
Publikováno v:
Biomolecules & Biomedicine (2024)
Acute myeloid leukemia (AML) is a fatal malignancy with rising incidence and low cure rates. This study aims to investigate the effect of ALKBH5-mediated m6A modification on adriamycin (ADR) resistance in AML. First, the levels of ALKBH5, TUG1, YTHDF
Externí odkaz:
https://doaj.org/article/8a88939019f94760855618d63a824e16
Publikováno v:
PeerJ, Vol 12, p e18227 (2024)
Background As one of the most common and abundant internal modifications of eukaryotic mRNA, N6-methyladenosine (m6A) modifications are closely related to placental development. Ferroptosis is a newly discovered form of programmed cell death. During
Externí odkaz:
https://doaj.org/article/f977bf36bb124dc8a54466ee33271fcd