Zobrazeno 1 - 10
of 233
pro vyhledávání: '"ALICIA J. KOWALTOWSKI"'
Autor:
Julio C. B. Ferreira, Juliane C. Campos, Nir Qvit, Xin Qi, Luiz H. M. Bozi, Luiz R. G. Bechara, Vanessa M. Lima, Bruno B. Queliconi, Marie-Helene Disatnik, Paulo M. M. Dourado, Alicia J. Kowaltowski, Daria Mochly-Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Externí odkaz:
https://doaj.org/article/4d5ed78c7bdb482089d69c8d01afb7e6
Autor:
Debora S. Rocha, Antonio C. Manucci, Alexandre Bruni-Cardoso, Alicia J. Kowaltowski, Eloisa A. Vilas-Boas
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101922- (2024)
Objective: Evaluation of mitochondrial oxygen consumption and ATP production is important to investigate pancreatic islet pathophysiology. Most studies use cell lines due to difficulties in measuring primary islet respiration, which requires specific
Externí odkaz:
https://doaj.org/article/1ed00cd0117949418d4b530eb6c90353
Autor:
Pamela A. Kakimoto, Julian David C. Serna, Vitor de Miranda Ramos, Antonio Zorzano, Alicia J. Kowaltowski
Publikováno v:
Redox Biology, Vol 45, Iss , Pp 102026- (2021)
Exposure to toxic levels of fatty acids (lipotoxicity) leads to cell damage and death and is involved in the pathogenesis of the metabolic syndrome. Since the metabolic consequences of lipotoxicity are still poorly understood, we studied the bioenerg
Externí odkaz:
https://doaj.org/article/d498b58d42ff4787b69de29d0b5d3d5c
Autor:
Julio C. B. Ferreira, Juliane C. Campos, Nir Qvit, Xin Qi, Luiz H. M. Bozi, Luiz R. G. Bechara, Vanessa M. Lima, Bruno B. Queliconi, Marie-Helene Disatnik, Paulo M. M. Dourado, Alicia J. Kowaltowski, Daria Mochly-Rosen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitof
Externí odkaz:
https://doaj.org/article/10da15e390414801950d6b6ca5915d4c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Steatosis is the accumulation of neutral lipids in the cytoplasm. In the liver, it is associated with overeating and a sedentary lifestyle, but may also be a result of xenobiotic toxicity and genetics. Non-alcoholic fatty liver disease (NAFLD) define
Externí odkaz:
https://doaj.org/article/5081729ba4fc44c2be63bc5b75087898
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 93, Iss 1 (2021)
Abstract Scientists are facing enormous pressures posed by growing scientific communities and stagnant/reduced funding. In this scenario, mechanisms of knowledge achievement and management, as well as how recruitment, progression and evaluation are c
Externí odkaz:
https://doaj.org/article/f1dd6fa58946403a829630d54f5816ce
Autor:
Fernanda M. Cerqueira, Sophia von Stockum, Marta Giacomello, Inna Goliand, Pamela Kakimoto, Elena Marchesan, Diego De Stefani, Alicia J. Kowaltowski, Elena Ziviani, Orian S. Shirihai
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101676- (2020)
UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenerg
Externí odkaz:
https://doaj.org/article/649dc9397584410ba185030c3121ac13
Autor:
Maria Fernanda Forni, Julia Peloggia, Tárcio T. Braga, Jesús Eduardo Ortega Chinchilla, Jorge Shinohara, Carlos Arturo Navas, Niels Olsen Saraiva Camara, Alicia J. Kowaltowski
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2678-2692 (2017)
Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its effect on the skin is poorly understood. Here, we show that CR mice display fur coat remodeling associated with an expansion of the hair follicle stem cell
Externí odkaz:
https://doaj.org/article/8684be283d9f456ebd386c8f55a28933
Autor:
Mateus P. Mori, Rute A. P. Costa, Daniela T. Soltys, Thiago de S. Freire, Franco A. Rossato, Ignácio Amigo, Alicia J. Kowaltowski, Aníbal E. Vercesi, Nadja C. de Souza-Pinto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Genomic instability drives tumorigenesis and DNA repair defects are associated with elevated cancer. Metabolic alterations are also observed during tumorigenesis, although a causal relationship between these has not been clearly established.
Externí odkaz:
https://doaj.org/article/8c3abd91e76c4e26a1355a84576051ac
Autor:
Alicia J. Kowaltowski
Publikováno v:
Redox Biology, Vol 21, Iss , Pp - (2019)
Mitochondrial oxidants (or reactive oxygen species) participate in a myriad of physiological and pathological processes. They are, however, quite hard to measure due to their chemical nature and specific subcellular location. Here, we review techniqu
Externí odkaz:
https://doaj.org/article/1783ab0f15634653a5a111526ff0334a