Zobrazeno 1 - 10
of 203
pro vyhledávání: '"ALICE M. CLARK"'
Autor:
Siddharth K. Tripathi, Qin Feng, Li Liu, David E. Levin, Kuldeep K. Roy, Robert J. Doerksen, Scott R. Baerson, Xiaomin Shi, Xuewen Pan, Wen-Hui Xu, Xing-Cong Li, Alice M. Clark, Ameeta K. Agarwal
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance. A promising strat
Externí odkaz:
https://doaj.org/article/5135f27089314ab884d2181bb1856ca4
Autor:
Alice M. Clark
Publikováno v:
Molecules, Vol 24, Iss 3, p 588 (2019)
This Special Issue is dedicated to the late Dr. Charles (Charlie) D. Hufford, former Professor of Pharmacognosy and Associate Dean for Research and Graduate Studies at the University of Mississippi [...]
Externí odkaz:
https://doaj.org/article/ceb3679961db4f9e89f93afeed57a044
Autor:
Ranga Rao Ravu, Shabana I. Khan, Xing-Cong Li, Alice M. Clark, Ameeta K. Agarwal, Melissa R. Jacob, Mei Wang, Liang Cao
Publikováno v:
Journal of natural products. 84(8)
The phloeodictine-based 6-hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium structural moiety with an n-tetradecyl side chain at C-6 has been demonstrated to be a new antifungal template. Thirty-four new synthetic analogues with modifications of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd12d3929ce58e3a3634e11fd96ed129
https://pubmed.ncbi.nlm.nih.gov/34283598
https://pubmed.ncbi.nlm.nih.gov/34283598
Autor:
Xuewen Pan, Siddharth K. Tripathi, David E. Levin, Ameeta K. Agarwal, Qin Feng, Xing-Cong Li, Scott R. Baerson, Kuldeep K. Roy, Li Liu, Wen-Hui Xu, Robert J. Doerksen, Xiaomin Shi, Alice M. Clark
Publikováno v:
mSphere
mSphere, Vol 5, Iss 1, p e00818-19 (2020)
mSphere, Vol 5, Iss 1 (2020)
mSphere, Vol 5, Iss 1, p e00818-19 (2020)
mSphere, Vol 5, Iss 1 (2020)
Fungal infections cause more fatalities worldwide each year than malaria or tuberculosis. Currently available antifungal drugs have various limitations, including host toxicity, narrow spectrum of activity, and pathogen resistance. Combining these dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569ef3e6221cff370a501e33683cf36c
https://pubmed.ncbi.nlm.nih.gov/31915228
https://pubmed.ncbi.nlm.nih.gov/31915228
Autor:
Alice M. Clark, Shabana Khan, Ameeta K. Agarwal, R. Kiplin Guy, Larry A. Walker, Xing-Cong Li, Melissa R. Jacob, Ying Tu, Ranga Rao Ravu, Cynthia Jeffries
Publikováno v:
Journal of Natural Products. 78:2255-2259
Antifungal screening of small-molecule natural product libraries showed that a column fraction (CF) derived from the plant extract of Sagittaria latifolia was active against the fungal pathogen Cryptococcus neoformans. Dereplication analysis by liqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bef47e1e1bd594f248cef3d39b4aee
https://doi.org/10.1021/acs.jnatprod.5b00470
https://doi.org/10.1021/acs.jnatprod.5b00470
Autor:
Ameeta K. Agarwal, Qin Feng, Siddharth K. Tripathi, Xing-Cong Li, Scott R. Baerson, Tao Xu, Melanie M. Mask, Michael C. Lorenz, Marsha A. Wright, Alice M. Clark, Melissa R. Jacob
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:2894-2907
6-Nonadecynoic acid (6-NDA), a plant-derived acetylenic acid, exhibits strong inhibitory activity against the human fungal pathogens Candida albicans , Aspergillus fumigatus , and Trichophyton mentagrophytes . In the present study, transcriptional pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8875b19b2efb0886762b4e39874b3943
https://doi.org/10.1128/aac.05663-11
https://doi.org/10.1128/aac.05663-11
Autor:
Xuewen Pan, Yongxiang Li, Ameeta K. Agarwal, Tao Xu, Zhiwei Huang, John D. Phillips, Kaifu Chen, Wei Li, Alice M. Clark, Jianhuai Zhang
Publikováno v:
Eukaryotic Cell. 10:1536-1544
The azaoxoaporphine alkaloid sampangine exhibits strong antiproliferation activity in various organisms. Previous studies suggested that it somehow affects heme metabolism and stimulates production of reactive oxygen species (ROS). In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603623df715c67cca3088457d8e42673
https://doi.org/10.1128/ec.05170-11
https://doi.org/10.1128/ec.05170-11
Publikováno v:
Journal of Natural Products. 74:2023-2026
Seven 6-alkyl-2,3,4,5-tetrahydropyridines (5a–5g) that mimic the natural piperideines that were recently identified in the fire ant venom have been synthesized. Compounds 5c–5g with the C-6 alkyl chain lengths from C14 to C18 showed varying degre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64319dcdf26511b302fbf5d572e1c2ef
https://doi.org/10.1021/np200644s
https://doi.org/10.1021/np200644s
Autor:
Mark T. Hamann, Bharathi Avula, Rabab Mohammed, Ameeta K. Agarwal, Qin Feng, Alice M. Clark, Siddharth K. Tripathi, Larry A. Walker, Scott R. Baerson, Melanie M. Mask, Tao Xu, Melissa R. Jacob, Ikhlas A. Khan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:1611-1621
Plakortide F acid (PFA), a marine-derived polyketide endoperoxide, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans , Cryptococcus neoformans , and Aspergillus fumigatus . In the present study, transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342023dfdfe24ee565d2b95554b06864
https://doi.org/10.1128/aac.01022-10
https://doi.org/10.1128/aac.01022-10
Autor:
Melissa R. Jacob, K. Suresh Babu, Ameeta K. Agarwal, Xing-Cong Li, Shabana I. Khan, Alice M. Clark
Publikováno v:
ACS Medicinal Chemistry Letters. 2:391-395
Synthetic analogues of the marine-derived class of natural products phloeodictines have been prepared and exhibited potent in vitro fungicidal activities against a broad array of fungal pathogens including drug resistant strains. The 6-hydroxy-2,3,4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fcd5a4018ea0907eb0b664882ea593
https://doi.org/10.1021/ml200020h
https://doi.org/10.1021/ml200020h