Anti-Viral Activities of Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Against Human Respiratory Viruses

Autor: Soo-Jin Oh, Eun-Na Lee, Joo-Hoo Park, Jae Kyung Lee, Geum Joon Cho, Il-Ho Park, Ok Sarah Shin

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

The endemic and pandemic caused by respiratory virus infection are a major cause of mortality and morbidity globally. Thus, broadly effective antiviral drugs are needed to treat respiratory viral diseases. Small extracellular vesicles derived from hu

Externí odkaz: https://doaj.org/article/16ef237566044f2f984ec486191332cc

Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials

Autor: Elisabeth Elje, Espen Mariussen, Erin McFadden, Maria Dusinska, Elise Rundén-Pran

Publikováno v: Nanomaterials, Vol 13, Iss 3, p 407 (2023)

For the next-generation risk assessment (NGRA) of chemicals and nanomaterials, new approach methodologies (NAMs) are needed for hazard assessment in compliance with the 3R’s to reduce, replace and refine animal experiments. This study aimed to esta

Externí odkaz: https://doaj.org/article/0416e4f50b98495fbc67f5447fba364e

Creating a More Perfect Union: Modeling Intestinal Bacteria-Epithelial Interactions Using Organoids

Autor: Joannie M. Allaire, Emily Davies, Bruce A. Vallance, Xiao Han, Matthias A. Mslati, Yan Chen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 769-782 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Intestinal organoids have become indispensable tools for many gastrointestinal researchers, advancing their studies of nontransformed intestinal epithelial cells, and their roles in an array of diseases, including inflammatory bowel disease and colon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfcd4164bf61b142a1794cbd355eae5
https://doi.org/10.1016/j.jcmgh.2021.04.010

Comparison of the basic morphology and function of 3D lung epithelial cultures derived from several donors

Autor: Julia Hoeng, David Bovard, Karsta Luettich, Albert Giralt, Stefan Frentzel, Athanasios Kondylis, Keyur Trivedi, Anita Iskandar, Laurent Neau, Petros Kanellos, Manuel C. Peitsch

Publikováno v: Current Research in Toxicology, Vol 1, Iss, Pp 56-69 (2020)
Current Research in Toxicology

In vitro models of the human lung play an essential role in evaluating the toxicity of inhaled compounds and understanding the development of respiratory diseases. Three-dimensional (3D) organotypic models derived from lung basal epithelial cells and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209f9d4739d978406cce3bbc04e2d3fb
https://doi.org/10.1016/j.crtox.2020.08.002

Iota-carrageenan extracted from red algae is a potent inhibitor of SARS‐CoV-2 infection in reconstituted human airway epithelia

Autor: David Bovard, Marco van der Toorn, Walter K. Schlage, Samuel Constant, Kasper Renggli, Manuel C. Peitsch, Julia Hoeng

Publikováno v: Biochemistry and Biophysics Reports, Vol 29, Iss, Pp 101187-(2022)
Biochemistry and Biophysics Reports

Iota-carrageenan (IC) nasal spray, a medical device approved for treating respiratory viral infections, has previously been shown to inhibit the ability of a variety of respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3ae8e543ea91b35ff4b83f91f2ed8c
http://www.sciencedirect.com/science/article/pii/S2405580821002818