Zobrazeno 1 - 10
of 62
pro vyhledávání: '"ALESSANDRA DALL'AGNESE"'
Autor:
Prasanna K.R. Allu, Maria Dafne Cardamone, Antonio S. Gomes, Alessandra Dall'agnese, Carly Cederquist, Hui Pan, Jonathan M. Dreyfuss, Sven Enerbäck, C. Ronald Kahn
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101825- (2023)
Objective: Insulin acts on the liver via changes in gene expression to maintain glucose and lipid homeostasis. This study aimed to the Forkhead box protein K1 (FOXK1) associated gene regulatory network as a transcriptional regulator of hepatic insuli
Externí odkaz:
https://doaj.org/article/d2e1cc8bad99432488ec8c7abd957cfd
Autor:
Alessandra Dall’Agnese, Jesse M. Platt, Ming M. Zheng, Max Friesen, Giuseppe Dall’Agnese, Alyssa M. Blaise, Jessica B. Spinelli, Jonathan E. Henninger, Erin N. Tevonian, Nancy M. Hannett, Charalampos Lazaris, Hannah K. Drescher, Lea M. Bartsch, Henry R. Kilgore, Rudolf Jaenisch, Linda G. Griffith, Ibrahim I. Cisse, Jacob F. Jeppesen, Tong I. Lee, Richard A. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.
Externí odkaz:
https://doaj.org/article/b6a27a393d354ad08dc4d2e2cdc0f034
Autor:
Marion Dejosez, Alessandra Dall’Agnese, Mahesh Ramamoorthy, Jesse Platt, Xing Yin, Megan Hogan, Ran Brosh, Abraham S. Weintraub, Denes Hnisz, Brian J. Abraham, Richard A. Young, Thomas P. Zwaka
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112505- (2023)
Summary: Genes that are key to cell identity are generally regulated by cell-type-specific enhancer elements bound by transcription factors, some of which facilitate looping to distant gene promoters. In contrast, genes that encode housekeeping funct
Externí odkaz:
https://doaj.org/article/8c6ebe16c9054ba39a8a57ba9441a0a9
Autor:
Paloma Cejas, Yingtian Xie, Alba Font-Tello, Klothilda Lim, Sudeepa Syamala, Xintao Qiu, Alok K. Tewari, Neel Shah, Holly M. Nguyen, Radhika A. Patel, Lisha Brown, Ilsa Coleman, Wenzel M. Hackeng, Lodewijk Brosens, Koen M. A. Dreijerink, Leigh Ellis, Sarah Abou Alaiwi, Ji-Heui Seo, Sylvan Baca, Himisha Beltran, Francesca Khani, Mark Pomerantz, Alessandra Dall’Agnese, Jett Crowdis, Eliezer M. Van Allen, Joaquim Bellmunt, Colm Morrisey, Peter S. Nelson, James DeCaprio, Anna Farago, Nicholas Dyson, Benjamin Drapkin, X. Shirley Liu, Matthew Freedman, Michael C. Haffner, Eva Corey, Myles Brown, Henry W. Long
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while dist
Externí odkaz:
https://doaj.org/article/049dc4c6a6fd4e8a9fc4ad8f4f885b4e
Autor:
David Sala, Thomas J. Cunningham, Michael J. Stec, Usue Etxaniz, Chiara Nicoletti, Alessandra Dall’Agnese, Pier Lorenzo Puri, Gregg Duester, Lucia Latella, Alessandra Sacco
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Induction of mitochondrial oxidative respiration is required for stem cell differentiation, but the mechanisms underlying this process are poorly understood. Here, the authors report that Stat3 promotes muscle stem cell differentiation by stimulating
Externí odkaz:
https://doaj.org/article/f73043aa60404babb39cc98df4240817
Autor:
Maria Clara Guida, Ryan Tyge Birse, Alessandra Dall’Agnese, Paula Coutinho Toto, Soda Balla Diop, Antonello Mai, Peter D. Adams, Pier Lorenzo Puri, Rolf Bodmer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Animal studies have shown that the nutritional status of parents can predispose the offspring to obesity and obesity-related diseases. Here the authors show that cardiac dysfunction induced by a high-fat diet persists for two generations in Drosophil
Externí odkaz:
https://doaj.org/article/85001e90453a42569a76b07b4ec8c15a
Autor:
Lavinia Bisceglie, Ann-Katrin Hopp, Kapila Gunasekera, Roni H. Wright, François Le Dily, Enrique Vidal, Alessandra Dall’Agnese, Luca Caputo, Chiara Nicoletti, Pier Lorenzo Puri, Miguel Beato, Michael O. Hottiger
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102432- (2021)
Summary: While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts to myoblasts prom
Externí odkaz:
https://doaj.org/article/7d19189afb6d4048bfbeb8b1940e2ea8
Autor:
Thomas C. Roberts, Usue Etxaniz, Alessandra Dall’Agnese, Shwu-Yuan Wu, Cheng-Ming Chiang, Paul E. Brennan, Matthew J. A. Wood, Pier Lorenzo Puri
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inh
Externí odkaz:
https://doaj.org/article/d950695199844891be7ec67ea14b2596
Autor:
Silvia Consalvi, Arianna Brancaccio, Alessandra Dall’Agnese, Pier Lorenzo Puri, Daniela Palacios
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
In skeletal muscle progenitors, EZH2 maintains myogenic genes in a repressed state, but during differentiation its levels are reduced via unknown mechanisms. Here the authors show that during myogenesis, p38α kinase phosphorylates EZH2 and targets i
Externí odkaz:
https://doaj.org/article/60dc0d431e904aa1aa98c1f73411a251
Autor:
Arup K. Chakraborty, John Mantiega, Anthony A. Hyman, Ann Boija, Mrityunjoy Kar, Patrick M. McCall, Jesse M. Platt, Charles H. Li, Mengyang Fan, Victoria E. Clark, Tong Lee, Alessandra Dall’Agnese, Jonathan E. Henninger, Krishna Shrinivas, Ido Sagi, Phillip A. Sharp, Dylan J. Taatjes, Tim-Michael Decker, Tinghu Zhang, Jing-Ke Weng, Eliot L. Coffey, Lena K. Afeyan, Alicia V. Zamudio, Nathanael S. Gray, Benjamin R. Sabari, Isaac A. Klein, Richard A. Young, Nancy M. Hannett, Young-Tae Chang, Ozgur Oksuz, Yang Guo, Susana Wilson Hawken
Publikováno v:
Cancer Research. 81:GS3-10
The molecules of the cell are compartmentalized into membrane- and non-membrane-bound organelles. Many non-membrane-bound organelles are phase-separated biomolecular condensates with distinct physicochemical properties that can absorb and concentrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::813421c57b00b902403b00605df75237
https://doi.org/10.1158/1538-7445.sabcs20-gs3-10
https://doi.org/10.1158/1538-7445.sabcs20-gs3-10