Recapitulating Cholangiopathy-Associated Necroptotic Cell Death In Vitro Using Human Cholangiocyte Organoids

Autor: Floris J.M. Roos, Qiuwei Pan, Petra E. de Ruiter, Jan N. M. IJzermans, Arif I. Ardisasmita, Henk P. Roest, Shaojun Shi, Monique M A Verstegen, Luc J. W. van der Laan, Marije Niemeijer, Wanlu Cao

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 541-564 (2022)
Cellular and Molecular Gastroenterology and Hepatology
CMGH, 13(2), 541-564. Elsevier Inc.

Background & Aims Liver and bile duct diseases often are associated with extensive cell death of cholangiocytes. Necroptosis represents a common mode of programmed cell death in cholangiopathy, however, detailed mechanistic knowledge is limited owing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd04ecf57291726ce9c8a99460e2895
https://doi.org/10.1016/j.jcmgh.2021.10.009

Viewpoint: 'Alcohol Consumption in Late Adolescence is Associated With an Increased Risk of Severe Liver Disease Later in Life'

Autor: Adriana Tamburello, Marco Marando, Stefano Bellentani

Publikováno v: Annals of Hepatology, Vol 17, Iss 3, Pp 343-344 (2018)

Drinking alcohol during adolescence predispose to severe liver disease in the adult phase. This is the main message of this prospective study. Each daily gram of alcohol men consumed in their youth was linked with a two percent increase in the risk o

Externí odkaz: https://doaj.org/article/1b3689f52ded4c969be2ea8963cdaf15

S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling

Autor: Pingping Luo, Rui Zhang, Qian Yu, George L. Tipoe, Ming Zheng, Xiaoming Sun, Yingxia Liu, Jia Xiao, Wei Li, Hong Zhang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 668-679 (2021)

Alcoholic liver disease (ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine (SAMC) from aged garlic on liver cell injury. A ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71348640a2921fa24860e2b42b33f51
http://europepmc.org/articles/PMC7982498

H2O2-mediated autophagy during ethanol metabolism

Autor: Sebastian Mueller, Shijin Wang, Vanessa Rausch, Linna Yu, Johannes Mueller, Cheng Chen, Franco Fortunato

Publikováno v: Redox Biology
Redox Biology, Vol 46, Iss, Pp 102081-(2021)

Background Alcoholic liver disease (ALD) is the most common liver disease worldwide and its underlying molecular mechanisms are still poorly understood. Moreover, conflicting data have been reported on potentially protective autophagy, the exact role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936d61c25a5f24c36b5bf0af348b8c2f
http://europepmc.org/articles/PMC8350071

Humoral Response to 2-dose BNT162b2 mRNA COVID-19 Vaccination in Liver Transplant Recipients

Autor: Maria Guarino, Ilaria Esposito, Giuseppe Portella, Valentina Cossiga, Ilaria Loperto, Raffaella Tortora, Michele Cennamo, Mario Capasso, Daniela Terracciano, Alfonso Galeota Lanza, Sarah Di Somma, Francesco Paolo Picciotto, Filomena Morisco, Giuseppina Pontillo, Luca Pignata, Maria Rosaria Attanasio, Raffaele Lieto, Francesco Cutolo, Marianna Cuomo

Publikováno v: Clinical Gastroenterology and Hepatology

In the context of the Italian severe acute respiratory syndrome coronavirus 2 vaccination program, liver transplant (LT) recipients were prioritized for vaccine administration, although the lower response to vaccines is a well-known problem in this p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba928e1a4ffffd1aec97614d96b822b0
https://doi.org/10.1016/j.cgh.2022.01.012