Zobrazeno 1 - 10
of 406
pro vyhledávání: '"ALBERT H. VAN GENNIP"'
Autor:
Rutger Meinsma, René Leen, Huib N. Caron, Albert H. van Gennip, André B.P. van Kuilenburg, Jörgen Bierau
Publikováno v:
Cancer chemotherapy and pharmacology, 57(1), 105-113. Springer Verlag
The effect of the CTP synthetase inhibitor cyclopentenyl cytosine (CPEC) on the metabolism and cytotoxicity of 2',2'-difluorodeoxycytidine (dFdC, gemcitabine) and the expression and activity of deoxycytidine kinase (dCK) was studied in human neurobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11320eb08bc6c44a181c5e4e4e247d6
https://doi.org/10.1007/s00280-005-0005-8
https://doi.org/10.1007/s00280-005-0005-8
Autor:
Ramon Martí, Michio Hirano, Jan J.G.M. Verschuuren, Alan L. Buchman, Ikuo Hirano, André B.P. van Kuilenburg, Saba Tadesse, Albert H. van Gennip, Ben J. H. M. Poorthuis
Publikováno v:
Annals of neurology, 58(4), 649-652. John Wiley and Sons Inc.
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in the gene encoding thymidine phosphorylase (TP). All MNGIE patients have had severe loss of TP function and prominent plasma accumulations of the TP substrates thy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f0cbe6c4e3040d70d9a8fa0799e574
https://doi.org/10.1002/ana.20615
https://doi.org/10.1002/ana.20615
Publikováno v:
Journal of Chromatography B. 805:339-346
A non-radioactive procedure to measure the deoxycytidine kinase (dCK) activity in crude cell free homogenates was developed. 2-Chlorodeoxyadenosine (CdA) was used as the substrate for dCK and was separated from its product 2-chlorodeoxyadenosine-5′
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::230425e00e4ff5328d5b5eba3c59119a
https://doi.org/10.1016/j.jchromb.2004.03.036
https://doi.org/10.1016/j.jchromb.2004.03.036
Publikováno v:
Obstetrics and Gynecology, 103(5), 876-880. LIPPINCOTT WILLIAMS & WILKINS
OBJECTIVE: Preeclampsia is associated with abnormal lipid metabolism, including fatty acid metabolism. Carnitine plays an indispensable role in the oxidation of fatty acids. The aim of the study was to evaluate the possible role of abnormal fatty add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2d21df0d0bb04a1ef9238fbc77d40f
https://doi.org/10.1097/01.aog.0000125699.60416.03
https://doi.org/10.1097/01.aog.0000125699.60416.03
Publikováno v:
The Plant Journal. 34:595-604
Summary In response to various environmental stress conditions, plants rapidly form the intracellular lipid second messenger phosphatidic acid (PA). It can be generated by two independent signalling pathways via phospholipase D (PLD) and via phosphol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d61e4766f79334213fe38f99742aad94
https://doi.org/10.1046/j.1365-313x.2003.01750.x
https://doi.org/10.1046/j.1365-313x.2003.01750.x
Autor:
Albert H. van Gennip, Annemieke J.M. de Ruijter, André B.P. van Kuilenburg, Huib N. Caron, Stephan Kemp
Publikováno v:
Biochemical Journal. 370:737-749
Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly influenced by the post-translational modification of histones, the building blocks of chromatin, such as methylation, phosphorylation and acetylation. Acetyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce1ab5bdc692f2215f26edfdf45307f
https://doi.org/10.1042/bj20021321
https://doi.org/10.1042/bj20021321
Autor:
Lia E.M van Lint, Stephan Kemp, Jacqueline J.M Selhorst, Albert H. van Gennip, Ronald J.A. Wanders, Fredoen Valianpour
Publikováno v:
Molecular genetics and metabolism, 79(3), 189-196. Academic Press Inc.
Elevated levels of very long-chain fatty acids (VLCFA) in plasma and tissues are the biochemical hallmark for patients with X-linked adrenoleukodystrophy (X-ALD). Current methods for the determination of VLCFA levels are laborious and time-consuming.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83db8235c243be2734030842bb5d624f
https://doi.org/10.1016/s1096-7192(03)00098-2
https://doi.org/10.1016/s1096-7192(03)00098-2
Autor:
André B.P. van Kuilenburg, Albert H. van Gennip, Jozien Helleman, Jörgen Bierau, René Leen, Huib N. Caron
Publikováno v:
International journal of cancer. Journal international du cancer, 103(3), 387-392. Wiley-Liss Inc.
CPEC is a potent inhibitor of CTP synthetase and causes depletion of CTP and dCTP pools. AraC is an analog of dCyd and a chemotherapeutic agent. Here, we demonstrate that, upon incubation with CPEC, both the anabolism and cytostatic effect of AraC in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22a3c555773a7e5a1484c2e6d460bc8
https://doi.org/10.1002/ijc.10858
https://doi.org/10.1002/ijc.10858
Publikováno v:
Annals of clinical biochemistry. 40(Part 1):41-45
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU). A deficiency of DPD is increasingly being recognized as the cause of an important pharmacogenetic syndrome. The importance of DPD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd462669c7c45242cc44339ad924582
https://doi.org/10.1258/000456303321016150
https://doi.org/10.1258/000456303321016150
Publikováno v:
Pharmacogenetics. 12:555-558
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU) and a DPD deficiency is increasingly being recognized as an important pharmacogenetic factor in the aetiology of severe 5FU-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b097b0729ad1d665ea5de986e0e14c
https://doi.org/10.1097/00008571-200210000-00007
https://doi.org/10.1097/00008571-200210000-00007