Zobrazeno 1 - 10
of 38
pro vyhledávání: '"ALAN M. EZRIN"'
Publikováno v:
Cell Stress Chaperones
As an extension of their orchestration of intracellular pathways, secretion of extracellular heat shock proteins (HSPs) is an emerging paradigm of homeostasis imperative to multicellular organization. Extracellular HSP is axiomatic to the survival of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddee44f65c271dce3dbbc376d62123b
https://pubmed.ncbi.nlm.nih.gov/33355877
https://pubmed.ncbi.nlm.nih.gov/33355877
Autor:
Michael A. Luther, Baha M. Sibai, Alan M. Ezrin, Michael R. Fannon, Keith Moore, Jackie Willmot, Sarah A Baxter, Brohman Brian D
Publikováno v:
American Journal of Perinatology. 32:605-614
Objective The purpose of this study was to determine whether the proteomic biosignature of circulating microparticles in maternal serum obtained in the second trimester could identify pregnancies that result in spontaneous preterm birth (SPTB). Study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da30e743743b56ddf67fa7e826807ffc
https://doi.org/10.1055/s-0035-1547322
https://doi.org/10.1055/s-0035-1547322
Publikováno v:
Journal of Cardiovascular Electrophysiology. 17:S71-S78
Late I Na Current Block Protects Against Proarrhythmia. Multiple components of cardiac Na current play a role in determining electrical excitation in the heart. Recently, the role of nonequilibrium components in controlling cardiac action potential p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf1f260b1dc4070543480353c593893
https://doi.org/10.1111/j.1540-8167.2006.00386.x
https://doi.org/10.1111/j.1540-8167.2006.00386.x
Autor:
Bertrand Plouvier, Peter M.R. Orth, Gregory N. Beatch, Alan M. Ezrin, Grace Jung, Janet Y.C. Chen, Shunping Lin, David Fedida
Publikováno v:
Journal of Cardiovascular Electrophysiology. 16:1227-1238
Introduction RSD1235 is a novel drug recently shown to convert AF rapidly and safely in patients.(1) Its mechanism of action has been investigated in a rat model of ischemic arrhythmia, along with changes in action potential (AP) morphology in isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cb3380f948776d2a8038af4718e617
https://doi.org/10.1111/j.1540-8167.2005.50028.x
https://doi.org/10.1111/j.1540-8167.2005.50028.x
Autor:
Denis Roy, Brian H. Rowe, Jacques S. Lee, John Ip, Denis C. Phaneuf, Ian G. Stiell, Sheila Grant, Benoit Coutu, Garth Dickinson, Humberto Vidaillet, Alan M. Ezrin, Gregory N. Beatch
Publikováno v:
Journal of the American College of Cardiology. 44:2355-2361
OBJECTIVES The purpose of this study was to determine the efficacy and safety of intravenous RSD1235 in terminating recent onset atrial fibrillation (AF). BACKGROUND Anti-arrhythmic drugs currently available to terminate AF have limited efficacy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f480db84be7e3e0470732a6384b8d53
https://doi.org/10.1016/j.jacc.2004.09.021
https://doi.org/10.1016/j.jacc.2004.09.021
Autor:
Robert E. Johnson, Paul J. Silver, Russell Becker, Nancy C. Birsner, Eric A. Bohnet, G. Maurice Briggs, Carl A. Busacca, Paul Canniff, Philip M. Carabateas, Thomas D'Ambra, Ronald L. Dundore, Jen-Sen Dung, Christopher C. Chadwick, Alan M. Ezrin, William Gorczyca, Peter G. Habeeb, Patrick Horan, Douglas S. Krafte, Gary Pelling, Bernard O'Connor, Manohar T. Saindane, Donald C. Schlegel, Gerald P. Stankus, John Swestock, Walter A. Volberg
Publikováno v:
Journal of Medicinal Chemistry. 38:2551-2556
A series of 4,5-dihydro-3-[2-(methanesulfonamidophenyl)ethyl]-1-phenyl- 1H-2,4-benzodiazepines has been identified as potential antiarrhythmic agents that interact at the delayed rectifier myocardial potassium channels (IKr) and prolong the ventricul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc92eadd0db68fb0531e2763844b686
https://doi.org/10.1021/jm00014a008
https://doi.org/10.1021/jm00014a008
Autor:
Kimberly G. Estep, Douglas S. Krafte, Nancy Dugrenier, Garry M. Pilling, Gerald P. Stankus, Philip M. Carabateas, Kurt A. Josef, Squire Rumney, Paul C. Canniff, William P. Gorczyca, Alan M. Ezrin, Bacon Edward R, G. Maurice Briggs, Kathleen Dillon, Walter A. Volberg
Publikováno v:
Journal of Medicinal Chemistry. 38:2582-2595
Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in Xenopus oocytes. Substances which remove or slow the Na channel inactivation process in car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46623797c69488b26414a46649968053
https://doi.org/10.1021/jm00014a011
https://doi.org/10.1021/jm00014a011
Autor:
Douglas S. Krafte, Christopher C. Chadwick, Bernard O'Connor, Alan M. Ezrin, Rober E. Johnson, Paul J. Silver, Walter A. Volberg
Publikováno v:
Drug Development Research. 34:376-380
We have previously shown that [3H]dofetilide binds with high affinity to sites associated with the guinea pig cardiac rapidly activating delayed rectifier K+ (IKr) channel and that class III antiarrhythmic agents, including dofetilide, clofilium, qui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad64fec8b63a8361f8bd1b44ebdd949a
https://doi.org/10.1002/ddr.430340410
https://doi.org/10.1002/ddr.430340410
Autor:
Thomas F. McElrath, Brohman Brian D, David E. Cantonwine, Kevin P. Rosenblatt, Alan M. Ezrin, Robert C. Doss, Gail Page, Zhen Zhang, Kevin S. Goudy
Publikováno v:
American Journal of Obstetrics and Gynecology. 214:631.e1-631.e11
The analysis of circulating microparticles in pregnancy is of revolutionary potential because it represents an in vivo biopsy of active gestational tissues.We hypothesized that circulating microparticle signaling will differ in pregnancies that exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce51ae7ccef78072c208258dc835d83c
https://doi.org/10.1016/j.ajog.2016.02.005
https://doi.org/10.1016/j.ajog.2016.02.005
Autor:
Paul J. Silver, Roland G. Kallen, Kimberly G. Estep, Douglas S. Krafte, Nancy Dugrenier, Kurt A. Josef, Kathleen Davison, Robert L. Barchi, Alan M. Ezrin
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 266:245-254
Pharmacological modulation of human sodium current was examined in Xenopus oocytes expressing human heart Na+ channels. Na+ currents activated near -50 mV with maximum current amplitudes observed at -20 mV. Steady-state inactivation was characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de686f0377d4aa04d9f3a64b1e789f76
https://doi.org/10.1016/0922-4106(94)90133-3
https://doi.org/10.1016/0922-4106(94)90133-3