The antagonism of prostaglandin FP receptors inhibits the evolution of spreading depolarization in an experimental model of global forebrain ischemia

Autor: Dániel P. Varga, Írisz Szabó, Viktória É. Varga, Ákos Menhyárt, Orsolya M. Tóth, Mihály Kozma, Armand R. Bálint, István A. Krizbai, Ferenc Bari, Eszter Farkas

Publikováno v: Neurobiology of Disease, Vol 137, Iss , Pp 104780- (2020)

Spontaneous, recurrent spreading depolarizations (SD) are increasingly more appreciated as a pathomechanism behind ischemic brain injuries. Although the prostaglandin F2α - FP receptor signaling pathway has been proposed to contribute to neurodegene

Externí odkaz: https://doaj.org/article/6efcf2d2c8764928b483f90266b17668

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Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury

Autor: Alexander V. Glushakov, Sylvain Doré, Connor L Bracy, Sean Robbins, Shuh Narumiya

Publikováno v: Journal of Neuroinflammation

Background Injuries to the brain promote upregulation of prostaglandins, notably the proinflammatory PGF2α, and overactivation of their cognate G-protein-coupled FP receptor, which could exacerbate neuronal damage. Our study is focused on investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de1db1961060f312ef4cb83aff52c2b

Prostaglandin F₂α modulates atrial chronotropic hyporesponsiveness to cholinergic stimulation in endotoxemic rats.

Autor: Nikoui V; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: nikoui@alumnus.tums.ac.ir., Ejtemaei Mehr S; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: ejtemam@tums.ac.ir., Jazaeri F; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: fjazaeri@yahoo.com., Ostadhadi S; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: ostadhadi@razi.tums.ac.ir., Eftekhari G; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: golnar.eftekhari@yahoo.com., Dehpour AR; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: dehpoura@sina.tums.ac.ir., Mani AR; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: mani@modares.ac.ir., Bakhtiarian A; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: bakhtiar@tums.ac.ir.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2015 Feb 05; Vol. 748, pp. 149-56. Date of Electronic Publication: 2014 Oct 18.