Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing.

Autor: Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR, Graff C, Öijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Gorno Tempini ML, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene DC, Lee-Way J, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, Van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.

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Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma

Autor: Carvalho, DM, Richardson, PJ, Olaciregui, N, Stankunaite, R, Lavarino, C, Molinari, V, Corley, EA, Smith, DP, Ruddle, R, Donovan, A, Pal, A, Raynaud, FI, Temelso, S, Mackay, A, Overington, JP, Phelan, A, Sheppard, D, Mackinnon, A, Zebian, B, Al-Sarraj, S, Merve, A, Pryce, J, Grill, J, Hubank, M, Cruz, O, Morales La Madrid, A, Mueller, S, Carcaboso, AM, Carceller, F, Jones, C

Publikováno v: CANCER DISCOVERY
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname

Somatic mutations in ACVR1 are found in a quarter of children with diffuse intrinsic pontine glioma (DIPG), but there are no ACVR1 inhibitors licensed for the disease. Using an artificial intelligence-based platform to search for approved compounds f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a356e26efbf88d83a9b4cddb0dbad753
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20115

MGMT Promoter Methylation: Prognostication beyond Treatment Response.

Autor: Ashkan K; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Baig Mirza A; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Soumpasis C; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Syrris C; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Kalaitzoglou D; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Sharma C; GKT School of Medicine, Kings College London, London SE1 1UL, UK., James ZJ; GKT School of Medicine, Kings College London, London SE1 1UL, UK., Khoja AK; GKT School of Medicine, Kings College London, London SE1 1UL, UK., Ahmed R; GKT School of Medicine, Kings College London, London SE1 1UL, UK., Vastani A; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Bartram J; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Chia K; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Al-Salihi O; Department of Neuro-Oncology, Cancer Centre, Guys Hospital, Great Maze Pond, London SE1 9RT, UK., Swampilai A; Department of Neuro-Oncology, Cancer Centre, Guys Hospital, Great Maze Pond, London SE1 9RT, UK., Brazil L; Department of Neuro-Oncology, Cancer Centre, Guys Hospital, Great Maze Pond, London SE1 9RT, UK., Laxton R; Department of Neuropathology, Kings College London, London SE5 9RS, UK., Reisz Z; Department of Neuropathology, Kings College London, London SE5 9RS, UK., Bodi I; Department of Neuropathology, Kings College London, London SE5 9RS, UK., King A; Department of Neuropathology, Kings College London, London SE5 9RS, UK., Gullan R; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Vergani F; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Bhangoo R; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Al-Sarraj S; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK., Lavrador JP; Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.

Publikováno v: Journal of personalized medicine [J Pers Med] 2023 Jun 14; Vol. 13 (6). Date of Electronic Publication: 2023 Jun 14.