Zobrazeno 1 - 10
of 703
pro vyhledávání: '"AKT/mTOR signaling"'
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 10255-10272 (2024)
Na Guo,1,* Yu Xia,1,* Nannan He,1 Huixin Cheng,1 Lei Zhang,2 Jian Liu1,2 1The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 2Gansu Provincial Maternity and Child-Care Hospital (G
Externí odkaz:
https://doaj.org/article/722842ef32bb4e67ac26948f00f8ecfb
Autor:
Chaoqun Wang, Yuntao Li, Yonggang Zhang, Daniel Smerin, Lijuan Gu, Shuting Jiang, Xiaoxing Xiong
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-19 (2024)
Abstract Background Triolein, a symmetric triglyceride exhibiting anti-inflammatory and antioxidant properties, has demonstrated potential in mitigating cellular damage. However, its therapeutic efficacy in ischemic stroke (IS) and underlying molecul
Externí odkaz:
https://doaj.org/article/2322faf789114aa99d5686c5ecf48b6b
Autor:
Kaiwen Zhang, Xingyu Zheng, Yiqing Sun, Xinyu Feng, Xirong Wu, Wenlu Liu, Chao Gao, Ye Yan, Wenyan Tian, Yingmei Wang
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTOvarian cancer (OC) is a form of gynecological malignancy that is associated with worse patient outcomes than any other cancer of the female reproductive tract. Topoisomerase II α (TOP2A) is commonly regarded as an oncogene that is associate
Externí odkaz:
https://doaj.org/article/f828b2d674374b2d8660d30302855606
Autor:
K. V. Nikulnikov, V. A. Bogdanova, L. V. Spirina, S. Yu. Chizhevskaya, I. V. Kondakova, E. L. Choynzonov, V. I. Chernov
Publikováno v:
Успехи молекулярной онкологии, Vol 11, Iss 1, Pp 46-54 (2024)
Introduction. Melanoma is the most dangerous neoplasm of the skin, characterized by a malignant and aggressive course. Transcriptional and growth factors, components of the AKT/mTOR signaling pathway, receptors and ligands of programmed cell death ar
Externí odkaz:
https://doaj.org/article/6b95f20c2dfc4abd81e7719a76815f51
Publikováno v:
Cancer Reports, Vol 7, Iss 9, Pp n/a-n/a (2024)
ABSTRACT Background Ewing’s sarcoma (ES) is the second most common malignant primary bone tumor in children and adolescents. Peroxiredoxin 2 (PRDX2) is an antioxidant enzyme. Aims Here, we investigated the role and mechanism of PRDX2 in the develop
Externí odkaz:
https://doaj.org/article/b3c6df59af9d47899ce09bea9b0b0029
Autor:
Liujing Qu, Yu Xin, Jieni Feng, Xiaolei Ren, Zuming Li, Xueru Chen, Guangyan Miao, Jiankun Chen, Chengming Sun, Yue Lu
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
PRKCI is abnormally expressed in various cancers, but its role in osteosarcoma is unknown. This study aimed to explore the biological function of PRKCI in osteosarcoma and its potential molecular mechanism. PRKCI expression was evaluated in osteosarc
Externí odkaz:
https://doaj.org/article/84b69291f7e2490ca32a26c40d88c331
Autor:
Xiwen Yang, Lei He, Xinyao Li, Lingling Wang, Tiao Bu, Damin Yun, Xinran Lu, Sheng Gao, Qiuru Huang, Jiaxin Li, Bo Zheng, Jun Yu, Fei Sun
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 279, Iss , Pp 116502- (2024)
Background: Despite the known reproductive toxicity induced by triptolide (TP) exposure, the regulatory mechanism underlying testicular vacuolization injury caused by TP remains largely obscure. Methods: Male mice were subjected to TP at doses of 15,
Externí odkaz:
https://doaj.org/article/a5fe9749042848d0833c1804f3e571d2
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Objective Investigating the impact of centromere protein N (CENP-N) on radiosensitivity of nasopharyngeal carcinoma (NPC) cells. Methods Using immunohistochemistry and immunofluorescence to detect CENP-N expression in tissues from 35 patient
Externí odkaz:
https://doaj.org/article/6868de2ba4444561856966d8b00cd57f
Publikováno v:
Cancer Medicine, Vol 12, Iss 14, Pp 15277-15288 (2023)
Abstract Background Umbelliprenin is a sesquiterpene coumarin isolated from Artemisia absinthium L. and shows antitumor effects in various cancers by inducing apoptosis. However, the antitumor effect of umbelliprenin in human pancreatic cancer has no
Externí odkaz:
https://doaj.org/article/d7aa006fdc834299bb7db395493347f4
Autor:
Guantong Sun, Xiaodong Li, Pengcheng Liu, Yao Wang, Cheng Yang, Shuhong Zhang, Lei Wang, Xiaoqing Wang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Osteoarthritis (OA) is the most prevalent degenerative joint disease, and PPARs are involved in its pathogenesis; however, the specific mechanisms by which changes in PPARδ impact the OA pathogenesis yet to be discovered. The purpose of this study w
Externí odkaz:
https://doaj.org/article/23479baa224242b3b65cc7e7e619a0a6