Zobrazeno 1 - 10
of 222
pro vyhledávání: '"AKIHIRO IKEDA"'
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32053- (2024)
With the recent expansion of structural variant identification in the human genome, understanding the role of these impactful variants in disease architecture is critically important. Currently, a large proportion of genome-wide-significant genome-wi
Externí odkaz:
https://doaj.org/article/7b69eb1475c1425d8d889d9bb6f2d8bd
Autor:
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an important regulator of the thermogenic capacity of brown adipocytes. Adipose-specific peroxisome deficiency impairs thermogenesis by inhibiting cold-ind
Externí odkaz:
https://doaj.org/article/42d6067bd5604ec8b3bf9b70db7ad1f8
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
Aging is the most significant risk factor for age-related diseases in general, which is true for age-related diseases in the eye including age-related macular degeneration (AMD). Therefore, in order to identify potential therapeutic targets for these
Externí odkaz:
https://doaj.org/article/88e6ae25510340a1bda227155eb5c0ac
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Autor:
Michael Landowski, Vijesh J. Bhute, Samuel Grindel, Zachary Haugstad, Yeboah K. Gyening, Madison Tytanic, Richard S. Brush, Lucas J. Moyer, David W. Nelson, Christopher R. Davis, Chi-Liang Eric Yen, Sakae Ikeda, Martin-Paul Agbaga, Akihiro Ikeda
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Lipid analysis of transmembrane protein 135 (TMEM135) mutant mice reveals robust decreases in docosahexaenoic acid (DHA), indicating a function of TMEM135 on the export of DHA from peroxisomes that is important for maintaining lipid metabolism.
Externí odkaz:
https://doaj.org/article/aac097ba34414892882b668cb0412247
Autor:
Hiroki Saito, Asami Tomita, Tomofumi Yoshida, Mitsuru Nakamura, Taro Suzuki, Akihiro Ikeda, Takahiro Kato, Yasunori Nakajima, Ryo Tanimoto, Toshio Tani, Nagao Hayashi, Hideyuki Hirabayashi, Ikuo Ando, Yoshimichi Fukuta
Publikováno v:
PhytoFrontiers, Vol 2, Iss 3, Pp 230-241 (2022)
Seven near isogenic lines (NILs) for six partial blast-resistance genes—Pi35, pi21, Pi37(t)(Pi37-KRIL17), Pb1, and Pi34 (two: Pi34-Chubu32 and Pi34-Chugoku40, originating from different Japonica Group rice lines, ‘Chubu 32’ and ‘Chugoku 40’
Externí odkaz:
https://doaj.org/article/3a2c3610467043a8843e468effd7ebaf
Autor:
Michael Landowski, Vijesh J. Bhute, Tetsuya Takimoto, Samuel Grindel, Pawan K. Shahi, Bikash R. Pattnaik, Sakae Ikeda, Akihiro Ikeda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Aging is a significant factor in the development of age-related diseases but how aging disrupts cellular homeostasis to cause age-related retinal disease is unknown. Here, we further our studies on transmembrane protein 135 (Tmem135), a gene
Externí odkaz:
https://doaj.org/article/d633aa25577040809a8ae0d6a88ae590
Publikováno v:
Journal of General and Family Medicine, Vol 23, Iss 4, Pp 289-290 (2022)
Externí odkaz:
https://doaj.org/article/96ecc0a1e6c143ed9e7c75a202e61474
Autor:
Nicholas J. Hess, Payton N. Lindner, Jessica Vazquez, Samuel Grindel, Amy W. Hudson, Aleksandar K. Stanic, Akihiro Ikeda, Peiman Hematti, Jenny E. Gumperz
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
NBSGW mice are highly immunodeficient and carry a hypomorphic mutation in the c-kit gene, providing a host environment that supports robust human hematopoietic expansion without pre-conditioning. These mice thus provide a model to investigate human h
Externí odkaz:
https://doaj.org/article/4c3bb1cca1d24553988c74833d7ba044
Autor:
Cornelius Mbathi Wainaina, Daigo Makihara, Mitsuru Nakamura, Akihiro Ikeda, Taro Suzuki, Yuko Mizukami, Toshihiro Nonoyama, Kazuyuki Doi, Mayumi Kikuta, Hiroaki Samejima, Daniel Makori Menge, Akira Yamauchi, Hidemi Kitano, John Munji Kimani, Yoshiaki Inukai
Publikováno v:
Plant Production Science, Vol 21, Iss 2, Pp 132-143 (2018)
In Africa, cold temperatures occur in the highlands of East and Southern Africa and in some areas of the Sahel region of West Africa leading to substantial rice yield losses. Cold tolerance (CT) at booting stage on basis of spikelet fertility after c
Externí odkaz:
https://doaj.org/article/8933704a6b174b6cac632bf3bd07c97b
Autor:
Nicole A. Muench, Sonia Patel, Margaret E. Maes, Ryan J. Donahue, Akihiro Ikeda, Robert W. Nickells
Publikováno v:
Cells, Vol 10, Iss 7, p 1593 (2021)
The important roles of mitochondrial function and dysfunction in the process of neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear to be a highly vulnerable neuronal cell type in the central nervous system with respect to
Externí odkaz:
https://doaj.org/article/881a629da11c4c40a617383655be56e0