Investigating tumoral and temporal heterogeneity through comprehensive -omics profiling in patients with metastatic triple negative breast cancer

Autor: Christopher Szeto, Rahul Parulkar, AJ Sedgewick, Stephen Charles Benz, Fabiola Cecchi, Todd A. Hembrough, Charles Joseph Vaske, Zack Sanborn, Shahrooz Rabizadeh, Elisabeth Mahen, Kimberly Burton, Patrick Soon-Shiong, Nicole Maria Kuderer, Francis Mark Senecal, Sibel Blau, C. Anthony Blau

Publikováno v: Journal of Clinical Oncology. 35:1093-1093

1093 Background: The “Intensive Trial of OMics in Cancer”-001 (ITOMIC-001; Clinicaltrials.gov ID: NCT01957514) enrolls patients with metastatic triple negative breast cancer (TNBC) who are platinum-naive and scheduled to receive cisplatin. Multip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::982668321b14429649b7dc26fa13e830
https://doi.org/10.1200/jco.2017.35.15_suppl.1093

Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort.

Autor: Leibowitz BD; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Dougherty BV; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Bell JSK; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Kapilivsky J; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Michuda J; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Sedgewick AJ; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Munson WA; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Chandra TA; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Dry JR; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Beaubier N; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Igartua C; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States., Taxter T; Tempus Labs, 600 W Chicago Ave Ste #510, Chicago, IL, 60654, United States. tim@tempus.com.

Publikováno v: BMC cancer [BMC Cancer] 2022 May 28; Vol. 22 (1), pp. 587. Date of Electronic Publication: 2022 May 28.

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.

Autor: Liu Y; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA.; Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, ShaanXi, China., Cook C; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Sedgewick AJ; ImmunityBio Inc, Culver City, CA, USA., Zhang S; Department of Physics, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA., Fassett MS; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Department of Immunology and Microbiology, University of California, San Francisco, San Francisco, CA, USA., Ricardo-Gonzalez RR; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Department of Immunology and Microbiology, University of California, San Francisco, San Francisco, CA, USA., Harirchian P; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Kashem SW; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA., Hanakawa S; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Leistico JR; Department of Physics, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA., North JP; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA., Taylor MA; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA., Zhang W; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Man MQ; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Charruyer A; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Beliakova-Bethell N; Department of Medicine, University of California San Diego, La Jolla, CA 92093-0679, USA.; Veterans Affairs Medical Center, San Diego, CA, USA., Benz SC; ImmunityBio Inc, Culver City, CA, USA., Ghadially R; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Mauro TM; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Kaplan DH; Departments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Kabashima K; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Singapore Immunology Network (SIgN) and Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore., Choi J; Department of Dermatology, Northwestern School of Medicine, Chicago, IL, USA., Song JS; Department of Physics, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA., Cho RJ; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA., Cheng JB; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Dermatology Service, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA.

Publikováno v: IScience [iScience] 2020 Sep 19; Vol. 23 (10), pp. 101582. Date of Electronic Publication: 2020 Sep 19 (Print Publication: 2020).

A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes.

Autor: Harirchian P; Department of Dermatology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California, USA., Lee J; Department of Dermatology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California, USA., Hilz S; Department of Neurological Surgery, University of California, San Francisco, California., Sedgewick AJ; Nantomics, LLC, Culver City, California., Perez White BE; Skin Tissue Engineering Core and Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Kesling MJ; Freelance Bioinformatician, San Francisco, California., Mully T; Department of Pathology, University of California, San Francisco, California., Golovato J; Nantomics, LLC, Culver City, California., Gray M; Nantomics, LLC, Culver City, California., Mauro TM; Department of Dermatology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California, USA., Purdom E; Department of Statistics, University of California, Berkeley, California., Kim EA; Department of Plastic Surgery, University of California, San Francisco, California., Sbitany H; Department of Plastic Surgery, University of California, San Francisco, California., Bhutani T; Department of Dermatology, University of California, San Francisco, California., Vaske CJ; Nantomics, LLC, Culver City, California., Benz SC; Nantomics, LLC, Culver City, California., Cho RJ; Department of Dermatology, University of California, San Francisco, California., Cheng JB; Department of Dermatology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California, USA. Electronic address: Jeffrey.cheng@ucsf.edu.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2019 Jun; Vol. 139 (6), pp. 1264-1273. Date of Electronic Publication: 2018 Dec 10.

PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy.

Autor: Abecassis I; Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Sedgewick AJ; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, Pennsylvania, USA., Romkes M; Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Buch S; Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Nukui T; Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Kapetanaki MG; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Vogt A; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Drug Discovery Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Kirkwood JM; Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Benos PV; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. benos@pitt.edu.; Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, Pennsylvania, USA. benos@pitt.edu., Tawbi H; Department of Melanoma Medical Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. HTawbi@mdanderson.org.; Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. HTawbi@mdanderson.org.

Publikováno v: Scientific reports [Sci Rep] 2019 Mar 01; Vol. 9 (1), pp. 3309. Date of Electronic Publication: 2019 Mar 01.