Zobrazeno 1 - 10
of 918
pro vyhledávání: '"AJ Lees"'
Autor:
LA Massey, MA Miranda, O Al-Helli, HG Parkes, JS Thornton, P-W So, MJ White, L Mancini, C Strand, J Holton, AJ Lees, T Revesz, TA Yousry
Publikováno v:
NeuroImage: Clinical, Vol 13, Iss C, Pp 154-163 (2017)
Background: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures. We sought to define the anatomy of the SN using high fie
Externí odkaz:
https://doaj.org/article/c1d4b16f92784e9db87b9f9c6b856453
Autor:
Debbie A Lawlor, N Wood, Philip C Haycock, Alastair J. Noyce, E Fernandez, Michael A. Nalls, A Schrag, John Hardy, Gibran Hemani, Patrick A. Lewis, Aude Nicolas, AB Singleton, Thomas Foltynie, Timothy Ryan Price, Demis A. Kia, Neil Pearce, AJ Lees, George Davey Smith
Publikováno v:
Movement Disorders. 32:S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d73d2f8f3962c5a0b8dab15d88208684
https://doi.org/10.1002/mds.26978
https://doi.org/10.1002/mds.26978
Autor:
A Sailer, Sarah J. Tabrizi, Zeshan Ahmed, Tamas Revesz, Janice L. Holton, AJ Lees, Henry Houlden, Abi Li
Publikováno v:
Neuropathology and Applied Neurobiology. 36:551-557
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f767333b339a7fa6c21a09d88753c96f
https://doi.org/10.1111/j.1365-2990.2010.01093.x
https://doi.org/10.1111/j.1365-2990.2010.01093.x
Autor:
Yan Xiang Yang, David S. Latchman, Nicholas W. Wood, James K.J. Diss, Miratul M. K. Muqit, Daniel G. Healy, Niall Quinn, Patrick M. A. Sleiman, Kailash P. Bhatia, Janice L. Holton, AJ Lees, Tamas Revesz, Mark R. Cookson, M. Van Der Brug
Publikováno v:
Neuroscience Letters. 457:75-79
Objective: We performed a mutation screen of NR4A2 (also known as NURR1) in 409 Parkinson's disease (PD) patients. We identified a novel single base substitution in the 5'UTR of the NR4A2 (also known as NURR1) gene (c.-309C > T). Results: We have per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a344d06296db26585a0808f71eb9ca
https://doi.org/10.1016/j.neulet.2009.03.021
https://doi.org/10.1016/j.neulet.2009.03.021
Publikováno v:
Neurology. 72:1677-1681
Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic failure (PAF) all present with varying degrees of dysautonomia and are pathologically characterized by accumulation of alpha-synuclein. Hyposmia and olfactory pathway pathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8aa8d42019c7f4ea6c68bc93f581e7
https://doi.org/10.1212/wnl.0b013e3181a55fd2
https://doi.org/10.1212/wnl.0b013e3181a55fd2
Autor:
AJ Lees, Aviva Petrie, Susanne A. Schneider, A. O'Donnell, Donald G. Grosset, Laura Silveira-Moriyama, Fátima Carrillo, Pablo Mir, Niall Quinn, Kailash P. Bhatia, Petra Schwingenschuh, Carmen Terranova
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 80:744-748
Positron emission tomography and single photon emission computed tomography scanning have 87-94% sensitivity and 80-100% specificity to differentiate patients with Parkinson's disease (PD) from control subjects and patients with essential (ET) or aty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c956bd7daa4838af1a5c0711a2e52e7
https://doi.org/10.1136/jnnp.2009.172825
https://doi.org/10.1136/jnnp.2009.172825
Autor:
Gregor K. Wenning, Nicholas W. Wood, David Robertson, Clare J. Fowler, Thomas Klockgether, David J. Brooks, Carlo Colosimo, Paola Sandroni, Marie Vidailhet, Niall Quinn, C. J. Mathias, Werner Poewe, AJ Lees, Phillip A. Low, Horacio Kaufmann, Sid Gilman, John Q. Trojanowski, Alexandra Durr, Tamas Revesz, Klaus Seppi
Publikováno v:
Gilman, S, Wenning, G K, Low, P A, Brooks, D J, Mathias, C J, Trojanowski, J Q, Wood, N W, Colosimo, C, Dürr, A, Fowler, C J, Kaufmann, H, Klockgether, T, Lees, A, Poewe, W, Quinn, N, Revesz, T, Robertson, D, Sandroni, P, Seppi, K & Vidailhet, M 2008, ' Second consensus statement on the diagnosis of multiple system atrophy ', Neurology, vol. 71, no. 9, pp. 670-676 . https://doi.org/10.1212/01.wnl.0000324625.00404.15
Background: A consensus conference on multiple system atrophy (MSA) in 1998 established criteria for diagnosis that have been accepted widely. Since then, clinical, laboratory, neuropathologic, and imaging studies have advanced the field, requiring a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e662759a5d3d6fc05cc693aa134422
https://doi.org/10.1212/01.wnl.0000324625.00404.15
https://doi.org/10.1212/01.wnl.0000324625.00404.15
Autor:
Jeremy Hobart, D. Ottaviani, Anette Schrag, Camille Carroll, AJ Lees, Alice J. Manson, Andrew Evans, R. Katzenschlager
Publikováno v:
Neurology. 69:555-563
Background: Drug-induced dyskinesias are a common and disabling clinical problem in the long-term management of Parkinson disease (PD). Their management and the development of new treatments rely on rigorous and meaningful dyskinesia measurement. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad1dc151823c442bd218c49372dc507
https://doi.org/10.1212/01.wnl.0000266669.18308.af
https://doi.org/10.1212/01.wnl.0000266669.18308.af
Publikováno v:
Movement Disorders. 21:989-996
Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are neurodegenerative disorders, each with a prevalence of around 5 per 100,000. Regional brain atrophy patterns differ in the two disorders, however, and magnetic resonance imagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05191a8ce0e9937508707638d0fe44dd
https://doi.org/10.1002/mds.20877
https://doi.org/10.1002/mds.20877