Zobrazeno 1 - 10
of 20
pro vyhledávání: '"AJ, adherens junction"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)
Background & Aims Epithelial cells form a monolayer at mucosal surface that functions as a highly selective barrier. Lysophosphatidic acid (LPA) is a bioactive lipid that elicits a broad range of biological effects via cognate G protein-coupled recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76070d2010df41333ad81cb10e8a8f40
http://europepmc.org/articles/PMC8350072
http://europepmc.org/articles/PMC8350072
Autor:
Sun Kyung Kim, Sabine Pokutta, Jonathon A. Heier, William I. Weis, Ian W. Dale, Andrew P. Hinck, Adam V. Kwiatkowski
Publikováno v:
The Journal of Biological Chemistry
α-Catenin binds directly to β-catenin and connects the cadherin–catenin complex to the actin cytoskeleton. Tension regulates α-catenin conformation. Actomyosin-generated force stretches the middle (M)-region to relieve autoinhibition and reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a700325b936258de9cb739688fcd0592
http://europepmc.org/articles/PMC8091058
http://europepmc.org/articles/PMC8091058
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1463-1482 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1463-1482 (2021)
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that continually shapes host pathophysiological responses. Despite readily available abundant metagenomic data, the functional dynamics of gut microbiota remain to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49158aad54b8f52d7f884de448f920a4
https://pubmed.ncbi.nlm.nih.gov/33610769
https://pubmed.ncbi.nlm.nih.gov/33610769
Autor:
Michael S. Donnenberg, Karen M. Scanlon, John J. Garber, Scott B. Snapper, Jerrold R. Turner, Emily M. Mallick, John M. Leong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 273-288 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 273-288 (2018)
Background & Aims Neural Wiskott-Aldrich Syndrome protein (N-WASP) is a key regulator of the actin cytoskeleton in epithelial tissues and is poised to mediate cytoskeletal-dependent aspects of apical junction complex (AJC) homeostasis. Attaching-and-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28760ed63e5fd5a3479481b0b279b85
https://doi.org/10.1016/j.jcmgh.2017.11.015
https://doi.org/10.1016/j.jcmgh.2017.11.015
Autor:
Loxham, Matthew, Davies, Donna E.
Publikováno v:
The Journal of Allergy and Clinical Immunology
The bronchial epithelium is continuously exposed to a multitude of noxious challenges in inhaled air. Cellular contact with most damaging agents is reduced by the action of the mucociliary apparatus and by formation of a physical barrier that control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2173200b3836170523819c9999e1f18
http://europepmc.org/articles/PMC5457128
http://europepmc.org/articles/PMC5457128
Autor:
Tingxi Yu, Myriam Gorospe, Suraj K. Jaladanki, Shaoyang Lan, Jian-Ying Wang, Hee K. Chung, Douglas J. Turner, Jun-Jie Piao, Jean-Pierre Raufman, Lan Xiao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 611-625 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 611-625 (2020)
Background & Aims The protective intestinal mucosal barrier consists of multiple elements including mucus and epithelial layers and immune defense; nonetheless, barrier dysfunction is common in various disorders. The imprinted and developmentally reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ce7e41f4c1e8e2210d6512117a5022
https://pubmed.ncbi.nlm.nih.gov/31862317
https://pubmed.ncbi.nlm.nih.gov/31862317
Autor:
Michaela Lang, Šárka Pospíšilová, Christoph Gasche, Melanie Borgmann, Boris Tichy, Maren Pflueger, Vineeta Khare, Harald Hundsberger, Alex Lyakhovich, Rayko Evstatiev, Gloria Luciani, Christoph Campregher, Kyle Dammann
Publikováno v:
Biochemical Pharmacology
Graphical abstract (a) PAK1 orchestrates mesalamine activity, (b) mesalamine inhibits PAK1; increases membranous E-cadherin and β-catenin; modulates cell adhesion
Mesalamine (5-ASA) is widely used for the treatment of ulcerative colitis, a remi
Mesalamine (5-ASA) is widely used for the treatment of ulcerative colitis, a remi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465876280c4cf2a6d3a046c05297a1de
Autor:
Ali, Shawki, Declan F, McCole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens. Inflammation pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34d53e9dab81e32fa8ec6c7b5e84db66
https://pubmed.ncbi.nlm.nih.gov/28174756
https://pubmed.ncbi.nlm.nih.gov/28174756
Autor:
Terry Lechler
Publikováno v:
Tissue Barriers
An exciting frontier in biology is understanding the functions of basic cell biological machinery in complex tissues. This approach is expected to uncover novel modes of regulation as well as reveal how core machinery is repurposed by different tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874dc7162b9c9bf48d7ca30fd17ace49
https://pubmed.ncbi.nlm.nih.gov/25610753
https://pubmed.ncbi.nlm.nih.gov/25610753
Autor:
Christoph Gasche, Kyle Dammann, Alex Lyakhovich, Vineeta Khare, Michaela Lang, Christoph Campregher
Publikováno v:
Biochemical Pharmacology
Graphical abstract 5-ASA induces membranous retention of E-cadherin through remodeling of N-glycans. Stabilization of E-cadherin at cell, contacts results in increased intercellular adhesion restricting tumor progression or restoring epithelial integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c36e47bd955990d110e5a04240bf2d