Actin polymerization and longitudinal actin fibers in axon initial segment plasticity

Autor: David Micinski, Pirta Hotulainen

Publikováno v: Frontiers in Molecular Neuroscience, Vol 17 (2024)

The location of the axon initial segment (AIS) at the junction between the soma and axon of neurons makes it instrumental in maintaining neural polarity and as the site for action potential generation. The AIS is also capable of large-scale relocatio

Externí odkaz: https://doaj.org/article/1b52bd2298284a81bcf0881447b9541a

Inhibition of AKT Signaling Alters βIV Spectrin Distribution at the AIS and Increases Neuronal Excitability

Autor: Jessica Di Re, Wei-Chun J. Hsu, Cihan B. Kayasandik, Nickolas Fularczyk, T. F. James, Miroslav N. Nenov, Pooran Negi, Mate Marosi, Federico Scala, Saurabh Prasad, Demetrio Labate, Fernanda Laezza

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

The axon initial segment (AIS) is a highly regulated subcellular domain required for neuronal firing. Changes in the AIS protein composition and distribution are a form of structural plasticity, which powerfully regulates neuronal activity and may un

Externí odkaz: https://doaj.org/article/c2065099e1604f758c3ff8744faa037f

Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study

Autor: Kumar, Sreedhar S., Gänswein, Tobias, Buccino, Alessio Paolo, Xue, Xiaohan, Bartram, Julian, Emmenegger, Vishalini, Hierlemann, Andreas

Publikováno v: Frontiers in Neuroinformatics, 16

Despite being composed of highly plastic neurons with extensive positive feedback, the nervous system maintains stable overall function. To keep activity within bounds, it relies on a set of negative feedback mechanisms that can induce stabilizing ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2763297c6fd893e361dbc295d049ac9e

Neuron Morphology Influences Axon Initial Segment Plasticity123

Autor: Gulledge, Allan T., Bravo, Jaime J.

Publikováno v: eNeuro

Visual Abstract
In most vertebrate neurons, action potentials are initiated in the axon initial segment (AIS), a specialized region of the axon containing a high density of voltage-gated sodium and potassium channels.
In most vertebrate neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8283b715592aee7a2b317b75151e6fdd
http://europepmc.org/articles/PMC4756267

Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice.

Autor: Thome C; Institute of Anatomy and Cell Biology, Johannes Kepler University, 4020 Linz, Austria.; Clinical Research Institute of Neuroscience, Johannes Kepler University, 4020 Linz, Austria.; Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany., Janssen JM; Institute of Anatomy and Cell Biology, Johannes Kepler University, 4020 Linz, Austria.; Clinical Research Institute of Neuroscience, Johannes Kepler University, 4020 Linz, Austria.; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Karabulut S; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Acuna C; Chica and Heinz Schaller Research Group, Institute of Anatomy and Cell Biology, Heidelberg University, 69120 Heidelberg, Germany., D'Este E; Optical Microscopy Facility, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany., Soyka SJ; Institute of Anatomy and Cell Biology, Dept. of Functional Neuroanatomy, Heidelberg University, 69120 Heidelberg, Germany., Baum K; Institute of Anatomy and Cell Biology, Johannes Kepler University, 4020 Linz, Austria.; Clinical Research Institute of Neuroscience, Johannes Kepler University, 4020 Linz, Austria., Bock M; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Lehmann N; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Roos J; Institute of Anatomy and Cell Biology, Johannes Kepler University, 4020 Linz, Austria.; Clinical Research Institute of Neuroscience, Johannes Kepler University, 4020 Linz, Austria.; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Stevens NA; Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany., Hasegawa M; German Center for Neurodegenerative Disease (DZNE), Neural Circuit Computations, 53127 Bonn, Germany., Ganea DA; University of Basel, Department of Biomedicine, 4031 Basel, Switzerland., Benoit CM; German Center for Neurodegenerative Disease (DZNE), Neural Circuit Computations, 53127 Bonn, Germany.; University of Basel, Department of Biomedicine, 4031 Basel, Switzerland., Gründemann J; German Center for Neurodegenerative Disease (DZNE), Neural Circuit Computations, 53127 Bonn, Germany.; University of Basel, Department of Biomedicine, 4031 Basel, Switzerland., Min L; Departments of Pharmacology and Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Bird KM; Departments of Pharmacology and Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Schultz C; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Bennett V; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Jenkins PM; Departments of Pharmacology and Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Engelhardt M; Institute of Anatomy and Cell Biology, Johannes Kepler University, 4020 Linz, Austria.; Clinical Research Institute of Neuroscience, Johannes Kepler University, 4020 Linz, Austria.; Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 19. Date of Electronic Publication: 2024 Jun 19.