Zobrazeno 1 - 10
of 43
pro vyhledávání: '"AIF, apoptosis inducing factor"'
Publikováno v:
Translational Oncology, Vol 17, Iss, Pp 101341-(2022)
Translational Oncology
Translational Oncology
Highlights • Thioredoxin reductase (TrxR), a seleno enzyme, regulates cellular redox. • Several human cancers are known to overexpress TrxR. • Inhibitors of TrxR have enhanced radiation induced cytotoxicity in multiple cancers. • TrxR could b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf62bdf3583fc4416746fca6cdfb01
http://www.sciencedirect.com/science/article/pii/S1936523322000031
http://www.sciencedirect.com/science/article/pii/S1936523322000031
Publikováno v:
Biochemistry and Biophysics Reports, Vol 27, Iss, Pp 101101-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Calpains are Ca2+-dependent cysteine proteases; their aberrant activation is associated with several neurodegenerative diseases. The μ-calpain catalytic subunit, calpain-1, is located in the cytoplasm as well as in the mitochondria. Mitochondrial ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcebec9e8dac6f6d8c60364ee995192
http://www.sciencedirect.com/science/article/pii/S2405580821001965
http://www.sciencedirect.com/science/article/pii/S2405580821001965
Autor:
Johannes Seeger, Marie Mewes, Sophie Sigusch, Aida Salameh, Ingo Dähnert, Marcel Vollroth, Stefan Dhein, Philipp Kiefer
Publikováno v:
Saudi Journal of Biological Sciences, Vol 27, Iss 1, Pp 18-29 (2020)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Severe inborn cardiac malformations are typically corrected in cardioplegia, with a cardio-pulmonary bypass (CPB) taking over body circulation. During the operation the arrested hearts are subjected to a global ischemia/reperfusion injury. Although t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5365bb8c01902b28b5ec20940c25b5
https://doi.org/10.1016/j.sjbs.2019.04.003
https://doi.org/10.1016/j.sjbs.2019.04.003
Autor:
Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303
https://pubmed.ncbi.nlm.nih.gov/35024303
Autor:
Akari Tanimichi, Jiro Kato, Takeshi Fujii, Arina Uno, Masato Mashimo, Sayaka Yamada, Xiangning Bu, Shigeru Negi, Noriko Sanada, Mana Mori, Joel Moss, Akari Nobeyama, Ryoichi Kizu, Mayu Onishi
Publikováno v:
The Journal of Biological Chemistry
Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear protein that is activated by binding to DNA lesions and catalyzes poly(ADP-ribosyl)ation of nuclear acceptor proteins, including PARP1 itself, to recruit DNA repair machinery to DNA lesions. When exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c1f8455c9c29620512fbb1ebd1351e
http://europepmc.org/articles/PMC7948984
http://europepmc.org/articles/PMC7948984
Publikováno v:
Pharmacological Research
Graphical abstract Molecular targets modulated by artemisinins in respiratory diseases.
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatm
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184b9b3d7b7767e97cb84ac3227c7da4
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 6, Pp 594-609 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. Despite progress in identifying risk factors, the incidence of HCC is increasing. Moreover, therapeutic options are limited and survival is poor. Therefore, alternative and inn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a9a0ec4a4cb12f3f5edd78c8d57e40
https://doi.org/10.1016/j.neo.2018.02.012
https://doi.org/10.1016/j.neo.2018.02.012
Autor:
Kim E. Barrett
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Adherent-invasive Escherichia coli are implicated in inflammatory bowel disease, and mitochondrial dysfunction has been observed in biopsy specimens from patients with inflammatory bowel disease. As a novel aspect of adherent-invasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93a2d7cc23500777e0bf52617aa3632
http://europepmc.org/articles/PMC7846483
http://europepmc.org/articles/PMC7846483
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 61-78 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 61-78 (2020)
Solute carrier (SLC) transporters meditate many essential physiological functions, including nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and infections, the mammalian immune system coordinates complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5e0fa191bfe0e2b3ae38f78a7e5b59
https://pubmed.ncbi.nlm.nih.gov/31993307
https://pubmed.ncbi.nlm.nih.gov/31993307
Publikováno v:
Redox Biology
Redox Biology, Vol 11, Iss, Pp 592-599 (2017)
Redox Biology, Vol 11, Iss, Pp 592-599 (2017)
N-acetyl serotonin (NAS) as a melatonin precursor has neuroprotective actions. Nonetheless, it is not clarified how NAS protects neuronal cells against oxidative stress. Recently, we have reported that N-palmitoyl serotonins possessed properties of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5666541f328d5af707133ed7df75f1bc
http://europepmc.org/articles/PMC5247570
http://europepmc.org/articles/PMC5247570