Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Autor: Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M. Chakrabarti, Andrew M. Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R. Sibley, Aida Martinez-Sanchez, Boris Lenhard

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-23 (2024)

Abstract The 3′ untranslated region (3′UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a method for the detection of capped 5′ ends of mRNAs, additional

Externí odkaz: https://doaj.org/article/ad037dcdd70a4cf1aefd83bb7b5773ce

Molecular Mechanisms of Nutrient-Mediated Regulation of MicroRNAs in Pancreatic β-cells

Autor: Anna Sałówka, Aida Martinez-Sanchez

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Pancreatic β-cells within the islets of Langerhans respond to rising blood glucose levels by secreting insulin that stimulates glucose uptake by peripheral tissues to maintain whole body energy homeostasis. To different extents, failure of β-cell f

Externí odkaz: https://doaj.org/article/72ee82b219284ae1a16e8d2b951e5da0

MicroRNA Target Identification—Experimental Approaches

Autor: Aida Martinez-Sanchez, Chris L. Murphy

Publikováno v: Biology, Vol 2, Iss 1, Pp 189-205 (2013)

MicroRNAs (miRNAs) are small non-coding RNA molecules of 21–23 nucleotides that control gene expression at the post-transcriptional level. They have been shown to play a vital role in a wide variety of biological processes and dysregulated expressi

Externí odkaz: https://doaj.org/article/c2862478a0d74d8fb6ffbd764c776c43

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

Autor: Marie-Sophie Nguyen-Tu, Joseph Harris, Aida Martinez-Sanchez, Pauline Chabosseau, Ming Hu, Eleni Georgiadou, Alice Pollard, Pablo Otero, Livia Lopez-Noriega, Isabelle Leclerc, Kei Sakamoto, Dieter Schmoll, David M. Smith, David Carling, Guy A. Rutter

Publikováno v: Nguyen-Tu, M-S, Harris, J, Martinez-Sanchez, A, Chabosseau, P, Hu, M, Georgiadou, E, Pollard, A, Otero, P, Lopez-Noriega, L, Leclerc, I, Sakamoto, K, Schmoll, D, Smith, D M, Carling, D & Rutter, G A 2022, ' Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase ', Diabetologia, vol. 65, pp. 997-1011 . https://doi.org/10.1007/s00125-022-05673-x

Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6227421373a23cecf46c480007056b6b
https://doi.org/10.1007/s00125-022-05673-x

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

Autor: Alex Montoya, Emirhan Tasoez, Holger Kramer, Olof Idevall-Hagren, S Neda Mousavy Gharavy, Steven Millership, Mark Ibberson, Ming Hu, Aida Martinez-Sanchez, Paul Gadue, Eleni Georgiadou, Isabelle Leclerc, Dominic J. Withers, Nikolay Ninov, Bryn M. Owen, Pauline Chabosseau, Grazia Pizza, David A. Jacobson, Matthew T. Dickerson, Fabian L. Cardenas-Diaz, Zenobia B. Mehta, Marianne Voz, Christophe Magnan, Céline Cruciani-Guglielmacci, Nicholas H. F. Fine, Guy A. Rutter

Publikováno v: Diabetologia
Diabetologia, 2021, 64 (4), pp.850-864. ⟨10.1007/s00125-020-05350-x⟩

Aims/hypothesis Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3515d1e5f62db8cf8036e2aa24a6876b
http://europepmc.org/articles/PMC7829492