Zobrazeno 1 - 7
of 7
pro vyhledávání: '"AGUSTIN A. GIL SILVA"'
Autor:
Angela M. Hinchie, Samantha L. Sanford, Kelly E. Loughridge, Rachel M. Sutton, Anishka H. Parikh, Agustin A. Gil Silva, Daniel I. Sullivan, Pattra Chun-On, Matthew R. Morrell, John F. McDyer, Patricia L. Opresko, Jonathan K. Alder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The telomere sequence, TTAGGG, is conserved across all vertebrates and plays an essential role in suppressing the DNA damage response by binding a set of proteins termed shelterin. Changes in the telomere sequence impair shelterin binding, i
Externí odkaz:
https://doaj.org/article/1d8229a837ff47dab3abeb379196b575
Autor:
Timmy Strauss, Julia Körholz, Hye Sun Kuehn, Agustin A. Gil Silva, Franziska Taube, Karolin Trautmann-Grill, Anna Stittrich, Leonora Pietzsch, Ralf Wiedemuth, Volker Wahn, Horst von Bernuth, Sergio D. Rosenzweig, Maria Fasshauer, Renate Krüger, Catharina Schuetz
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Heterozygous germline variants in human IKZF1 encoding for IKAROS define an inborn error of immunity with immunodeficiency, immune dysregulation and risk of malignancy with a broad phenotypic spectrum. Growing evidence of underlying pathophysiologica
Externí odkaz:
https://doaj.org/article/3e8835010a834401813ac42077f21c6e
Autor:
Guifang Wang, Che Xu, Zongmei Wen, Joseph M. Pilewski, Jonathan K. Alder, Agustin Alejandro Gil Silva, John F. McDyer, X. Wang, Junyi Yu, Pablo G. Sanchez, Janet S. Lee
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 321:L653-L662
Uncontrolled donation after cardiac death (uDCD) contributes little to ameliorating donor lung shortage due to rapidly progressive warm ischemia after circulatory arrest. Here, we demonstrated that nonhypoxia improves donor lung viability in a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28591a975922834754b8c9feda55eea4
https://doi.org/10.1152/ajplung.00011.2021
https://doi.org/10.1152/ajplung.00011.2021
Autor:
Pattra Chun-on, Angela M. Hinchie, Holly C. Beale, Agustin A Gil Silva, Elizabeth Rush, Cindy Sander, Carla J. Connelly, Brittani K.N. Seynnaeve, John M. Kirkwood, Olena M. Vaske, Carol W. Greider, Jonathan K. Alder
Publikováno v:
Science (New York, N.Y.). 378(6620)
Overcoming replicative senescence is an essential step during oncogenesis, and the reactivation of TERT through promoter mutations is a common mechanism. TERT promoter mutations are acquired in about 75% of melanomas but are not sufficient to maintai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f3a42bccab9b89e2b0637b2a386a7d
https://pubmed.ncbi.nlm.nih.gov/36356143
https://pubmed.ncbi.nlm.nih.gov/36356143
Autor:
JEFFREY CHEN, FIONA BELLO, JAKE KASTROLL, AMBER VANDEVENDER, MARTHA PANGBURN, AGUSTIN A. GIL SILVA, IAN J. SIPULA, JONATHAN ALDER, MICHAEL J. JURCZAK
Publikováno v:
Diabetes. 71
Growth differentiation factor 15 (GDF15) is a secreted protein whose cellular expression increases in response to a variety of stimuli, including mitochondrial dysfunction. Plasma GDF15 levels increase with advanced age and positively associate with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f6d6904e76fde01482813129a162c8f
https://doi.org/10.2337/db22-1368-p
https://doi.org/10.2337/db22-1368-p
Autor:
BINGXIAN XIE, ANJANA MURALI, AMBER VANDEVENDER, AGUSTIN A. GIL SILVA, FIONA BELLO, IAN J. SIPULA, NIKOLAOS DEDOUSIS, JONATHAN ALDER, MICHAEL J. JURCZAK
Publikováno v:
Diabetes. 71
Growth and differentiation factor 15 (GDF15) is a stress-induced secreted protein whose plasma levels are increased in obese patients. Recombinant GDF15 reduces body weight (BW) and improves glycemia in obese models, which is largely attributed to ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab03e85155f2fdf1ed14d31bcdf195c
https://doi.org/10.2337/db22-3-or
https://doi.org/10.2337/db22-3-or
Autor:
Junyi Yu, Che Xu, Zongmei Wen, Guifang Wang, Agustin Alejandro Gil Silva, Mark J. Brown, Pablo G. Sanchez, Xingan Wang
Publikováno v:
The Journal of thoracic and cardiovascular surgery.
Hypotension episodes before or after donor brain death are assumed to trigger hypoxia-reoxygenation, causing diffuse alveolar-capillary damage via necrosis. However, alveolar-capillary membranes have direct access to oxygen in alveoli. We hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1867ffe5e31814a444f077b9f8407c13
https://pubmed.ncbi.nlm.nih.gov/35850733
https://pubmed.ncbi.nlm.nih.gov/35850733