Zobrazeno 1 - 10
of 16
pro vyhledávání: '"AGT, angiotensinogen"'
Autor:
Kaixuan Yan, Yong Yang, Shuang Hua, Ying Xu, Xue Jiang, Jufei Li, Xianglu Rong, Danqi Zou, Dewei Ye
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss, Pp 111685-(2021)
Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy
Type 2 diabetes mellitus, obesity, hypertension, and other associated metabolic complications have been demonstrated as a crucial contributor to the enhanced morbidity and mortality of patients with coronavirus disease 2019 (COVID-19). Data on the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03997d986ad803566f507d23d3831d1d
http://www.sciencedirect.com/science/article/pii/S0753332221004674
http://www.sciencedirect.com/science/article/pii/S0753332221004674
Publikováno v:
Journal of Medicine and Life
There is an increasing number of studies suggesting the role of genetic factors in the development and progression of chronic obstructive pulmonary disease and hypertension. Therefore, our study aimed to establish the role of ACE and AGT gene polymor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd255abba84e50e5adddf62ef149ab7d
https://doi.org/10.25122/jml-2019-0108
https://doi.org/10.25122/jml-2019-0108
Autor:
Yvonne Tami, Erin S. Morgan, George L. Bakris, Richard S. Geary, Adam E. Mullick, Kuolung Hu, Michela Brambatti, Sotirios Tsimikas
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Targeting AGT is a novel approach to inhibit the RAAS pathway. • AGT is primarily synthesized in the liver. • IONIS-AGT-LRx is an ASO directed to hepatocyte-derived AGT. • In 2 phase 2 trials as monotherapy a
Highlights • Targeting AGT is a novel approach to inhibit the RAAS pathway. • AGT is primarily synthesized in the liver. • IONIS-AGT-LRx is an ASO directed to hepatocyte-derived AGT. • In 2 phase 2 trials as monotherapy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e616d76b659e1de4ea238019d64e1e
https://pubmed.ncbi.nlm.nih.gov/34040182
https://pubmed.ncbi.nlm.nih.gov/34040182
Publikováno v:
The Journal of Biological Chemistry
Oncogenic K-Ras (K-RasG12V) promotes senescence in normal cells but fuels transformation of cancer cells after the senescence barrier is bypassed. The mechanisms regulating this pleiotropic function of K-Ras remain to be fully established and bear hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19fb7ad3c03a7d04869972588b6b596
http://europepmc.org/articles/PMC7948762
http://europepmc.org/articles/PMC7948762
Publikováno v:
Biochimie
Biochimie, Elsevier, 2020, ⟨10.1016/j.biochi.2020.07.001⟩
Biochimie, Elsevier, 2020, ⟨10.1016/j.biochi.2020.07.001⟩
It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3e5cffb791eb1393f0ccc6eb1dcfd3
https://hal.archives-ouvertes.fr/hal-02902650
https://hal.archives-ouvertes.fr/hal-02902650
Publikováno v:
Asian Journal of Psychiatry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddd44a7c2db2dea8b363dbdd91498c3
https://doi.org/10.1016/j.ajp.2021.102981
https://doi.org/10.1016/j.ajp.2021.102981
Autor:
Jeffrey A. Welge, Carri R. Warshak, Janet M. Catov, Debi K. Swertfeger, Scott E. Street, Jamie Morris, John T. Melchior, Laura A. Woollett, Alan T. Remaley, W. Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100107-(2021)
Journal of Lipid Research
Journal of Lipid Research
Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on the generic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0c9bc0d92147958dbe68c94eb42b3f
https://doi.org/10.1016/j.jlr.2021.100107
https://doi.org/10.1016/j.jlr.2021.100107
Publikováno v:
Archives of Cardiovascular Diseases
Summary The discovery of angiotensin-I-converting enzyme 2 (ACE2) and a (pro)renin receptor has renewed interest in the physiology of the renin-angiotensin system (RAS). Through the ACE2/angiotensin-(1–7)/Mas counter-regulatory axis, ACE2 balances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc261142323704b99c37791272ffd43
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