Zobrazeno 1 - 10
of 16
pro vyhledávání: '"AGATA P. PERLINSKA"'
Autor:
Agata P. Perlinska, Mai Lan Nguyen, Smita P. Pilla, Emilia Staszor, Iwona Lewandowska, Agata Bernat, Elżbieta Purta, Rafal Augustyniak, Janusz M. Bujnicki, Joanna I. Sulkowska
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
We have been aware of the existence of knotted proteins for over 30 years—but it is hard to predict what is the most complicated knot that can be formed in proteins. Here, we show new and the most complex knotted topologies recorded to date—doubl
Externí odkaz:
https://doaj.org/article/00796d098d6c4af09d78c454d2c03937
Autor:
Mateusz Jedrzejewski, Barbara Belza, Iwona Lewandowska, Marta Sadlej, Agata P. Perlinska, Rafal Augustyniak, Thomas Christian, Ya-Ming Hou, Marcin Kalek, Joanna I. Sulkowska
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3999-4008 (2023)
The Nep1 protein is essential for the formation of eukaryotic and archaeal small ribosomal subunits, and it catalyzes the site-directed SAM-dependent methylation of pseudouridine (Ψ) during pre-rRNA processing. It possesses a non–trivial topology,
Externí odkaz:
https://doaj.org/article/fce9cd31689d48fc924328112827005f
MOLECULAR DYNAMICS AND STRUCTURAL COMPARISON APPROACH TO UNDERSTANDING THE ROLE OF KNOTS IN PROTEINS
Publikováno v:
TASK Quarterly, Vol 20, Iss 4 (2016)
The role of knots in proteins is still unclear. In this short review, we summarize the current knowledge about structural and dynamical differences between knotted and unknotted proteins. We show how the topological difference helps to distinguish th
Externí odkaz:
https://doaj.org/article/f3a24effe59f4625b9e8497565a9f48b
Autor:
Agata P. Perlinska, Wanda H. Niemyska, Bartosz A. Gren, Marek Bukowicki, Szymon Nowakowski, Pawel Rubach, Joanna I. Sulkowska
Publikováno v:
Protein Science. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f4a3d275587c112eaa6b8807c76c23
https://doi.org/10.1002/pro.4631
https://doi.org/10.1002/pro.4631
Autor:
Mateusz Jedrzejewski, Barbara Bełza, Iwona Lewandowska, Marta Sadlej, Agata P. Perlinska, Rafal Augustyniak, Thomas Christian, Ya–Ming Hou, Marcin Kalek, Joanna I. Sulkowska
Nep1 is a protein essential for the formation of the eukaryotic and archaeal small ribosomal subunit. It is an enzyme responsible for the site–specific SAM–dependent methylation of pseudouridine (Ψ) during the pre–rRNA processing. It possesses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb073b8947141a7919c8efbb36f3765
https://doi.org/10.1101/2023.03.21.532383
https://doi.org/10.1101/2023.03.21.532383
Autor:
Agata P. Perlinska, Adam Stasiulewicz, Mai Lan Nguyen, Karolina Swiderska, Mikolaj Zmudzinski, Alicja W. Maksymiuk, Marcin Drag, Joanna I. Sulkowska
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused both a health and economic crisis around the world. Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs that would aid vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f540ea164e5fe30d636283d3104c75f
https://www.repository.cam.ac.uk/handle/1810/344727
https://www.repository.cam.ac.uk/handle/1810/344727
Publikováno v:
ACS Catalysis. 10:8058-8068
Mg2+ is required for the catalytic activity of TrmD, a bacteria-specific methyltransferase that is made up of a protein topological knot-fold, to synthesize methylated m1G37-tRNA to support life. H...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ae957001bbbffa3785f4ada4cf71a5
https://doi.org/10.1021/acscatal.0c00059
https://doi.org/10.1021/acscatal.0c00059
Autor:
Aleksandra I. Jarmolinska, Vasilina Zayats, Agata P. Perlinska, Borys Jastrzebski, Stanislaw Dunin-Horkawicz, Joanna I. Sulkowska
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009502 (2021)
PLoS Computational Biology
PLoS Computational Biology
While the slipknot topology in proteins has been known for over a decade, its evolutionary origin is still a mystery. We have identified a previously overlooked slipknot motif in a family of two-domain membrane transporters. Moreover, we found that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe123765b5ef20f32571ee741a7b5a6d
https://doaj.org/article/f105ce84f84c4826ad5083eca7f3d2ec
https://doaj.org/article/f105ce84f84c4826ad5083eca7f3d2ec
Autor:
Helen M. Ginn, Peter Virnau, Benjamin Trefz, Aleksandra I. Jarmolinska, Robert Runkel, Agata P. Perlinska, Joanna I. Sulkowska
Publikováno v:
Journal of Molecular Biology. 431:244-257
Knots in proteins are increasingly being recognized as an important structural concept, and the folding of these peculiar structures still poses considerable challenges. From a functional point of view, most protein knots discovered so far are either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b0fc6e687825801c6adbf26946fc76
https://doi.org/10.1016/j.jmb.2018.10.012
https://doi.org/10.1016/j.jmb.2018.10.012
Publikováno v:
ACS Catalysis
Mg2+ is required for the catalytic activity of TrmD, a bacteria-specific methyltransferase that is made up of a protein topological knot-fold, to synthesize methylated m1G37-tRNA to support life. However, neither the location of Mg2+ in the structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a2233ddbeb58b0d2503c32c977ba808
https://pubmed.ncbi.nlm.nih.gov/32904895
https://pubmed.ncbi.nlm.nih.gov/32904895