Zobrazeno 1 - 10
of 273
pro vyhledávání: '"AF-2"'
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-10 (2023)
Abstract Background Carcinogenic risk assessment studies have been repeatedly improved and are still being debated to find a goal. Evaluation might be changed if new approaches would be applied to some chemicals which means that new approaches may ch
Externí odkaz:
https://doaj.org/article/b42c2d763fe24571991782f598b59fc7
Akademický článek
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Publikováno v:
Cells, Vol 11, Iss 19, p 2974 (2022)
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with high levels of expression in the liver. It not only plays a key role in drug metabolism and elimination, but also promotes tumor growth, drug resistance, and met
Externí odkaz:
https://doaj.org/article/de607d68ad2e43dbb50e089162525b94
Akademický článek
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Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 6, Iss, Pp 544-549 (2019)
Toxicology Reports, Vol 6, Iss, Pp 544-549 (2019)
Highlights • Kaempferia parviflora extract exhibited no genotoxicity. • The no-observed-adverse-effect-level (NOAEL) of the extract was > 249 mg/kg. • Our results indicate that Kaempferia parviflora extract has a high degree of safety.
Kae
Kae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071960324b207e4225268f0842d97610
https://doi.org/10.1016/j.toxrep.2019.06.003
https://doi.org/10.1016/j.toxrep.2019.06.003
Publikováno v:
The Journal of Biological Chemistry
Nuclear receptors (NRs) activate transcription of target genes in response to binding of ligands to their ligand-binding domains (LBDs). Typically, in vitro assays use either gene expression or the recruitment of coactivators to the isolated LBD of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a651259b1d286bcaadc32e55691b956
https://pubmed.ncbi.nlm.nih.gov/34081964
https://pubmed.ncbi.nlm.nih.gov/34081964
Autor:
Rose Lumbroso, Miltiadis Paliouras, Mark Trifiro, Shafinaz F. Chowdhury, Enrico O. Purisima, Lenore K. Beitel
Publikováno v:
Hormones and Cancer. 10:24-35
The androgen-directed treatment of prostate cancer (PCa) is fraught with the recurrent profile of failed treatment due to drug resistance and must be addressed if we are to provide an effective therapeutic option. The most singular difficulty in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c133ea6cb6387ca32bb374a1771a3fc
https://doi.org/10.1007/s12672-018-0353-6
https://doi.org/10.1007/s12672-018-0353-6
Publikováno v:
Toxicology Reports, Vol 4, Iss, Pp 554-559 (2017)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Magnesium stearate is widely used as a food additive. • No published data available related to magnesium stearate genotoxic potential. • Magnesium stearate was evaluated in a battery of genetic toxicity test
Highlights • Magnesium stearate is widely used as a food additive. • No published data available related to magnesium stearate genotoxic potential. • Magnesium stearate was evaluated in a battery of genetic toxicity test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557de33a57bc56f1792031acbfff7651
http://www.sciencedirect.com/science/article/pii/S2214750017300707
http://www.sciencedirect.com/science/article/pii/S2214750017300707
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 3, Iss, Pp 716-722 (2016)
Toxicology Reports, Vol 3, Iss, Pp 716-722 (2016)
Highlights • We evaluated the genotoxicity of ALA-DAG oil using standard tests. • Bacterial reverse mutation and in vitro/in vivo micronucleus tests were conducted. • No genotoxicity was observed under the testing conditions.
The alpha-lin
The alpha-lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe3244b9f5985f649a70a6cb86f7de9
Autor:
Toshio Sofuni
Publikováno v:
Genes and Environment
The evolution of methods to assess genotoxicity of test compounds is thought to be one of the important subjects in The Japanese Environmental and Mutagen Society (JEMS). In 1970, the Ministry of Education of Japan (at that time) organized a research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046b3af24950507b0c257b55e5fd4aad
https://doi.org/10.1186/s41021-016-0063-7
https://doi.org/10.1186/s41021-016-0063-7