Výsledky vyhledávání - "AEs, adverse events"

Safety and immunogenicity of a self-amplifying RNA vaccine against COVID-19: COVAC1, a phase I, dose-ranging trial

Autor: Katrina M. Pollock, Hannah M. Cheeseman, Alexander J. Szubert, Vincenzo Libri, Marta Boffito, David Owen, Henry Bern, Leon R. McFarlane, Jessica O'Hara, Nana-Marie Lemm, Paul McKay, Tommy Rampling, Yee Ting N. Yim, Ana Milinkovic, Cherry Kingsley, Tom Cole, Susanne Fagerbrink, Marites Aban, Maniola Tanaka, Savviz Mehdipour, Alexander Robbins, William Budd, Saul Faust, Hana Hassanin, Catherine A. Cosgrove, Alan Winston, Sarah Fidler, David Dunn, Sheena McCormack, Robin J. Shattock, Kirsty Adams, Fahimah Amini, Nafisah B Atako, Amalina Bakri, Wendy Barclay, Elizabeth Brodnicki, Jonathan C Brown, Ruth Byrne, Rowena Chilvers, Sofia Coelho, Suzanne Day, Monica Desai, Eleanor Dorman, Tamara Elliott, Katie E Flight, James Fletcher, John Galang, Jagruti Gohil, Aneta Gupta, Chris Harlow, Kai Hu, Mohini Kalyan, Dominic Lagrue, Ely Liscano, Cecilia Njenga, Krunal Polra, Derecia A Powlette, Paul Randell, Mary Rauchenberger, Ianto Redknap, Maravic Ricamara, Paul Rogers, Hadijatou Sallah, Karnyart Samnuan, Michael Schumacher, Zareena Shah, Rachel Shaw, Thomas Shaw, Stefan Sivapatham, Susie Slater, Kim Sorley, Regina Storch, Elizabeth Tan, Tricia Tan, Lieze Thielemans, Sarah Whitely, Charlotte Valentine, Jeeva Varghese, Asha Vikraman, Martin Wilkins

Publikováno v: EClinicalMedicine, Vol 44, Iss, Pp 101262-(2022)
EClinicalMedicine

Summary: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as a low dose vaccine against COVID-19. Methods: A phase I first-in-human dose-ranging trial of a saRNA COVID-19 vaccine candidate LNP-nCoVsaR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28acc41920bce70d4d6595fa69b972ce
https://eprints.soton.ac.uk/455190/

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The Effects of a Movement-to-Music (M2M) Intervention on Physical and Psychosocial Outcomes in People Poststroke: A Randomized Controlled Trial

Autor: Cassandra Herman, Hui-Ju Young, Byron Lai, James H. Rimmer, Tapan Mehta, Navneet Kaur Baidwan

Publikováno v: Archives of Rehabilitation Research and Clinical Translation
Archives of Rehabilitation Research and Clinical Translation, Vol 3, Iss 4, Pp 100160-(2021)

Objective: To investigate the effects of a 12-week movement-to-music (M2M) intervention on physical and psychosocial outcomes in people poststroke. Design: Two-arm randomized controlled trial. Setting: A community-based fitness facility. Participants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a33d98164cb3280e82775c49eb96768
https://pubmed.ncbi.nlm.nih.gov/34977542

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Optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis

Autor: Huijie Jiang, Sheng Zhao, Hao Jiang, Xu Zeng, Ruoshui Zheng, Ran Sun, Yanmei Dai

Publikováno v: Translational Oncology
Translational Oncology, Vol 14, Iss 12, Pp 101238-(2021)

Highlights • Sorafenib in combination with TACE can prolong survival in patients with hepatocellular carcinoma. • Compared with TACE + placebo / alone, the combination of TACE and sorafenib can significantly improve the efficacy and safety of hep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b81951a380a5cfd57f90d14e20dcc2
https://pubmed.ncbi.nlm.nih.gov/34628285

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Evaluation of the safety and immunogenicity of the oral inactivated multivalent enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi adults in a double-blind, randomized, placebo-controlled Phase I trial using electrochemiluminescence and ELISA assays for immunogenicity analyses

Publikováno v: Vaccine

Highlights • The killed oral ETEC vaccine ETVAX ± dmLT adjuvant was safe in Bangladeshi adults. • All vaccinees responded to all 5 primary vaccine antigens in ALS specimens. • A majority of vaccinees responded to ≥4 antigens in plasma specim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e25d802401a85c631fd6bd852e4a29
https://doi.org/10.1016/j.vaccine.2018.11.040

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Oral immunotherapy for peanut allergy: The pro argument

Autor: Kari C. Nadeau, Theresa Dunham, R. Sharon Chinthrajah, Sharad Chandra, Shu Cao, Sayantani B. Sindher, Meng Chen, Vanitha Sampath

Publikováno v: World Allergy Organization Journal, Vol 13, Iss 8, Pp 100455-(2020)
The World Allergy Organization Journal

Food allergy (FA) is a growing public health problem with personal, social, nutritional, and economic consequences. In the United States, it is estimated that 8% of children and 10.8% of adults have food allergies. Allergies to peanuts are particular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626306601daa87b0133b314dba2b57c7
http://www.sciencedirect.com/science/article/pii/S1939455120303586

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Safety and therapeutic effects of anti-fibrotic Traditional Chinese Medicine Fuzheng Huayu on persistent advanced stage fibrosis following 2 years entecavir treatment: Study protocol for a single arm clinical objective performance criteria trial

Autor: Haina Fan, Zhimin Zhao, Zheng-Xin Li, Yingchun He, Yangyi Chen, Chenghai Liu

Publikováno v: Contemporary Clinical Trials Communications
Contemporary Clinical Trials Communications, Vol 19, Iss, Pp 100601-(2020)

Background: Hepatitis B virus (HBV) infection is an important etiology for chronic hepatitis globally, and especially so in China. HBV infection can lead to the development of cirrhosis through the pathological process of liver fibrosis. The effectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6512a13cbe689af21cf6786f7ddafb1d
http://europepmc.org/articles/PMC7334581

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Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report

Autor: Koji Iinuma, Takuya Koie, Shigeaki Yokoi, Yuka Muramatsu Maekawa, Manabu Takai, Tomohiro Tsuchiya, Daiki Kato, Keita Nakane

Publikováno v: Urology Case Reports
Urology Case Reports, Vol 31, Iss, Pp-(2020)

We report a fatal case of pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer. A 77-year-old man was aware of eye ptosis and diplopia after three weeks from first infusion of pembrolizumab, an anti-prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177dcd7564e3f83177bff495d220af82
http://europepmc.org/articles/PMC7068635

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Use of pegvaliase in the management of phenylketonuria: Case series of early experience in US clinics

Autor: Joseph W. Ray, Janet A. Thomas, Heather Saavedra, Kea Crivelly, Erika Vucko, Stephanie Sacharow, Heather Bausell, Joshua Lilienstein, Hans C. Andersson, Darius Adams, Jennifer Tiffany-Amaro, Melissa Lah, Kaleigh B. Whitehall, Danielle Starin, Leah B. Wessenberg, Caroline Eggerding, Markey C. McNutt, Kristin Lindstrom

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 28, Iss, Pp 100790-(2021)
Molecular Genetics and Metabolism Reports

Objective To present a case series that illustrates real-world use of pegvaliase based on the initial experiences of US healthcare providers. Methods Sixteen healthcare providers from 14 centers across the US with substantial clinical experience in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46e55e1b8d537526c32804e742f4286
https://doi.org/10.1016/j.ymgmr.2021.100790

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Safety and Efficacy of Amiodarone in a Patient With COVID-19

Autor: Carlo Tascini, Alberto Aimo, Nadia Castaldo, Vincenzo Castiglione, Michele Emdin, Cristiano Padalino

Publikováno v: JACC: case reports, 2(9):1307-1310
JACC: Case Reports
Jacc. Case Reports
JACC: Case Reports, Vol 2, Iss 9, Pp 1307-1310 (2020)

There is an urgent need of effective treatments for COVID-19. Amiodarone, like hydroxychloroquine, exerts antiviral actions by interfering with endocytosis and viral replication. Here we report the first case of a patient affected by respiratory fail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0c911ac506e1170582c60d05a94a01
https://repository.publisso.de/resource/frl:6422479

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The characterisation of pulmonary function in patients with mucopolysaccharidoses IVA: A longitudinal analysis

Autor: Iain A. Bruce, Gabrielle Thompson, Stuart Wilkinson, Simon Jones, Johnny J. Kenth, Catherine Fullwood

Publikováno v: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 20, Iss, Pp-(2019)

Introduction: Mucopolysaccharidosis (MPS) type IVA is a rare, autosomal recessive lysosomal storage disease causing substrate accumulation in various organs and tissues. MPS IVA is associated with both obstructive and restrictive airway disease, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59b71ecd2fe19ea0002572815d35c2f
http://europepmc.org/articles/PMC6629586

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