Dysregulated lipid metabolism networks modulate T-cell function in people with relapsing-remitting multiple sclerosis.

Autor: Martin-Gutierrez, Lucia, Waddington, Kirsty E, Maggio, Annalisa, Coelewij, Leda, Oppong, Alexandra E, Yang, Nina, Adriani, Marsilio, Nytrova, Petra, Farrell, Rachel, Pineda-Torra, Inés, Jury, Elizabeth C

Publikováno v: Clinical & Experimental Immunology; Aug2024, Vol. 217 Issue 2, p204-218, 15p

Impaired in vitro regulatory T cell function associated with Wiskott–Aldrich syndrome

Autor: Adriani, Marsilio, Aoki, Joseph, Horai, Reiko, Thornton, Angela M., Konno, Akihiro, Kirby, Martha, Anderson, Stacie M., Siegel, Richard M., Candotti, Fabio, Schwartzberg, Pamela L.

Publikováno v: In Clinical Immunology 2007 124(1):41-48

Activation of the liver X receptors alters CD4+ T cell membrane lipids and signalling through direct regulation of glycosphingolipid synthesis

Autor: Waddington, Kirsty E, Robinson, George A, Adriani, Marsilio, Rubio-Cuesta, Beatriz, Chrifi-Alaoui, Eden, Andreone, Sara, Poon, Kok-Siong, Ivanova, Iveta, Martin-Gutierrez, Lucia, Owen, Dylan M, Nytrova, Petra, Havrdova, Eva Kubala, Farrell, Rachel, Jury, Elizabeth C, Pineda-Torra, Inés

Summary Liver X Receptors (LXRs) are important transcriptional regulators of intracellular cholesterol, fatty acid, and phospholipid levels. LXRs can dampen inflammation in macrophages by promoting cholesterol efflux and altering plasma membrane lipi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::8b38df07539e8475e56351b7c81ba7f8

Low Percentage of Signal Regulatory Protein alpha/beta(+) Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid Arthritis Patients

Autor: Magill, Laura, Adriani, Marsilio, Berthou, Veronique, Chen, Keguan, Gleizes, Aude, Hacein-Bey-Abina, Salima, Hincelin-Mery, Agnes, Mariette, Xavier, Pallardy, Marc, Spindeldreher, Sebastian, Szely, Natacha, Isenberg, David A., Manson, Jessica J., Jury, Elizabeth C., Mauri, Claudia

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.02865⟩
Frontiers in Immunology, Frontiers, 2018, 9, ⟨10.3389/fimmu.2018.02865⟩

International audience; An important goal for personalized treatment is predicting response to a particular therapeutic. A drawback of biological treatment is immunogenicity and the development of antibodies directed against the drug [anti-drug antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::30ab722066342e32c5d601cc131f31f7
https://hal-cnrs.archives-ouvertes.fr/hal-03295377

Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells

Autor: Bouma, Gerben, Carter, Natalie A, Recher, Mike, Malinova, Dessislava, Adriani, Marsilio, Notarangelo, Luigi D, Burns, Siobhan O, Mauri, Claudia, Thrasher, Adrian J

Publikováno v: EUROPEAN JOURNAL OF IMMUNOLOGY
European Journal of Immunology

Patients deficient in the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing regulatory B (Breg) cells are eme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c5fd130191f1fccb03a86fab6c3d8f62