Zobrazeno 1 - 10
of 39
pro vyhledávání: '"ADP-ribosyl hydrolase"'
Akademický článek
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Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2366-2383 (2021)
ADP-ribosylation is an ancient posttranslational modification present in all kingdoms of life. The system likely originated in bacteria where it functions in inter- and intra-species conflict, stress response and pathogenicity. It was repeatedly adop
Externí odkaz:
https://doaj.org/article/45d0434a8ef94ab7bd1173647b81e2dd
Autor:
Johannes Gregor Matthias Rack, Valentina Zorzini, Zihan Zhu, Marion Schuller, Dragana Ahel, Ivan Ahel
Publikováno v:
Open Biology, Vol 10, Iss 11 (2020)
Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation. This brought them into focus as promising therapeutic
Externí odkaz:
https://doaj.org/article/7c1294537f4343e4bdc6ffb60634f073
Autor:
Rachy Abraham, Robert L. McPherson, Morgan Dasovich, Mohsen Badiee, Anthony K. L. Leung, Diane E. Griffin
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Macrodomain (MD), a highly conserved protein fold present in a subset of plus-strand RNA viruses, binds to and hydrolyzes ADP-ribose (ADPr) from ADP-ribosylated proteins. ADPr-binding by the alphavirus nonstructural protein 3 (nsP3) MD is ne
Externí odkaz:
https://doaj.org/article/f14fda4fa606414e8071d7efbec069d1
Autor:
Voorneveld, J.
Publikováno v:
None
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine. Besides synthetic peptides, this thesis discusses the first synthetic route towards ADP-ribosylated nucleic acids. Furthermore, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::74a90a24538fee88a16fae4c3b3c2bc3
http://hdl.handle.net/1887/3455319
http://hdl.handle.net/1887/3455319
Publikováno v:
Acta Crystallogr F Struct Biol Commun
MacroD2 is one of the three human macrodomain proteins characterized by their protein-linked mono-ADP-ribosyl-hydrolyzing activity. MacroD2 is a single-domain protein that contains a deep ADP-ribose-binding groove. In this study, new crystallization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc7aa0b7f881b5ced183e518fff2295
https://doi.org/10.1107/s2053230x20011309
https://doi.org/10.1107/s2053230x20011309
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Rack, Johannes Gregor Matthias, Zorzini, Valentina, Zhu, Zihan, Schuller, Marion, Ahel, Dragana, Ahel, Ivan
Publikováno v:
Open Biology
Open Biology, Vol 10, Iss 11 (2020)
Open Biology, Vol 10, Iss 11 (2020)
Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation. This brought them into focus as promising therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87310929bfec8f510796aa47a1683aa9
https://lirias.kuleuven.be/handle/123456789/685138
https://lirias.kuleuven.be/handle/123456789/685138
Autor:
Ivan Ahel, Qiang Liu, Luke van Gijlswijk, Johannes Gregor Matthias Rack, Nico J. Meeuwenoord, Dmitri V. Filippov, Gijsbert A. van der Marel, Jim Voorneveld, Herman S. Overkleeft
Publikováno v:
CHEM-EUR J, 27(41), 10621-10627. WILEY-V C H VERLAG GMBH
CHEM-EUR J
Chemistry-a European Journal, 27(41), 10621-10627. WILEY-V C H VERLAG GMBH
Chemistry (Weinheim an Der Bergstrasse, Germany)
CHEM-EUR J
Chemistry-a European Journal, 27(41), 10621-10627. WILEY-V C H VERLAG GMBH
Chemistry (Weinheim an Der Bergstrasse, Germany)
ADP‐ribosylation (ADPr), as a post‐translational modification, plays a crucial role in DNA‐repair, immunity and many other cellular and physiological processes. Serine is the main acceptor for ADPr in DNA damage response, whereas the physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66494211d92f6dc1df6db042e3454b7b
http://hdl.handle.net/1887/3205319
http://hdl.handle.net/1887/3205319
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journa
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2366-2383 (2021)
Computational and Structural Biotechnology Journa
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2366-2383 (2021)
Graphical abstract
ADP-ribosylation is an ancient posttranslational modification present in all kingdoms of life. The system likely originated in bacteria where it functions in inter- and intra-species conflict, stress response and pathogenicity
ADP-ribosylation is an ancient posttranslational modification present in all kingdoms of life. The system likely originated in bacteria where it functions in inter- and intra-species conflict, stress response and pathogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b51c2b5425ad18aa18be73f6f4356b