Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase

Autor: Amalyn Nain-Perez, Anders Foller Füchtbauer, Liliana Håversen, Aleksei Lulla, Chunxia Gao, Josipa Matic, Leticia Monjas, Alexandra Rodríguez, Paul Brear, Woonghee Kim, Marko Hyvönen, Jan Borén, Adil Mardinoglu, Mathias Uhlen, Morten Grøtli

Publikováno v: Nain-Perez, A, Foller Füchtbauer, A, Håversen, L, Lulla, A, Gao, C, Matic, J, Monjas, L, Rodríguez, A, Brear, P, Kim, W, Hyvönen, M, Borén, J, Mardinoglu, A, Uhlen, M & Grøtli, M 2022, ' Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase ', EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 234, 114270 . https://doi.org/10.1016/j.ejmech.2022.114270

Liver pyruvate kinase (PKL) is a major regulator of metabolic flux and ATP production during liver cell glycolysis and is considered a potential drug target for the treatment of non-alcoholic fatty liver disease (NAFLD). In this study, we report the

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https://pubmed.ncbi.nlm.nih.gov/35290845