Výsledky vyhledávání - "ADP, Adenosine diphosphate"

Management of High-Grade Coronary Artery Disease and Concomitant Glanzmann Thrombasthenia

Autor: Aditya Goud, Rushi V. Parikh, Marwah Shahid, Katie P. Truong, Michael H. Rosove, Jesse Currier, Kamran Shamsa, Jessica J. Zhang

Publikováno v: JACC Case Reports
JACC. Case reports, vol 3, iss 14

In the present case report, we describe the management of severe coronary artery disease in a patient with Glanzmann thrombasthenia. To the best of our knowledge, there are no established guidelines for revascularization in this setting, and we pose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffa952178b6d59c03999477a47e2f35
https://doi.org/10.1016/j.jaccas.2021.06.022

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Ginsenosides in Panax genus and their biosynthesis

Autor: Zhengtao Wang, Shujuan Zhao, Rufeng Wang, Maoqi Hou

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1813-1834 (2021)
Acta Pharmaceutica Sinica. B

Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol (PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)- and oleanane (OA)-type saponins known as active compounds of Panax genus. They are accumulated in plant roots, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3ebd6a887266674e75c6007dc0b127
https://doi.org/10.1016/j.apsb.2020.12.017

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The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

Autor: Brian S. J. Blagg, Michael A. Serwetnyk

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1446-1468 (2021)

The 90-kiloDalton (kD) heat shock protein (Hsp90) is a ubiquitous, ATP-dependent molecular chaperone whose primary function is to ensure the proper folding of several hundred client protein substrates. Because many of these clients are overexpressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d551031a93c74226093f0f0844e22506
https://doi.org/10.1016/j.apsb.2020.11.015

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Calmodulin complexes with brain and muscle creatine kinase peptides

Autor: Leila Lo Leggio, J. Sprenger, Emad Tajkhorshid, Ashley Vanderbeck, Jenny Bredfelt, Neal Patel, Sara Linse, Karin S. Åkerfeldt, Roger S. Rowlett, Anda Trifan

Publikováno v: 'Current Research in Structural Biology ', vol: 3, pages: 121-132 (2021)
Current Research in Structural Biology, Vol 3, Iss, Pp 121-132 (2021)
Current research in structural biology 3, 121-132 (2021). doi:10.1016/j.crstbi.2021.05.001
Current Research in Structural Biology
Sprenger, J, Trifan, A, Patel, N, Vanderbeck, A, Bredfelt, J, Tajkhorshid, E, Rowlett, R, Lo Leggio, L, Åkerfeldt, K S & Linse, S 2021, ' Calmodulin complexes with brain and muscle creatine kinase peptides ', Current Research in Structural Biology, vol. 3, pp. 121-132 . https://doi.org/10.1016/j.crstbi.2021.05.001

Current research in structural biology 3, 121-132 (2021). doi:10.1016/j.crstbi.2021.05.001
Calmodulin (CaM) is a ubiquitous Ca$^{2+}$ sensing protein that binds to and modulates numerous target proteins and enzymes during cellular signaling proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3285a54e33aecfb4bc7077adc75e68de
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57915

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A hybrid stochastic/deterministic model of single photon response and light adaptation in mouse rods

Autor: Sabrina Asteriti, Karl-Wilhelm Koch, Charlotte Johanna Beelen, Daniele Dell'Orco, Lorenzo Cangiano

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3720-3734 (2021)
Computational and Structural Biotechnology Journal

Graphical abstract
Highlights • A hybrid stochastic/deterministic model of mouse rod phototransduction is presented. • Rod photocurrent to photovoltage conversion in darkness is accurately characterized. • Photoresponses to dim and bright

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8136acd6ea6a307ba719e270e61c52a1
http://www.sciencedirect.com/science/article/pii/S2001037021002713

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Purinergic signaling in infectious diseases of the central nervous system

Autor: Raíssa Leite-Aguiar, Joyce Pereira da Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, Vinícius Santos Alves

Publikováno v: Brain, Behavior, and Immunity

Highlights • Purinergic signaling is involved in the pathogenesis of neuroinfectious disease. • P2 receptors have pro-inflammatory and deleterious effects in viral Neuroinfections. • ATP-P2X7 receptor signaling contributes to sepsis-associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b36c2eb4e703f769d23badaaa9a5fd
https://doi.org/10.1016/j.bbi.2020.07.026

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Asymptomatic deep vein thrombosis in critically ill COVID-19 patients despite therapeutic levels of anti-Xa activity

Autor: Hugo Rodríguez-Zanella, Claudia Lerma, Sergio Mora-Canela, Victor Manuel Anguiano-Álvarez, Raúl Izaguirre-Ávila, Gustavo Rojas-Velasco, Flavio A Grimaldo-Gómez, Samuel Ramirez-Marroquin, Ángel Ramos-Enríquez, Adriana Torres-Machorro, Edgar García-Cruz, Evelyn Cortina-de la Rosa

Publikováno v: Thrombosis Research

Highlights • Clinical signs are not useful for detecting DVT in critically ill COVID-19 patients • DVT occurs despite full dose anticoagulation in critically ill COVID-19 patients • Severe COVID-19 patients present a high prevalence of bilatera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be3697ec41e74ec3efa4ab7bdb8aba2
http://europepmc.org/articles/PMC7462642

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Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases

Autor: Minki Kim, Muhammad Irfan, Man Hee Rhee

Publikováno v: Journal of Ginseng Research, Vol 44, Iss 1, Pp 24-32 (2020)
Journal of Ginseng Research

Cardiovascular diseases prevail among modern societies and underdeveloped countries, and a high mortality rate has also been reported by the World Health Organization affecting millions of people worldwide. Hyperactive platelets are the major culprit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77592e2f7358ae138f91eeb44c16a0d7
http://www.sciencedirect.com/science/article/pii/S1226845319301332

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Targeting the Mitochondria in Heart Failure

Autor: Hani N. Sabbah

Publikováno v: JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 88-106 (2020)

Visual Abstract
Highlights • Cardiac energy deprivation due to mitochondrial dysfunction is characteristic of heart failure. • Mitochondrial dysfunction contributes to worsening of the heart failure state. • Pharmacologic targeting of mito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf223c5fc74d0943fdde83a16b2755
http://europepmc.org/articles/PMC7000886

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Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model

Autor: Hongchang Gao, Liangcai Zhao, Qingqing Xu, Junjie Yan, Yafei Zheng, Hangying Xu, Chen Li, Qiaoying Jiang, Hong Zheng

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2063-2074 (2020)
Computational and Structural Biotechnology Journal

Graphical abstract
Highlights • Sex-specific metabolic differences occur in all brain regions of mice. • The hippocampal metabolism is more susceptible to T1D. • Metabolic disorders start at the cortex and hippocampus in female T1D mice. �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f4f182a76ce782a14533b123602dc5
http://www.sciencedirect.com/science/article/pii/S2001037020303512

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