Zobrazeno 1 - 10
of 350
pro vyhledávání: '"ADMET prediction"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Background: Drug discovery and development is the extremely costly and time-consuming process of identifying new molecules that can interact with a biomarker target to interrupt the disease pathway of interest. In addition to binding the tar
Externí odkaz:
https://doaj.org/article/13404294b3e3481a9863b450b88f3463
Autor:
M. R.T. Alifiansyah, M. A. Herdiansyah, R. C. Pratiwi, R. P. Pramesti, N. W. Hafsyah, A. P. Rania, Ju. E.R.P. Putra, P. A. Cahyono, Litazkiyyah, S. K. Muhammad, A. A.A. Murtadlo, V. D. Kharisma, A. N.M. Ansori, V. Jakhmola, P. K. Ashok, J. M. Kalra, H. Purnobasuki, I. A. Pratiwi
Publikováno v:
Пищевые системы, Vol 7, Iss 2, Pp 312-320 (2024)
Alizarin is a polycyclic compound isolated from roots of Rubia tinctorum that has potential as a breast anticancer candidate. Increasing anticancer activity can be done through structural modification to produce derivatives in the form of group subst
Externí odkaz:
https://doaj.org/article/510023d5ebe24977af5b4892a5b27a7d
Autor:
Hestining Puspaweni, Bambang Tri Purwanto, Tri Widiandani, Siswandono Siswodihardjo, M. Artabah Muchlisin
Publikováno v:
Borneo Journal of Pharmacy, Vol 7, Iss 3 (2024)
Breast cancer remains a significant public health concern, necessitating the discovery of novel therapeutic agents. This study investigates the potential of thiourea derivatives, specifically HU, HTMX, and BMPTU compounds, as estrogen receptor alpha
Externí odkaz:
https://doaj.org/article/555c54d9d9ef4c04aebc812363efa75a
Autor:
Jurin Mladenka, Stepanić Višnja, Bojanić Krunoslav, Vadlja Denis, Kontrec Darko, Dražić Tonko, Roje Marin
Publikováno v:
Acta Pharmaceutica, Vol 74, Iss 1, Pp 37-59 (2024)
A diastereomeric mixture of racemic 3-phthalimido-b-lactam 2a/2b was synthesized by the Staudinger reaction of carboxylic acid activated with 2-chloro-1-methylpyridinium iodide and imine 1. The amino group at the C3 position of the b-lactam ring was
Externí odkaz:
https://doaj.org/article/199e7ac933ef4756b379fef727260399
Autor:
Tao Gao, Sheng-lin Hu, Rui Yan, Ling-zhi He, Nan Fang, Zhong-hao Zhang, Zhi-hao Duan, Zi-zhong Tang, Yang-er Chen, Shu Yuan, Lin Ye, Xiao-rong Yan, Ming Yuan
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 6, Pp 105793- (2024)
Alismatis Rhizoma (AR) is a crucial substance for discovering new triterpenoids to address hyperlipidemia and obesity. Currently, approximately 120 triterpenoids have been identified in AR, making the discovery of new triterpenoids increasingly chall
Externí odkaz:
https://doaj.org/article/d9ef03b601eb41848030c2abb0292d82
Autor:
Mariscal Brice Tchatat Tali, Eugenie Aimée Madiesse Kemgne, Cedric Derick Jiatsa Mbouna, Marius Jaures Tsakem Nangap, Aubin Youbi Kamche, Souleyman Hassan, Jean Claude Tchouankeu, Fabrice Fekam Boyom
Publikováno v:
International Journal of Plant Based Pharmaceuticals, Vol 4, Iss 1 (2024)
Due to the spreading resistance to antimalarial drugs, new therapeutics are urgently needed, preferably with novel modes of action. Extracts from Terminalia ivorensis have previously been shown to possess activity in vitro against multidrug-resistant
Externí odkaz:
https://doaj.org/article/9e914e994feb40bdbf691564e9c59ca0
Autor:
Muhammad Akbar S Kurniawan, Muhamad Jalil Baari, Sariyanti Sariyanti, Finarisnawati Finarisnawati
Publikováno v:
Jurnal Kimia Riset, Vol 8, Iss 2, Pp 186-199 (2023)
Malaria is a serious caused by protozoan parasites such as Plasmodium groups and has fatal consequences for human health. The increase in the resistance of the Plasmodium parasites toward existing antimalarial drugs prompts the exploration of novel c
Externí odkaz:
https://doaj.org/article/cabbf6497a25456980d1fb3cedd12472
Publikováno v:
Advances and Applications in Bioinformatics and Chemistry, Vol Volume 16, Pp 61-91 (2023)
Demis Zelelew,1 Milkyas Endale,1 Yadessa Melaku,1 Teshome Geremew,2 Rajalakshmanan Eswaramoorthy,3 Lemma Teshome Tufa,1,4 Youngeun Choi,5 Jaebeom Lee5 1Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology U
Externí odkaz:
https://doaj.org/article/a7f890a413c74bd4a39e883af81dee0e
Autor:
Vijay Nayak Bhukya, Durga Prasad Beda
Publikováno v:
Green Analytical Chemistry, Vol 8, Iss , Pp 100090- (2024)
Panobinostat (PAN) is an inhibitor of histone deacetylase (HDAC) that has been granted approval by the US Regulator for the purpose of treating chronic lymphocytic leukemia. Stress studies were conducted on PAN to assess its inherent stability under
Externí odkaz:
https://doaj.org/article/db290fa9bf094bf0a21cf4388402c924
Publikováno v:
Journal of Basic Research in Medical Sciences, Vol 10, Iss 3, Pp 62-71 (2023)
Introduction: Elevated plasma LDL cholesterol levels play a crucial role in cardiovascular disease development. Squalene synthase (SQS), a regulatory enzyme in cholesterol biosynthesis, is a target for controlling hypercholesterolemia. Traditional me
Externí odkaz:
https://doaj.org/article/caeee9bf0ea541459f617e629dd12da0