Zobrazeno 1 - 10
of 12 221
pro vyhledávání: '"ADME"'
Autor:
Caroline König, Alfredo Vellido
Publikováno v:
BioData Mining, Vol 17, Iss 1, Pp 1-25 (2024)
Abstract Purpose The analysis of absorption, distribution, metabolism, and excretion (ADME) molecular properties is of relevance to drug design, as they directly influence the drug’s effectiveness at its target location. This study concerns their p
Externí odkaz:
https://doaj.org/article/b2fd006461574070badfbfb3b006cb7d
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Background Antimicrobial resistance among pathogens is an emerging problem, gaining significant importance recently. Pharmaceutical scientists are constantly exploring innovative and effective antibacterial agents. Pseudomonas aeruginosa (P.
Externí odkaz:
https://doaj.org/article/7d7d702793c745adaa10c501905d3d8b
Autor:
Muhammad Naveed, Khushbakht Javed, Tariq Aziz, Amina Abid, Hafiz Muzzammel Rehman, Metab Alharbi, Abdulrahman Alshammari, Abdullah F. Alasmari
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Hepatocellular carcinoma (HCC) incidence varies widely around the world and is impacted by factors such as the prevalence of chronic hepatitis B and C infections, alcohol intake, and access to healthcare. The proteins (BRAF_human, VGFR3_huma
Externí odkaz:
https://doaj.org/article/d788ccbbfb144893b6d777828392c616
Autor:
Haiyu Zhang, Weisheng Huang, Mutong Chen, Yuhan Liu, Bing Yan, Shuanzhu Mou, Wendong Jiang, Hongbing Mei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Genes involved in drug absorption, distribution, metabolism, and excretion (ADME) are named ADME genes. However, the comprehensive role of ADME genes in kidney renal clear cell carcinoma (KIRC) remains unclear. Using the clinical and gene ex
Externí odkaz:
https://doaj.org/article/e6886460a42a4c2abd55f8e3799542a2
Autor:
Shabana Islam, Erum Akbar Hussain, Shahida Shujaat, Muhammad Umer Khan, Qurban Ali, Saif Ul Malook, Daoud Ali
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract The issue of antibiotic resistance in pathogenic microbes is a global concern. This study was aimed to explore in silico and in vitro analysis of the antibacterial efficacy of different natural ligands against bacterial activity. The ligands
Externí odkaz:
https://doaj.org/article/0680a01be52b4de188cd8317c2ef8fec
Autor:
Jae Hun Ahn, Min Hwan Kim, Kyongkyu Lee, Keumrok Oh, Hyunwoo Lim, Hee Seup Kil, Soon Jeong Kwon, Jae Yong Choi, Dae Yoon Chi, Yong Jin Lee
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Background N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT), the representative cocaine derivative used in dopamine transporter imaging, is a promising biomarker, as it reflects the severity of Parkinson’s disea
Externí odkaz:
https://doaj.org/article/1439753c4ac34c389c845621de74365d
Autor:
Ping Yu, Tanwei Gu, Yueyang Rao, Weimin Liang, Xi Zhang, Huanguo Jiang, Jindi Lu, Jianglian She, Jianmin Guo, Wei Yang, Yonghong Liu, Yingfeng Tu, Lan Tang, Xuefeng Zhou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3232-3250 (2024)
Insufficient therapeutic strategies for acute kidney injury (AKI) necessitate precision therapy targeting its pathogenesis. This study reveals the new mechanism of the marine-derived anti-AKI agent, piericidin glycoside S14, targeting peroxiredoxin 1
Externí odkaz:
https://doaj.org/article/d25b34968aac42819ebddcb13d0f09a5
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Background In this work, we represent synthesis, in silico analysis and biological activity of 1,4 diazepine linked piperidine derivatives (6a–6o). All the derivatives were screened for their anti-microbial activity against gram-positive (
Externí odkaz:
https://doaj.org/article/3b2b53da2e484131a0d2d774e5e6e3df
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Natural products play a significant role in providing the current demand as antiparasitic agents, which offer an attractive approach for the discovery of novel drugs. The present study aimed to evaluate in vitro the potential impact of seawe
Externí odkaz:
https://doaj.org/article/e9d021cfca394cc694277c3a0cc73760
Autor:
Lenin Nachimuthu, Rajagopal Desikan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract The emphasis on sustainable sources of drug development seems imminent with phytochemicals emerging as promising candidates due to their minimal probability of adverse effects. This study focuses on utilizing simple cinnamic acid and nicotin
Externí odkaz:
https://doaj.org/article/be319978a5c14552a0f26f88affeda88