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Akademický článek

The role of actin cytoskeleton CFL1 and ADF/cofilin superfamily in inflammatory response

Autor: Jianxiao Xing, Ying Wang, Aihong Peng, Junqin Li, Xuping Niu, Kaiming Zhang

Publikováno v: Frontiers in Molecular Biosciences, Vol 11 (2024)

Actin remodeling proteins are important in immune diseases and regulate cell cytoskeletal responses. These responses play a pivotal role in maintaining the delicate balance of biological events, protecting against acute or chronic inflammation in a r

Externí odkaz: https://doaj.org/article/5930a8e797884bf3baac99f24a68d170

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Akademický článek

Molecular and structural basis of actin filament severing by ADF/cofilin

Autor: Sharad V. Jaswandkar, Kalpana S. Katti, Dinesh R. Katti

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4157-4171 (2022)

ADF/cofilin’s cooperative binding to actin filament modifies the conformation and alignment of G-actin subunits locally, causing the filament to sever at “boundaries” formed among bare and ADF/cofilin-occupied regions. Analysis of the impact of

Externí odkaz: https://doaj.org/article/b780c420aa8d4b46b4c6f33c90e284c4

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Akademický článek

The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer’s Disease

Autor: Youssif Ben Zablah, Neil Merovitch, Zhengping Jia

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Actin-depolymerization factor (ADF)/cofilin, a family of actin-binding proteins, are critical for the regulation of actin reorganization in response to various signals. Accumulating evidence indicates that ADF/cofilin also play important roles in neu

Externí odkaz: https://doaj.org/article/640355bb747b46118aa9ba9795764776

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Akademický článek

Coactosin Phosphorylation Controls Entamoeba histolytica Cell Membrane Protrusions and Cell Motility

Autor: Muhammad M. Hasan, José E. Teixeira, Ying-Wai Lam, Christopher D. Huston

Publikováno v: mBio, Vol 11, Iss 4 (2020)

ABSTRACT Invasion of the colon wall by Entamoeba histolytica during amoebic dysentery entails migration of trophozoites through tissue layers that are rich in extracellular matrix. Transcriptional silencing of the E. histolytica surface metalloprotea

Externí odkaz: https://doaj.org/article/cde7775a75114ada93f1cfd3282f8755

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