Zobrazeno 1 - 10
of 4 397
pro vyhledávání: '"ADCC"'
Autor:
Sylvia Zöphel, Nadja Küchler, Johanna Jansky, Cora Hoxha, Gertrud Schäfer, Julius J. Weise, Joanne Vialle, Lea Kaschek, Gebhard Stopper, Hermann Eichler, Daniela Yildiz, Alina Moter, Philipp Wendel, Evelyn Ullrich, Claudia Schormann, Torben Rixecker, Onur Cetin, Frank Neumann, Patrick Orth, Moritz Bewarder, Markus Hoth, Lorenz Thurner, Eva C. Schwarz
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Assessing the prognosis of patients with aggressive non-Hodgkin B cell lymphoma mainly relies on a clinical risk score (IPI). Standard first-line therapies are based on a chemo-immunotherapy with rituximab, which mediates CD16-dependent anti
Externí odkaz:
https://doaj.org/article/c26da19e6df140a2bd9fa86950fc9b73
Autor:
Jason Tasoulas, Travis P. Schrank, Harish Bharambe, Jay Mehta, Steven Johnson, Kimon Divaris, Trevor G. Hackman, Siddharth Sheth, Kedar Kirtane, Juan C. Hernandez-Prera, Christine H. Chung, Wendell G. Yarbrough, Renata Ferrarotto, Natalia Issaeva, Stamatios Theocharis, Antonio L. Amelio
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Adenoid cystic carcinoma (AdCC) is a slow-growing salivary gland malignancy that relapses frequently. AdCCs of the submandibular gland exhibit unique differences in prognosis and treatment response to adjuvant radiotherapy compared to other
Externí odkaz:
https://doaj.org/article/dcc8fd92e705442c9ebdfb5df85e4bce
Autor:
Anna R. Mahr, Maia M. C. Bennett-Boehm, Frederik H. Rothemejer, Isabelle S. Weber, Alexander K. Regan, Josh Q. Franzen, Cami R. Bisson, Angela N. Truong, Rikke Olesen, Mariane H. Schleimann, Claudia M. Rauter, Audrey L. Smith, Dalia El-Gamal, Ole S. Søgaard, Martin Tolstrup, Paul W. Denton
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract There are two known mechanisms by which natural killer (NK) cells recognize and kill diseased targets: (i) direct killing and (ii) antibody-dependent cell-mediated cytotoxicity (ADCC). We investigated an indirect NK cell activation strategy
Externí odkaz:
https://doaj.org/article/85906b314a2a4acaaca1f37e36865354
Autor:
Yinjie Liang, Junjia Guo, Zhen Li, Shiyuan Liu, Ting Zhang, Shucai Sun, Funa Lu, Yuqian Zhai, Wenling Wang, Chuanyi Ning, Wenjie Tan
Publikováno v:
Biosafety and Health, Vol 6, Iss 3, Pp 178-185 (2024)
The matrix protein 2 (M2) is a preferred target for developing a universal vaccine against the influenza A virus (IAV). This study aimed to develop a method for assessing antibody-dependent cell-mediated cytotoxicity (ADCC) associated with M2-based i
Externí odkaz:
https://doaj.org/article/11ff126d9fd04d37aeafc2ce2f986a51
Publikováno v:
eLife, Vol 13 (2024)
Both endogenous antibodies and a subset of antibody therapeutics engage Fc gamma receptor (FcγR)IIIa/CD16a to stimulate a protective immune response. Increasing the FcγRIIIa/IgG1 interaction improves the immune response and thus represents a strate
Externí odkaz:
https://doaj.org/article/fa1b98bab8f749aba01b8fcf353de5c5
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 10, Pp 100977- (2024)
Trastuzumab has improved survival rates in human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC), but drug resistance leads to treatment failure. Natural killer (NK) cell-mediated antibody-dependent cell cytotoxicity (ADCC) repr
Externí odkaz:
https://doaj.org/article/6b3649ef1f604c7da224a314d7c2ae85
Autor:
Mohammad Arif Rahman, Isabela Silva de Castro, Luca Schifanella, Massimiliano Bissa, Genoveffa Franchini
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
SIV and HIV-based envelope V1-deleted (ΔV1) vaccines, delivered systemically by the DNA/ALVAC/gp120 platform, decrease the risk of mucosal SIV or SHIV acquisition more effectively than V1-replete vaccines. Here we investigated the induction of mucos
Externí odkaz:
https://doaj.org/article/5e6a82b3d6df4b6a8438171f1e32dd9d
Autor:
Lara V. Graham, Jack G. Fisher, Amber D. P. Doyle, Ben Sale, Luis Del Rio, Albert J. E. French, Neema P. Mayor, Thomas R. Turner, Steven G. E. Marsh, Mark S. Cragg, Francesco Forconi, Salim I. Khakoo, Matthew D. Blunt
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Strategies to mobilise natural killer (NK) cells against cancer include tumour-targeting antibodies, NK cell engagers (NKCEs) and the adoptive transfer of ex vivo expanded healthy donor-derived NK cells. Genetic and functional studies have revealed t
Externí odkaz:
https://doaj.org/article/fd7b4fde3c474160a80992b35087e833
Publikováno v:
International Journal of Emerging Markets, 2022, Vol. 19, Issue 5, pp. 1359-1384.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/IJOEM-09-2021-1420
Autor:
Maria C. Rodriguez Benavente, Zainab A. Hakeem, Alexander R. Davis, Nathan B. Murray, Parastoo Azadi, Emily M. Mace, Adam W. Barb
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Natural killer (NK) cells destroy tissue that have been opsonized with antibodies. Strategies to generate or identify cells with increased potency are expected to enhance NK cell-based immunotherapies. We previously generated NK cells with i
Externí odkaz:
https://doaj.org/article/af037a6d23824e0396d24c7b526b7a61