A Randomized Comparison of Postprandial Glucose Excursion Using Inhaled Insulin Versus Rapid-Acting Analog Insulin in Adults With Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery.

Autor: Hirsch IB; University of Washington, Seattle, WA., Beck RW; JAEB Center for Health Research, Tampa, FL., Marak MC; JAEB Center for Health Research, Tampa, FL., Calhoun P; JAEB Center for Health Research, Tampa, FL., Mottalib A; Joslin Diabetes Center, Boston, MA., Salhin A; Diabetes & Glandular Disease Clinic, San Antonio, TX., Manessis A; NYC Research, Inc., Long Island, NY., Coviello AD; University of North Carolina, Chapel Hill, NC., Bhargava A; Iowa Diabetes and Endocrinology Research Center, West Des Moines, IA., Thorsell A; Sansum Diabetes Research Institute, Santa Barbara, CA., Atakov Castillo A; Boston Medical Center, Boston, MA., Bode BW; Atlanta Diabetes Associates, Atlanta, GA., Levister C; Icahn School of Medicine at Mount Sinai, New York, NY., Levy CJ; Icahn School of Medicine at Mount Sinai, New York, NY., Donahue C; University of North Carolina, Chapel Hill, NC., Cordero C; Loma Linda University, Loma Linda, CA., Beatson C; Barbara Davis Center for Diabetes, Denver, CO., Langel CR; Iowa Diabetes and Endocrinology Research Center, West Des Moines, IA., Jacobson C; Loma Linda University, Loma Linda, CA., Kurek C; Mayo Clinic, Rochester, MN., Cruse D; Mountain State Diabetes, Parkersburg, WV., Pickering D; Mountain State Diabetes, Parkersburg, WV., Tamarez D; Icahn School of Medicine at Mount Sinai, New York, NY., Steenkamp DW; Boston Medical Center, Boston, MA., Desjardins D; Mayo Clinic, Rochester, MN., Aleppo G; Northwestern University, Chicago, IL., O'Malley G; Icahn School of Medicine at Mount Sinai, New York, NY., Akturk HK; Barbara Davis Center for Diabetes, Denver, CO., Diner J; University of North Carolina, Chapel Hill, NC., Baran JD; University of Washington, Seattle, WA., Buse JB; University of North Carolina, Chapel Hill, NC., Ruedy K; JAEB Center for Health Research, Tampa, FL., Codorniz K; Loma Linda University, Loma Linda, CA., Klein KR; University of North Carolina, Chapel Hill, NC., Castorino K; Sansum Diabetes Research Institute, Santa Barbara, CA., Jordan LF; University of Texas Southwestern, Dallas, TX., Kipnes M; Diabetes & Glandular Disease Clinic, San Antonio, TX., Church MM; Sansum Diabetes Research Institute, Santa Barbara, CA., Hamdy O; Joslin Diabetes Center, Boston, MA., Raskin P; University of Texas Southwestern, Dallas, TX., Nguyen QT; Las Vegas Endocrinology, Henderson, NV., Weinstock RS; SUNY Upstate Medical University, Syracuse, NY., Lee S; Loma Linda University, Loma Linda, CA., Rizvi S; Mayo Clinic, Rochester, MN., Bzdick S; Boston Medical Center, Boston, MA., Ghorbani Rodriguez T; University of North Carolina, Chapel Hill, NC., Salah T; Joslin Diabetes Center, Boston, MA., Blevins T; Texas Diabetes & Endocrinology, Austin, TX., Kudva YC; Mayo Clinic, Rochester, MN., Haider Z; Barbara Davis Center for Diabetes, Denver, CO.

Publikováno v: Diabetes care [Diabetes Care] 2024 Sep 01; Vol. 47 (9), pp. 1682-1687.

Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.

Autor: Eriksson AL; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden., Perry JRB; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom.; University of Exeter Medical School, University of Exeter, Exeter, United Kingdom., Coviello AD; Duke University School of Medicine, Durham, North Carolina., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ferrucci L; Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland., Hoffman AR; Division of Endocrinology, Stanford University School of Medicine, Stanford, California., Huhtaniemi IT; Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, United Kingdom.; Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland., Ikram MA; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Karlsson MK; Department of Orthopaedics and Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Laughlin GA; Family Medicine and Public Health, University of California-San Diego, San Diego, California., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina., Lorentzon M; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg and Geriatric Medicine, Sahlgrenska University Hospital, Mölndal, Sweden., Lunetta KL; Boston University School of Public Health, Boston, Massachusetts.; Framingham Heart Study, Framingham, Massachusetts., Mellström D; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg and Geriatric Medicine, Sahlgrenska University Hospital, Mölndal, Sweden., Murabito JM; Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts., Murray A; University of Exeter Medical School, University of Exeter, Exeter, United Kingdom., Nethander M; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden., Nielson CM; School of Public Health, Oregon Health & Science University, Portland, Oregon., Prokopenko I; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom.; Hammersmith Hospital, London, United Kingdom., Pye SR; Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom., Raffel LJ; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, California., Rivadeneira F; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Srikanth P; School of Public Health, Oregon Health & Science University, Portland, Oregon., Stolk L; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Travison TG; Institute for Aging Research, Hebrew Senior Life and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts., Uitterlinden AG; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Vaidya D; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Vanderschueren D; Department of Clinical and Experimental Medicine, Katholieke Universiteit Leuven, Laboratory of Clinical and Experimental Endocrinology, Leuven, Belgium., Zmuda JM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania., März W; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Orwoll ES; Bone & Mineral Unit, Oregon Health & Science University, Portland, Oregon., Ouyang P; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Vandenput L; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden., Wu FCW; Andrology Research Unit, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester, United Kingdom., de Jong FH; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Bhasin S; Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Kiel DP; Framingham Heart Study, Framingham, Massachusetts.; Institute for Aging Research, Hebrew Senior Life and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts., Ohlsson C; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2018 Mar 01; Vol. 103 (3), pp. 991-1004.

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Autor: Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Lunetta KL; Boston University School of Public Health, Department of Biostatistics. Boston, Massachusetts 02118, USA.; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA., Pervjakova N; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115, USA., Stolk L; Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands., Finucane HK; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA., Sulem P; deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland., Bulik-Sullivan B; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US., Esko T; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA., Johnson AD; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA., Elks CE; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA., He C; Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA., Altmaier E; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle Washington 98101 USA., Franke LL; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands., Huffman JE; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Keller MF; Merck Pharmaceuticals, 33 Avenue Louis Pasteur, Boston, MA 02115, United States., McArdle PF; Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201., Nutile T; Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy., Porcu E; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.; University of Sassari, Department of Biomedical Sciences, Sassari, 07100 Sassari, Italy.; Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', 34137 Trieste, Italy., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215., Schick UM; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy., Vuckovic D; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', 34137 Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany., Amin N; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands., Corre T; Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland.; Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland., Hottenga JJ; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland., Tanaka T; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America., Abecasis G; Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA., Andrulis IL; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Anton-Culver H; Department of Epidemiology, University of California Irvine, Irvine, California, USA., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Arndt V; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Arnold AM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Barbieri C; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', 34137 Trieste, Italy.; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy., Beckmann MW; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany., Beeghly-Fadiel A; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Benitez J; Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain., Bernstein L; Beckman Research Institute of City of Hope, Duarte, CA, USA., Bielinski SJ; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Blomqvist C; Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Boerwinkle E; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Bogdanova NV; Department of Radiation Oncology, Hannover Medical School, Hannover, Germany., Bojesen SE; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Borresen-Dale AL; Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Boutin TS; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Brauch H; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Brüning T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany., Burwinkel B; Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.; Molecular Biology of Breast Cancer, Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany., Campbell A; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Campbell H; Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Chapman JR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA., Chenevix-Trench G; Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Coviello AD; Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA., Cox A; Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK., Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden., Darabi H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden., De Vivo I; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Demerath EW; Division of Epidemiology & Community Health, University of Minnesotta, Minneapolis MN 55455., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Devilee P; Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Dos-Santos-Silva I; Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK., Eicher JD; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA., Fasching PA; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.; David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Figueroa J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Flesch-Janys D; Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany.; Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany., Gandin I; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', 34137 Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., García-Closas M; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.; Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Giles GG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia., Girotto GG; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy., Goldberg MS; Department of Medicine, McGill University, Montreal, Canada.; Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Canada., González-Neira A; Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Goodarzi MO; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA., Grove ML; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Gudbjartsson DF; deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland., Guénel P; Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France.; University Paris-Sud, UMRS 1018, Villejuif, France., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden., Hamann U; Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Henderson BE; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hocking LJ; Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK., Hofman A; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany., Hooning MJ; Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Hu FB; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Huang J; State Key Laboratory of Medical Genomics,Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Humphreys K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden., Hunter DJ; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Jones SE; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Kabisch M; Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Karasik D; Harvard Medical School, Boston, MA 02115, USA.; Hebrew SeniorLife Institute for Aging Research, Boston, MA, 02131, USA., Knight JA; Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Kolcic I; Faculty of Medicine, University of Split, Split, Croatia., Kooperberg C; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA., Kosma VM; Cancer Center, Kuopio University Hospital, Kuopio, Finland.; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Kriebel J; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; German Center for Diabetes Research, 85764 Neuherberg, Germany., Kristensen V; Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway., Lambrechts D; Vesalius Research Center (VRC), VIB, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Li J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden., Li X; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Lindström S; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Lubinski J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Mägi R; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Mannermaa A; Cancer Center, Kuopio University Hospital, Kuopio, Finland.; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Manz J; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany., Margolin S; Department of Oncology - Pathology, Karolinska Institutet, Stockholm 17177, Sweden., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Masciullo C; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy., Meindl A; Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany., Michailidou K; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Milne RL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Department of Medicine I, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Nalls M; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Neale BM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Neven P; KULeuven (University of Leuven), Department of Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Belgium., Newman AB; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Nordestgaard BG; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark., Olson JE; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA., Padmanabhan S; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Peterlongo P; IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy., Peters U; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA., Petersmann A; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Peto J; Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK., Pharoah PDP; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK., Pirastu NN; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', 34137 Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy., Pirie A; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Pistis G; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.; University of Sassari, Department of Biomedical Sciences, Sassari, 07100 Sassari, Italy.; Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Porteous D; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle Washington 98101 USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA.; Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA.; Department of Health Services, University of Washington, Seattle, Washington 98101, USA., Pylkäs K; Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu, Finland.; Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Raffel LJ; Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.; UCLA Clinical & Translational Science Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Rivadeneira F; Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands., Rudan I; Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Rudolph A; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ruggiero D; Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy., Sala CF; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy., Sanna S; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy., Sawyer EJ; Research Oncology, Guy's Hospital, King's College London, London, UK., Schlessinger D; National Institute on Aging, Intramural Research Program, Baltimore, MD 20892, USA., Schmidt MK; Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands., Schmidt F; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany., Schmutzler RK; Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany.; Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.; Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany., Schoemaker MJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Seynaeve CM; Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands., Simard J; Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada., Sorice R; Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy., Southey MC; Department of Pathology, The University of Melbourne, Melbourne, Australia., Stöckl D; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany., Swerdlow A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.; Division of Breast Cancer Research, The Institute of Cancer Research, London, UK., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA., Thorsteinsdottir U; deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland., Toland AE; Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Tomlinson I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK., Truong T; Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France.; University Paris-Sud, UMRS 1018, Villejuif, France., Tryggvadottir L; Icelandic Cancer Registry, Reykjavik, Iceland., Turner ST; Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Vozzi D; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', 34137 Trieste, Italy., Wang Q; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Wellons M; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, 37203, USA., Willemsen G; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Wilson JF; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.; Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Winqvist R; Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu, Finland.; Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland., Wolffenbuttel BBHR; Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Wright AF; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Yannoukakos D; Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos', Athens, Greece., Zemunik T; Faculty of Medicine, University of Split, Split, Croatia., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Zygmunt M; Department of Obstetrics and Gynecology, University Medicine Greifswald, 17475 Greifswald, Germany., Bergmann S; Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland.; Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland., Boomsma DI; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115, USA., Ferrucci L; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., van Duijn CM; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands., Alizadeh BZ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Ciullo M; Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy., Crisponi L; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK., Gasparini PP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', 34137 Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kraft P; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., McKnight B; Department of Biostatistics, University of Washington, Seattle, WA, USA., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Morrison AC; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Reiner AP; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA., Toniolo D; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy., Uitterlinden AG; Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', 34137 Trieste, Italy., Völzke H; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Yerges-Armstrong LM; Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201., Price AL; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Stefansson K; deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland., Visser JA; Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Department of Paediatrics,University of Cambridge,Cambridge, CB2 0QQ, UK., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Murabito JM; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.; Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Murray A; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.

Publikováno v: Nature genetics [Nat Genet] 2015 Nov; Vol. 47 (11), pp. 1294-1303. Date of Electronic Publication: 2015 Sep 28.

Rare coding variants and X-linked loci associated with age at menarche.

Autor: Lunetta KL; 1] Boston University School of Public Health, Department of Biostatistics, Boston, Massachusetts 02118, USA [2] NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Sulem P; deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland., Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Tung JY; 23andMe Inc., 1390 Shorebird Way, Mountain View, California 94043, USA., Hinds DA; 23andMe Inc., 1390 Shorebird Way, Mountain View, California 94043, USA., Esko T; 1] Estonian Genome Center, University of Tartu, Tartu 51010, Estonia [2] Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA [3] Department of Genetics, Harvard Medical School, Boston, MA 02115, USA [4] Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140, Cambridge, MA 02142, USA., Elks CE; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Altmaier E; 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany., He C; 1] Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA [2] Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA., Huffman JE; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Porcu E; 1] Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy [2] University of Sassari, Department of Biomedical Sciences, Sassari, Sassari 07100, Italy [3] Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA., Robino A; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste 34137, Italy., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215., Schick UM; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA., Stolk L; Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, the Netherlands., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano 20132, Italy., Wang CA; School of Women's and Infants' Health, The University of Western Australia, WA-6009, Australia., Yerges-Armstrong LM; Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition-University of Maryland School of Medicine, Baltimore, MD 21201, USA., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Barbieri C; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano 20132, Italy., Coviello AD; Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA, USA., Cucca F; 1] Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy [2] University of Sassari, Department of Biomedical Sciences, Sassari, Sassari 07100, Italy., Demerath EW; Division of Epidemiology &Community Health, University of Minnesotta, Minneapolis, MN 55455, USA., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Gandin I; 1] Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste 34137, Italy [2] Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste 34149, Italy., Grove ML; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Gudbjartsson DF; 1] deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland [2] School of Engineering and Natural Sciences, University of Iceland, Reykjavik IS-101, Iceland., Hocking LJ; Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK., Hofman A; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, the Netherlands., Huang J; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Jackson RD; Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA., Karasik D; 1] Hebrew SeniorLife Institute for Aging Research, Boston, MA 02131, USA [2] Harvard Medical School, Boston, MA 02115, USA., Kriebel J; 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] German Center for Diabetes Research, Neuherberg 85764, Germany., Lange EM; 1] Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA [2] Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA., Lange LA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Li X; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Morrison AC; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Padmanabhan S; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Pirie A; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Porteous D; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Reiner AP; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA., Rivadeneira F; 1] Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, the Netherlands [2] Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, the Netherlands., Rudan I; Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland., Sala CF; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano 20132, Italy., Schlessinger D; National Institute on Aging, Intramural Research Program, Baltimore, MD 20892, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Stöckl D; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany., Visser JA; Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, the Netherlands., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany., Vozzi D; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste 34137, Italy., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA., Zygmunt M; Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald 17475, Germany., Boerwinkle E; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Buring JE; 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215 [2] Harvard Medical School, Boston, MA 02115, USA., Crisponi L; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy., Easton DF; 1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Hu FB; 1] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [3] Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Liu S; Departments of Epidemiology and Medicine Brown University, Brown University, Providence, RI 02912, USA., Metspalu A; 1] Estonian Genome Center, University of Tartu, Tartu 51010, Estonia [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Pennell CE; School of Women's and Infants' Health, The University of Western Australia, WA-6009, Australia., Ridker PM; 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215 [2] Harvard Medical School, Boston, MA 02115, USA., Strauch K; 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich 81377, Germany., Streeten EA; Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition-University of Maryland School of Medicine, Baltimore, MD 21201, USA., Toniolo D; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano 20132, Italy., Uitterlinden AG; 1] Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, the Netherlands [2] Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, the Netherlands., Ulivi S; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste 34137, Italy., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Wellons M; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA., Chasman DI; 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215 [2] Harvard Medical School, Boston, MA 02115, USA., Thorsteinsdottir U; 1] deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland [2] Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland., Murray A; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Stefansson K; 1] deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland [2] Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland., Murabito JM; 1] NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA [2] Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA., Ong KK; 1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK [2] Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Perry JR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

Publikováno v: Nature communications [Nat Commun] 2015 Aug 04; Vol. 6, pp. 7756. Date of Electronic Publication: 2015 Aug 04.

Association of sex hormones, aging, and atrial fibrillation in men: the Framingham Heart Study.

Autor: Magnani JW; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Boston, MA., Moser CB, Murabito JM, Sullivan LM, Wang N, Ellinor PT, Vasan RS, Benjamin EJ, Coviello AD

Publikováno v: Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2014 Apr; Vol. 7 (2), pp. 307-12. Date of Electronic Publication: 2014 Mar 08.