Výsledky vyhledávání - "AD, Alzheimer disease"

Gains from no real PAINS: Where ‘Fair Trial Strategy’ stands in the development of multi-target ligands

Autor: Jianbo Sun, Hui Zhong, Li Chen, Na Li, Kun Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3417-3432 (2021)

Compounds that selectively modulate multiple targets can provide clinical benefits and are an alternative to traditional highly selective agents for unique targets. High-throughput screening (HTS) for multitarget-directed ligands (MTDLs) using approv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862abd0b2f76391c84b2238b548f152a
https://doi.org/10.1016/j.apsb.2021.02.023

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Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach

Autor: Abdah Md Akim, Yazan Ranneh, Azizul Isha, Nur Amalina Ismail, Faridah Kormin, Maryati Mohamed, Mohd Fadzelly Abu Bakar

Publikováno v: Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 6711-6720 (2021)

Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b538f9b539735e08d38418e62ff85a5f
http://europepmc.org/articles/PMC8626306

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Akademický článek

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Amino acid sequence homology between thyroid autoantigens and central nervous system proteins: Implications for the steroid-responsive encephalopathy associated with autoimmune thyroiditis

Autor: Salvatore Benvenga, Alessandro Antonelli, Carmen Bonanno, Poupak Fallahi, Carmelo Rodolico, Fabrizio Guarneri

Publikováno v: Journal of Clinical & Translational Endocrinology, Vol 26, Iss, Pp 100274-(2021)
Journal of Clinical & Translational Endocrinology

Highlights • Alpha-enolase, aldehyde reductase-I and dimethylargininase-I are SREAT autoantigens. • Molecular mimicry between thyroid and CNS autoantigens is hypothesized in SREAT. • Homology with TSH-R, Tg and TPO exists for 6, 27 and 47 of 46

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e961c0dafeeda47c6b307edcb07941d6
http://www.sciencedirect.com/science/article/pii/S2214623721000260

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The aminosterol Claramine inhibits β-secretase 1–mediated insulin receptor cleavage

Autor: Bénédicte, Gaborit, Roland, Govers, Alexandre, Altié, Jean Michel, Brunel, Pierre, Morange, Franck, Peiretti

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistry

International audience; The cleavage of the insulin receptor by β-secretase 1 (BACE1) in the liver increases during diabetes, which contributes to reduce insulin receptor levels and impair insulin signaling. However, the precise signaling events tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d438b123de19467c77e8e9b4739301bb
https://hal.archives-ouvertes.fr/hal-03368302

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Natural substance rutin versus standard drug atorvastatin in a treatment of metabolic syndrome-like condition

Autor: Karol Svik, Ružena Sotníková, Barbara Kaprinay, Lukáš Slovák, Dominika Michalikova, Vladimir Knezl, Boris Lipták, Zdenka Gasparova

Publikováno v: Saudi Pharmaceutical Journal, Vol 27, Iss 8, Pp 1196-1202 (2019)
Saudi Pharmaceutical Journal : SPJ

Background: Metabolic syndrome is a cluster of metabolic risk factors. The clear causes of its development are not known yet and there is no comprehensive treatment of this disease. There is a trend to use natural substances in the treatment of vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0a4581c4c56fe26a14d56f42bc91e9
http://www.sciencedirect.com/science/article/pii/S1319016419301318

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Counter effects of Asiaticosids-D through putative neurotransmission on rotenone induced cerebral ganglionic injury in Lumbricus terrestris

Autor: Arambakkam Janardhanam Vanisree, Mamangam Subaraja

Publikováno v: IBRO Reports, Vol 6, Iss, Pp 160-175 (2019)
IBRO Reports

Highlights • Asiaticoside –D (AD) impact of ganglioside in cerebral ganglions (CGs) of rotenone (ROT)- induced Lumbricus terestris. • Effects of AD on variations of mRNA and protein in CGs of ROT- induced. • AD could maintain the neuroinflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0d602458419f9e5f966c1553e22603
http://www.sciencedirect.com/science/article/pii/S2451830118300967

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Ergothioneine, recent developments

Autor: Barry Halliwell, Irwin K. Cheah

Publikováno v: Redox Biology, Vol 42, Iss, Pp 101868-(2021)
Redox Biology

There has been a recent surge of interest in the unique low molecular weight dietary thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from diet and may play important physiological roles in human health and develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb5988f62bdc6a89d9a45fd4309b814
http://www.sciencedirect.com/science/article/pii/S2213231721000161

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Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions

Autor: Rocco Pizzarelli, Andrea Barberis, Antonino Cattaneo, Enrico Cherubini, Enrica Maria Petrini, Marilena Griguoli, Paola Zacchi

Publikováno v: Neuroscience

To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90608b4dcd3ea52993f032731e6b4192
https://hdl.handle.net/11384/126845

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