Zobrazeno 1 - 10
of 18
pro vyhledávání: '"AChBP – Acetylcholine Binding Protein"'
Autor:
Nikolaos, Alexandris, George, Lagoumintzis, Christos T, Chasapis, Demetres D, Leonidas, Georgios E, Papadopoulos, Socrates J, Tzartos, Aristidis, Tsatsakis, Elias, Eliopoulos, Konstantinos, Poulas, Konstantinos, Farsalinos
Publikováno v:
Toxicology Reports
Graphical abstract
Highlights • SARS-CoV-2 could interact with nAChRs triggering Nicotinic Cholinergic anti-inflammatory system dysregulation. • The α7 nAChRs and SARS-CoV-2 S1 interaction is significantly disturbed by the binding of AChRs
Highlights • SARS-CoV-2 could interact with nAChRs triggering Nicotinic Cholinergic anti-inflammatory system dysregulation. • The α7 nAChRs and SARS-CoV-2 S1 interaction is significantly disturbed by the binding of AChRs
Publikováno v:
Thompson, Andrew J.; Metzger, Simon; Lochner, Martin; Ruepp, Marc-David (2017). The binding orientation of epibatidine at α7 nACh receptors. Neuropharmacology, 116, pp. 421-428. Elsevier 10.1016/j.neuropharm.2017.01.008
Neuropharmacology
Neuropharmacology
Epibatidine is an alkaloid toxin that binds with high affinity to nicotinic and muscarinic acetylcholine receptors, and has been extensively used as a research tool. To examine binding interactions at the nicotinic receptor, it has been co-crystallis
Autor:
Juan Francisco Viso, Fernando Zamarreño, Alejandro Giorgetti, María Julia Amundarain, Marcelo Daniel Costabel
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
γ-aminobutyric acid-type A (GABA A ) receptors mediate fast synaptic inhibition in the central nervous system of mammals. They are modulated via several sites by numerous compounds, which include GABA, benzodiazepines, ethanol, neurosteroids and ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784f249e84350989d9c4f70674e73db4
http://hdl.handle.net/11562/992826
http://hdl.handle.net/11562/992826
Publikováno v:
The Journal of Biological Chemistry
Beta-amyloid (Aβ) has been recognized as an early trigger in the pathogenesis of Alzheimer's disease (AD) leading to synaptic and cognitive impairments. Aβ can alter neuronal signaling through interactions with nicotinic acetylcholine receptors (nA
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 60-73 (2016)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Soil-transmitted helminth infections in humans and livestock cause significant debility, reduced productivity and economic losses globally. There are a limited number of effective anthelmintic drugs available for treating helminths infections, and th
Autor:
Yoshinori Fujiyoshi, Nigel Unwin
Publikováno v:
Journal of Molecular Biology
The nicotinic acetylcholine (ACh) receptor converts transiently to an open-channel form when activated by ACh released into the synaptic cleft. We describe here the conformational change underlying this event, determined by electron microscopy of ACh
Publikováno v:
Neuropharmacology
Crystal structures can identify ligand-receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both 5-HT3 and α
Akademický článek
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Akademický článek
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Publikováno v:
Neuropharmacology
Neuropharmacology; Vol 63
Neuropharmacology; Vol 63
The Erwinia ligand-gated ion channel (ELIC) is a bacterial homologue of vertebrate Cys-loop ligand-gated ion channels. It is activated by GABA, and this property, combined with its structural similarity to GABAA and other Cys-loop receptors, makes it