Zobrazeno 1 - 10
of 40
pro vyhledávání: '"ACY-241"'
Autor:
Mark M. Awad, Yvan Le Bruchec, Brian Lu, Jason Ye, Julie Ann Miller, Patrick H. Lizotte, Megan E. Cavanaugh, Amanda J. Rode, Calin Dan Dumitru, Alexander Spira
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/3963600921ff4ed4ab2f25dbc17d9408
Autor:
Mark M. Awad, Yvan Le Bruchec, Brian Lu, Jason Ye, JulieAnn Miller, Patrick H. Lizotte, Megan E. Cavanaugh, Amanda J. Rode, Calin Dan Dumitru, Alexander Spira
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundHistone deacetylase (HDAC) overexpression has been documented in various cancers and may be associated with worse outcomes. Data from early-phase studies of advanced non-small cell lung cancer (NSCLC) suggest encouraging antitumor activity
Externí odkaz:
https://doaj.org/article/160fc0cc01ca4eaabcc5f6f2e25cfe6a
Autor:
Andressa S. Laino, B. C. Betts, A. Veerapathran, I. Dolgalev, A. Sarnaik, S. N. Quayle, S. S. Jones, J. S. Weber, David M. Woods
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background Therapies targeting anti-tumor T-cell responses have proven successful in the treatment of a variety of malignancies. However, as most patients still fail to respond, approaches to augment immunotherapeutic efficacy are needed. He
Externí odkaz:
https://doaj.org/article/4da9890e824b43518f3c93b6436cf8e7
Akademický článek
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Autor:
Ji Yoon Kim, Seung Yoon Han, Jung Yoo, Go Woon Kim, Yu Hyun Jeon, Sang Wu Lee, Jongsun Park, So Hee Kwon
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8645
HDAC6 is overexpressed in ovarian cancer and is known to be correlated with tumorigenesis. Accordingly, ACY-241, a selective HDAC6 inhibitor, is currently under clinical trial and has been tested in combination with various drugs. HDAC8, another memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0d46846d48ee39b1c58c5af9b00ef2
https://pubmed.ncbi.nlm.nih.gov/35955780
https://pubmed.ncbi.nlm.nih.gov/35955780
Autor:
Megan E. Cavanaugh, Amanda J. Rode, Alexander I. Spira, Yvan Le Bruchec, Jason Ye, JulieAnn Miller, Patrick H. Lizotte, Mark M. Awad, Calin Dan Dumitru, Brian Lu
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology
Frontiers in Oncology
BackgroundHistone deacetylase (HDAC) overexpression has been documented in various cancers and may be associated with worse outcomes. Data from early-phase studies of advanced non-small cell lung cancer (NSCLC) suggest encouraging antitumor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bbb69b8fa18a1072656a43434d8d5d
https://doi.org/10.3389/fonc.2021.696512
https://doi.org/10.3389/fonc.2021.696512
Akademický článek
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Autor:
Jeffrey S. Weber, Andressa S. Laino, A. Veerapathran, Simon S. Jones, David M. Woods, Amod A. Sarnaik, Brian C. Betts, Steven N. Quayle, Igor Dolgalev
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Background Therapies targeting anti-tumor T-cell responses have proven successful in the treatment of a variety of malignancies. However, as most patients still fail to respond, approaches to augment immunotherapeutic efficacy are needed. Here, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6697e12c3fef7b55894861ead557a244
http://link.springer.com/article/10.1186/s40425-019-0517-0
http://link.springer.com/article/10.1186/s40425-019-0517-0
Autor:
Go Woon Kim, So Hee Kwon, So Yeon Kim, Jung Yoo, Ha Young Cho, Sang Wu Lee, Dong-Hoon Lee, Yu Hyun Jeon
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6873, p 6873 (2020)
Volume 21
Issue 18
International Journal of Molecular Sciences, Vol 21, Iss 6873, p 6873 (2020)
Volume 21
Issue 18
Overexpression of histone deacetylase 6 (HDAC6) and bromodomain-containing protein 4 (BRD4) is related to aggressiveness of head and neck squamous carcinoma (HNSCC). Based on studies that HDAC6 and BRD4 are potential therapeutic targets of HNSCC, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83887c273bc34774016655477a42b574
http://europepmc.org/articles/PMC7554925
http://europepmc.org/articles/PMC7554925
Akademický článek
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