Zobrazeno 1 - 10
of 933
pro vyhledávání: '"ACSL4"'
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 579-90 (2024)
The pathogenesis of inflammatory bowel disease (IBD) is closely associated with the dysfunction of the intestinal epithelial barrier, leading to increased bacterial translocation, leukocyte infiltration, and mucosal injury, which may act as a pivotal
Externí odkaz:
https://doaj.org/article/0e2e5119bede407bb085e74ed21833a2
Autor:
Min Wei, Yi Liu, Dongsheng Li, Xingdong Wang, Xiaodong Wang, Yuping Li, Zhengcun Yan, Hengzhu Zhang
Publikováno v:
IBRO Neuroscience Reports, Vol 17, Iss , Pp 161-176 (2024)
Background: Following recent research advancements, an increasing level of evidence had been published to indicate that celastrol exerted a therapeutic effect on a range of nervous system diseases. This study therefore aimed to investigate the potent
Externí odkaz:
https://doaj.org/article/4c2fa24305574465a8cb5bf7506b53c4
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract To analyze the mechanism of how interfering with the cytokeratin 19 (CK19) pathway via the ferroptosis pathway affects tumor biological behaviors in the process of oral squamous cell carcinoma (OSCC) development. TCGA was used to analyze the
Externí odkaz:
https://doaj.org/article/7c39195f1b8c46fea319023fc0c9401a
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Acute pancreatitis (AP) is currently among the most prevalent digestive diseases. The pathogenesis of AP remains elusive, and there is no specific treatment. Therefore, identifying novel therapeutic targets is imperative for effective manage
Externí odkaz:
https://doaj.org/article/892d71d0685e4511b670f9fe6844b43a
Publikováno v:
Journal of Functional Foods, Vol 122, Iss , Pp 106488- (2024)
Current treatments for osteosarcoma, the most common primary bone cancer, including surgery, radiotherapy, and chemotherapy, are largely ineffective against metastatic and chemo-resistant cases, emphasizing the need for novel therapies. In this study
Externí odkaz:
https://doaj.org/article/87475abed2d8438fb7fd2948ab27b67c
Publikováno v:
The Clinical Respiratory Journal, Vol 18, Iss 10, Pp n/a-n/a (2024)
ABSTRACT Introduction As a common malignancy, lung cancer has a relatively poor prognosis and a low survival rate. In recent years, ferroptosis, as an emerging filed, has great promise in the potential treatment of cancer. Brucea javanica oil (BJO) i
Externí odkaz:
https://doaj.org/article/6ca381f332014166944973e496192083
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract The intricate relationship between bile acid (BA) metabolism, M2 macrophage polarization, and hepatitis B virus‐hepatocellular carcinoma (HBV‐HCC) necessitates a thorough investigation of ACSL4's (acyl‐CoA synthetase long‐chain famil
Externí odkaz:
https://doaj.org/article/ef6658c30c0f4e8e84be381c96d5350a
Autor:
Miriam Ceron-Codorniu, Pascual Torres, Anna Fernàndez-Bernal, Santiago Rico-Rios, José CE. Serrano, Maria P. Miralles, Maria Beltran, Ana Garcera, Rosa M. Soler, Reinald Pamplona, Manuel Portero-Otín
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103301- (2024)
The dysfunction of TAR DNA-binding protein 43 (TDP-43) is implicated in various neurodegenerative diseases, though the specific contributions of its toxic gain-of-function versus loss-of-function effects remain unclear. This study investigates the im
Externí odkaz:
https://doaj.org/article/216d6a56aee44db79da4fca5f601d662
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) has recently emerged as a promising therapeutic target in cancer. In this study, we explored the biological function of MAP4K4 in radioresistant breast cancer cells using two M
Externí odkaz:
https://doaj.org/article/1576c2812425494eb616c51d4ceb671b
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