Zobrazeno 1 - 2
of 2
pro vyhledávání: '"ACM, astrocyte conditioned media"'
Autor:
Gerold Schmitt-Ulms, Samih Alqawlaq, Joseph D'Ercole, Anita H. Corbett, Declan Williams, Jeffrey L. Wrana, Alessandro Datti, Darren Chan, Sara W. Leung, Jeremy M Sivak, Alessandra Tuccitto, Izhar Livne-Bar
Publikováno v:
The Journal of Biological Chemistry
Astrocytes can support neuronal survival through a range of secreted signals that protect against neurotoxicity, oxidative stress, and apoptotic cascades. Thus, analyzing the effects of the astrocyte secretome may provide valuable insight into these
Autor:
Luke Jennings, Irina Vázquez Villaseñor, Evangelia Karyka, Paul R. Heath, Heather Mortiboys, Aurelie Schwartzentruber, Paul G. Ince, Julie E. Simpson, Claire J. Garwood, Laura E. Ratcliffe, Stephen B. Wharton
Publikováno v:
Neuroscience
Highlights • We have established a novel human astrocyte-neuron co-culture system. • Astrocytes provided contact-mediated support for neurite outgrowth. • IGF1R-impaired astrocytes are less able to protect neurons under stress conditions. • M